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Am. J. Respir. Crit. Care Med., Volume 164, Number 10, November 2001, S81-S84

Role of Cyclins in Epithelial Response to Oxidants

ANNICK CLEMENT, ALEXANDRA HENRION-CAUDE, VALERIE BESNARD, and SOPHIE CORROYER

Department of Pediatric Pulmonology, INSERM U515, Hôpital Armand Trousseau, Paris, France

Oxidants are involved in a large variety of pulmonary diseases. Among the various cell types that compose the respiratory system, the epithelial cells appear to be a major target for oxidative stress. When cells are exposed to DNA-damaging agents such as oxidants, a feedback control is activated that acts as a brake on the cell cycle to inhibit entry into the S phase until DNA repair is completed. Progression through the G1 phase and the G1-S transition involves sequential assembly and activation of key regulators of the cell cycle machinery, the cyclin-dependent kinases (CDKs). Activity of the CDKs is regulated by several mechanisms, which include the CDK inhibitors (CKIs). The CKI p21CIP1 appears to play an important role in the response of epithelial cells to oxidants.




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Copyright © 2001 American Thoracic Society