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Am. J. Respir. Crit. Care Med., Volume 164, Number 10, November 2001, 1835-1840

Body Mass Index and Asthma in Adults in Families of Subjects with Asthma in Anqing, China

JUAN C. CELEDÓN, LYLE J. PALMER, AUGUSTO A. LITONJUA, SCOTT T. WEISS, BINYAN WANG, ZHIAN FANG, and XIPING XU

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Program of Population Genetics, Harvard School of Public Health, Boston, Massachusetts; and Anhui Medical Center for Ecogenetics and Disease Control, Anqing, China

We conducted a cross-sectional study of 7,109 adults from families of subjects with asthma in the province of Anhui, China. Asthma was defined either as a combination of physician-diagnosed asthma, airway responsiveness to methacholine at =< 25 mg/ml and two or more respiratory symptoms or asthma attacks ("asthma"); or as a combination of airway responsiveness to methacholine at =< 8 mg/ml and two or more respiratory symptoms or asthma attacks ("symptomatic airway hyperresponsiveness [AHR]"). After adjusting for intensity of cigarette smoking and other variables, both extremes of the body mass index (BMI) distribution were associated with symptomatic AHR in men and women (p < 0.01). In the multivariate analysis, both under- and overweight were associated with asthma in women, and underweight was associated with asthma in men. Among men, those with BMIs of 16 and 30 kg/m2 had 2.5 and 2.3 times higher odds of symptomatic AHR, respectively, than those whose BMI was 21 kg/m2 (95% CI for OR16 vs. 21 kg/m2 = 1.4 to 3.8; 95% CI for OR30 vs. 21 kg/m2 = 1.2 to 5.0). Among women, those with BMIs of 16 and 30 kg/m2 had 2.0 and 2.3 times higher odds of symp- tomatic AHR than those whose BMI was 21 kg/m2 (95% CI for OR16 vs. 21 kg/m2 = 1.3 to 3.1; 95% CI30 vs. 21 kg/m2 = 1.2 to 4.5). Among adults in families of subjects with asthma living in rural China, both underweight and overweight are associated with an increased risk of asthma.




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