help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Online Data Supplement
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PARK, W. Y.
Right arrow Articles by MARTIN, T. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PARK, W. Y.
Right arrow Articles by MARTIN, T. R.

Am. J. Respir. Crit. Care Med., Volume 164, Number 10, November 2001, 1896-1903

Cytokine Balance in the Lungs of Patients with Acute Respiratory Distress Syndrome

WILLIAM Y. PARK, RICHARD B. GOODMAN, KENNETH P. STEINBERG, JOHN T. RUZINSKI, FRANK RADELLA II, DAVID R. PARK, JEROME PUGIN, SHAWN J. SKERRETT, LEONARD D. HUDSON, and THOMAS R. MARTIN

Section of Pulmonary/Critical Care Medicine, Harborview Medical Center, Medical Research Service of the VA Puget Sound Health Care System; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington; and Department of Medical Intensive Care, University of Geneva Medical Center, Geneva, Switzerland

Acute respiratory distress syndrome (ARDS) involves an intense inflammatory response in the lungs, with accumulation of both pro- and antiinflammatory cytokines in bronchoalveolar lavage fluid (BALF). Our goal was to determine how the balance between pro- and antiinflammatory mediators in the lungs changes before and after the onset of ARDS. We identified 23 patients at risk for ARDS and 46 with established ARDS and performed serial bronchoalveolar lavage (BAL). We used immunoassays to measure tumor necrosis factor alpha  (TNF-alpha ) and soluble TNF-alpha receptors I and II; interleukin 1beta (IL-1beta ), IL-1beta receptor antagonist, and soluble IL-1 receptor II; IL-6 and soluble IL-6 receptor; and IL-10. We used sensitive bioassays to measure net TNF-alpha , IL-1beta , and IL-6 activity. Although individual cytokines increased before and after onset of ARDS, greater increases occurred in cognate receptors and/or antagonists, so that molar ratios of agonists/antagonists declined dramatically at the onset of ARDS. The molar ratios remained low for 7 d or longer, limiting the activity of soluble IL-1beta and TNF-alpha in the lungs at the onset of ARDS. This significant antiinflammatory response early in ARDS may provide a key mechanism for limiting the net inflammatory response in the lungs.




This article has been cited by other articles:


Home page
 ChestHome page
A. A. da Cunha, V. Pauli, V. C. Saciura, M. G. S. Pires, L. C. Constantino, B. de Souza, F. Petronilho, J. Rodrigues de Oliveira, C. Ritter, P. R. T. Romao, et al.
N-Methyl-D-Aspartate Glutamate Receptor Blockade Attenuates Lung Injury Associated With Experimental Sepsis
Chest, February 1, 2010; 137(2): 297 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Exp Biol MedHome page
W.-C. Lin, C.-F. Lin, C.-L. Chen, C.-W. Chen, and Y.-S. Lin
Prediction of outcome in patients with acute respiratory distress syndrome by bronchoalveolar lavage inflammatory mediators
Exp Biol Med, January 1, 2010; 235(1): 57 - 65.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
M. Blankstein, R. J. Byrick, M. Nakane, K.W. A. Bang, J. Freedman, R. R. Richards, O. Kajikawa, R. Zdero, D. Bell, and E. H. Schemitsch
Amplified Inflammatory Response to Sequential Hemorrhage, Resuscitation, and Pulmonary Fat Embolism: An Animal Study
J. Bone Joint Surg. Am., January 1, 2010; 92(1): 149 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
U. Matt, J. M. Warszawska, M. Bauer, W. Dietl, I. Mesteri, B. Doninger, I. Haslinger, G. Schabbauer, T. Perkmann, C. J. Binder, et al.
B{beta}15-42 Protects against Acid-induced Acute Lung Injury and Secondary Pseudomonas Pneumonia In Vivo
Am. J. Respir. Crit. Care Med., December 15, 2009; 180(12): 1208 - 1217.
[Abstract] [Full Text] [PDF]

Home page
 Sci Transl MedHome page
M. Cypel, M. Liu, M. Rubacha, J. C. Yeung, S. Hirayama, M. Anraku, M. Sato, J. Medin, B. L. Davidson, M. de Perrot, et al.
Functional Repair of Human Donor Lungs by IL-10 Gene Therapy
Science Translational Medicine, October 28, 2009; 1(4): 4ra9 - 4ra9.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C.-Y. Chen, K.-Y. Yang, M.-Y. Chen, H.-Y. Chen, M.-T. Lin, Y.-C. Lee, R.-P. Perng, S.-L. Hsieh, P.-C. Yang, and T.-Y. Chou
Decoy Receptor 3 Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., October 15, 2009; 180(8): 751 - 760.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Venet, C.-S. Chung, X. Huang, J. Lomas-Neira, Y. Chen, and A. Ayala
Lymphocytes in the Development of Lung Inflammation: A Role for Regulatory CD4+ T Cells in Indirect Pulmonary Lung Injury
J. Immunol., September 1, 2009; 183(5): 3472 - 3480.
[Abstract] [Full Text] [PDF]

Home page
 DMMHome page
J. A. Bastarache and T. S. Blackwell
Development of animal models for the acute respiratory distress syndrome
Dis. Model. Mech., May 1, 2009; 2(5-6): 218 - 223.
[Abstract] [Full Text] [PDF]

Home page
 Exp Biol MedHome page
M. Chopra, J. S. Reuben, and A. C. Sharma
Acute Lung Injury:Apoptosis and Signaling Mechanisms
Exp Biol Med, April 1, 2009; 234(4): 361 - 371.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. R. Pedreira, E. Garcia-Prieto, D. Parra, A. Astudillo, E. Diaz, F. Taboada, and G. M. Albaiceta
Effects of melatonin in an experimental model of ventilator-induced lung injury
Am J Physiol Lung Cell Mol Physiol, November 1, 2008; 295(5): L820 - L827.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. W. Chang, S. Hayashi, S. A. Gharib, T. Vaisar, S. T. King, M. Tsuchiya, J. T. Ruzinski, D. R. Park, G. Matute-Bello, M. M. Wurfel, et al.
Proteomic and Computational Analysis of Bronchoalveolar Proteins during the Course of the Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., October 1, 2008; 178(7): 701 - 709.
[Abstract] [Full Text] [PDF]

Home page
 Exp Biol MedHome page
T. Li, B. Zhao, C. Wang, H. Wang, Z. Liu, W. Li, H. Jin, C. Tang, and J. Du
Regulatory Effects of Hydrogen Sulfide on IL-6, IL-8 and IL-10 Levels in the Plasma and Pulmonary Tissue of Rats with Acute Lung Injury
Exp Biol Med, September 1, 2008; 233(9): 1081 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Matute-Bello, C. W. Frevert, and T. R. Martin
Animal models of acute lung injury
Am J Physiol Lung Cell Mol Physiol, September 1, 2008; 295(3): L379 - L399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
F. Saito, S. Tasaka, K.-i. Inoue, K. Miyamoto, Y. Nakano, Y. Ogawa, W. Yamada, Y. Shiraishi, N. Hasegawa, S. Fujishima, et al.
Role of Interleukin-6 in Bleomycin-Induced Lung Inflammatory Changes in Mice
Am. J. Respir. Cell Mol. Biol., May 1, 2008; 38(5): 566 - 571.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. Kamp, X. Sun, and J. G. N. Garcia
Making Genomics Functional: Deciphering the Genetics of Acute Lung Injury
Proceedings of the ATS, April 15, 2008; 5(3): 348 - 353.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
K. D. Liu and M. A. Matthay
Advances in Critical Care for the Nephrologist: Acute Lung Injury/ARDS
Clin. J. Am. Soc. Nephrol., March 1, 2008; 3(2): 578 - 586.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G D Perkins, F Gao, and D R Thickett
In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury
Thorax, March 1, 2008; 63(3): 215 - 220.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J A Frank, J-F Pittet, C Wray, and M A Matthay
Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade
Thorax, February 1, 2008; 63(2): 147 - 153.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Quesnel, S. Marchand-Adam, A. Fabre, J. Marchal-Somme, I. Philip, S. Lasocki, V. Lecon, B. Crestani, and M. Dehoux
Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury
Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L334 - L343.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. E. White, Q. Ding, B. B. Moore, M. Peters-Golden, L. B. Ware, M. A. Matthay, and M. A. Olman
Prostaglandin E2 Mediates IL-1 -Related Fibroblast Mitogenic Effects in Acute Lung Injury through Differential Utilization of Prostanoid Receptors
J. Immunol., January 1, 2008; 180(1): 637 - 646.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Wu, W. Dong, M. Zhou, F. Zhang, C. P. Marini, T. S. Ravikumar, and P. Wang
Ghrelin Attenuates Sepsis-induced Acute Lung Injury and Mortality in Rats
Am. J. Respir. Crit. Care Med., October 15, 2007; 176(8): 805 - 813.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. Matute-Bello, M. M. Wurfel, J. S. Lee, D. R. Park, C. W. Frevert, D. K. Madtes, S. D. Shapiro, and T. R. Martin
Essential Role of MMP-12 in Fas-Induced Lung Fibrosis
Am. J. Respir. Cell Mol. Biol., August 1, 2007; 37(2): 210 - 221.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. M. Petty, V. Sueblinvong, C. C. Lenox, C. C. Jones, G. P. Cosgrove, C. D. Cool, P. R. Rai, K. K. Brown, D. J. Weiss, M. E. Poynter, et al.
Pulmonary Stromal-Derived Factor-1 Expression and Effect on Neutrophil Recruitment during Acute Lung Injury
J. Immunol., June 15, 2007; 178(12): 8148 - 8157.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. E. McCall and B. K. Yoza
Gene Silencing in Severe Systemic Inflammation
Am. J. Respir. Crit. Care Med., April 15, 2007; 175(8): 763 - 767.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
P. Marik, S. Pastores, D. Annane, R. Speich, C. Schmid, R. Stocker, H. Okamoto, M. J. DiNubile, K. P. Steinberg, L. D. Hudson, et al.
Corticosteroids in ARDS.
N. Engl. J. Med., July 20, 2006; 355(3): 316 - 317.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. M. Schnapp, S. Donohoe, J. Chen, D. A. Sunde, P. M. Kelly, J. Ruzinski, T. Martin, and D. R. Goodlett
Mining the Acute Respiratory Distress Syndrome Proteome: Identification of the Insulin-Like Growth Factor (IGF)/IGF-Binding Protein-3 Pathway in Acute Lung Injury
Am. J. Pathol., July 1, 2006; 169(1): 86 - 95.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
The National Heart, Lung, and Blood Institute Acut
Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome.
N. Engl. J. Med., April 20, 2006; 354(16): 1671 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. N. Gong, B. T. Thompson, P. L. Williams, W. Zhou, M. Z. Wang, L. Pothier, and D. C. Christiani
Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome.
Eur. Respir. J., April 1, 2006; 27(4): 674 - 681.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Q. Xiao, C. G. Freire-de-Lima, W. J. Janssen, K. Morimoto, D. Lyu, D. L. Bratton, and P. M. Henson
Oxidants Selectively Reverse TGF-{beta} Suppression of Proinflammatory Mediator Production
J. Immunol., January 15, 2006; 176(2): 1209 - 1217.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. R. Martin and C. W. Frevert
Innate Immunity in the Lungs
Proceedings of the ATS, December 1, 2005; 2(5): 403 - 411.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. A. Matthay and G. A. Zimmerman
Acute Lung Injury and the Acute Respiratory Distress Syndrome: Four Decades of Inquiry into Pathogenesis and Rational Management
Am. J. Respir. Cell Mol. Biol., October 1, 2005; 33(4): 319 - 327.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. A. Nonas, J. H. Finigan, L. Gao, and J. G. N. Garcia
Functional Genomic Insights into Acute Lung Injury: Role of Ventilators and Mechanical Stress
Proceedings of the ATS, October 1, 2005; 2(3): 188 - 194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S.-F. Ma, D. N. Grigoryev, A. D. Taylor, S. Nonas, S. Sammani, S. Q. Ye, and J. G. N. Garcia
Bioinformatic identification of novel early stress response genes in rodent models of lung injury
Am J Physiol Lung Cell Mol Physiol, September 1, 2005; 289(3): L468 - L477.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. A. Buckley, F. N. Rouhani, M. Kaler, B. Adamik, F. I. Hawari, and S. J. Levine
Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch
Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1132 - L1138.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. L. H. Poelma, B. Lachmann, J. J. Haitsma, L. J. Zimmermann, and J. F. van Iwaarden
Influence of phosphatidylglycerol on the uptake of liposomes by alveolar cells and on lung function
J Appl Physiol, May 1, 2005; 98(5): 1784 - 1791.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. D. Perkins, S. Chatterjee, S. Giles, D. F. McAuley, S. Quinton, D. R. Thickett, and F. Gao
Safety and Tolerability of Nonbronchoscopic Lavage in ARDS
Chest, April 1, 2005; 127(4): 1358 - 1363.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Ashare, L. S. Powers, N. S. Butler, K. C. Doerschug, M. M. Monick, and G. W. Hunninghake
Anti-inflammatory response is associated with mortality and severity of infection in sepsis
Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L633 - L640.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. E. Parsons, M. A. Matthay, L. B. Ware, M. D. Eisner, and and the National Heart, Lung, Blood Institute Acut
Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury
Am J Physiol Lung Cell Mol Physiol, March 1, 2005; 288(3): L426 - L431.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G D Perkins, J Roberts, D F McAuley, L Armstrong, A Millar, F Gao, and D R Thickett
Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury
Thorax, February 1, 2005; 60(2): 153 - 158.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Pugin, S. Stern-Voeffray, B. Daubeuf, M. A. Matthay, G. Elson, and I. Dunn-Siegrist
Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock
Blood, December 15, 2004; 104(13): 4071 - 4079.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al.
Functional Genomics of Lung Disease
Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2/S1): S1 - S81.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Kurahashi, S. Ota, K. Nakamura, Y. Nagashima, T. Yazawa, M. Satoh, A. Fujita, R. Kamiya, E. Fujita, Y. Baba, et al.
Effect of lung-protective ventilation on severe Pseudomonas aeruginosa pneumonia and sepsis in rats
Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L402 - L410.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Nakamura, G. Matute-Bello, W. C. Liles, S. Hayashi, O. Kajikawa, S.-M. Lin, C. W. Frevert, and T. R. Martin
Differential Response of Human Lung Epithelial Cells to Fas-Induced Apoptosis
Am. J. Pathol., June 1, 2004; 164(6): 1949 - 1958.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. D. Sue, J. A. Belperio, M. D. Burdick, L. A. Murray, Y. Y. Xue, M. C. Dy, J. J. Kwon, M. P. Keane, and R. M. Strieter
CXCR2 Is Critical to Hyperoxia-Induced Lung Injury
J. Immunol., March 15, 2004; 172(6): 3860 - 3868.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Olman, K. E. White, L. B. Ware, W. L. Simmons, E. N. Benveniste, S. Zhu, J. Pugin, and M. A. Matthay
Pulmonary Edema Fluid from Patients with Early Lung Injury Stimulates Fibroblast Proliferation through IL-1{beta}-Induced IL-6 Expression
J. Immunol., February 15, 2004; 172(4): 2668 - 2677.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L.-F. Li, L. Yu, and D. A. Quinn
Ventilation-induced Neutrophil Infiltration Depends on c-Jun N-Terminal Kinase
Am. J. Respir. Crit. Care Med., February 15, 2004; 169(4): 518 - 524.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. B. Ware
Modulation of Alveolar Fluid Clearance by Acute Inflammation: The Plot Thickens
Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 332 - 333.
[Full Text] [PDF]

Home page
 Arch DermatolHome page
G. Krueger and K. Callis
Potential of Tumor Necrosis Factor Inhibitors in Psoriasis and Psoriatic Arthritis
Arch Dermatol, February 1, 2004; 140(2): 218 - 225.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
C Nielson and D Wingete
Intensive care and invasive ventilation in the elderly patient, implications of chronic lung disease and comorbidities
Chronic Respiratory Disease, January 1, 2004; 1(1): 43 - 54.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. Lesur, M. Brisebois, A. Thibodeau, F. Chagnon, D. Lane, and T. Fullop
Role of IFN-{gamma} and IL-2 in rat lung epithelial cell migration and apoptosis after oxidant injury
Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L4 - L14.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Kotecha, R J Mildner, L R Prince, J R Vyas, A E Currie, R A Lawson, and M K B Whyte
The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants
Thorax, November 1, 2003; 58(11): 961 - 967.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. P. Mizgerd, M. M. Lupa, M. S. Kogan, H. B. Warren, L. Kobzik, and G. P. Topulos
Nuclear Factor-{kappa}B p50 Limits Inflammation and Prevents Lung Injury during Escherichia coli Pneumonia
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 810 - 817.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. L. Dugernier, P.-F. Laterre, X. Wittebole, J. Roeseler, D. Latinne, M. S. Reynaert, and J. Pugin
Compartmentalization of the Inflammatory Response during Acute Pancreatitis: Correlation with Local and Systemic Complications
Am. J. Respir. Crit. Care Med., July 15, 2003; 168(2): 148 - 157.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. G. Spragg, J. F. Lewis, W. Wurst, D. Hafner, R. P. Baughman, M. D. Wewers, and J. J. Marsh
Treatment of Acute Respiratory Distress Syndrome with Recombinant Surfactant Protein C Surfactant
Am. J. Respir. Crit. Care Med., June 1, 2003; 167(11): 1562 - 1566.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. A. Matthay, G. A. Zimmerman, C. Esmon, J. Bhattacharya, B. Coller, C. M. Doerschuk, J. Floros, M. A. Gimbrone Jr, E. Hoffman, R. D. Hubmayr, et al.
Future Research Directions in Acute Lung Injury: Summary of a National Heart, Lung, and Blood Institute Working Group
Am. J. Respir. Crit. Care Med., April 1, 2003; 167(7): 1027 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Chabot, L. Salez, F. X. McCormack, L. Touqui, and M. Chignard
Surfactant Protein A Inhibits Lipopolysaccharide-Induced In Vivo Production of Interleukin-10 by Mononuclear Phagocytes during Lung Inflammation
Am. J. Respir. Cell Mol. Biol., March 1, 2003; 28(3): 347 - 353.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Hamacher, R. Lucas, H. R. Lijnen, S. Buschke, Y. Dunant, A. Wendel, G. E. Grau, P. M. Suter, and B. Ricou
Tumor Necrosis Factor-{alpha} and Angiostatin Are Mediators of Endothelial Cytotoxicity in Bronchoalveolar Lavages of Patients with Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., September 1, 2002; 166(5): 651 - 656.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Critical Care Medicine in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 565 - 583.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  Red In Translatin