help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by RICARD, J.-D.
Right arrow Articles by SAUMON, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by RICARD, J.-D.
Right arrow Articles by SAUMON, G.

Am. J. Respir. Crit. Care Med., Volume 163, Number 5, April 2001, 1176-1180

Production of Inflammatory Cytokines in Ventilator-Induced Lung Injury: A Reappraisal

JEAN-DAMIEN RICARD, DIDIER DREYFUSS, and GEORGES SAUMON

Unité 82, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Xavier Bichat, Paris; and Service de Réanimation Médicale, Hôpital Louis Mourier (Assistance Publique - Hôpitaux de Paris), Colombes, France

We investigated the production of proinflammatory cytokines by the lung during high mechanical stretch in vivo. To do this, we subjected rats to high-volume (42 ml/kg tidal volume [VT]) ventilation for 2 h. The animals developed severe pulmonary edema and alveolar flooding, with a high protein concentration in bronchoalveolar lavage fluid (BALF). The animals' BALF contained no tumor necrosis factor (TNF)-alpha , negligible amounts of interleukin (IL)-1beta , and less than 300 pg/ml of the chemokine macrophage inflammatory protein (MIP)-2, an amount similar to that found in rats ventilated with 7 ml/kg VT. Systemic cytokine levels were below the detection threshold. Because isolated lungs have been shown to produce high levels of proinflammatory cytokines when ventilated with a similarly high VT for the same duration (Tremblay, et al. J Clin Invest 1997;99:944-952), we reconsidered this specific issue. We ventilated isolated, unperfused rat lungs for 2 h with 7 ml/kg or 42 ml/kg VT, or maintained them in a statically inflated state. Negligible amounts of TNF-alpha were found in the BALF whatever the ventilatory condition applied. The BALF IL-1beta concentration was slightly elevated and higher in lungs ventilated with 42 ml/kg VT than in those ventilated with 7 ml/kg VT or in statically inflated lungs (p < 0.05). The BALF MIP-2 concentration was moderately elevated in all isolated lungs (200 to 300 pg/ml), and was slightly higher (p < 0.05) in lungs ventilated with 42 ml/kg VT. After lipopolysaccharide (LPS) challenge, high levels of TNF-alpha , IL-1beta , and MIP-2 were found in the animals' plasma before the lungs were removed. Negligible amounts of TNF-alpha and IL-1beta were retrieved from the BALF of statically inflated lungs. The concentrations of TNF-alpha and IL-1beta were higher in the BALF of ventilated lungs (p < 0.001). The TNF-alpha level did not differ with the magnitude of VT, whereas the level of IL-1beta was significantly higher in BALF of lungs ventilated with 42 ml/kg VT (p < 0.01). The MIP-2 concentrations were similar for the two ventilatory conditions. These results suggest that ventilation that severely injures lungs does not lead to the release of significant amounts of TNF-alpha or IL-1beta by the lung in the absence of LPS challenge but may increase lung MIP-2 production.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
P. Kopterides, T. Kapetanakis, I. I. Siempos, C. Magkou, A. Pelekanou, T. Tsaganos, E. Giamarellos-Bourboulis, C. Roussos, and A. Armaganidis
Short-Term Administration of a High Oxygen Concentration Is Not Injurious in an Ex-Vivo Rabbit Model of Ventilator-Induced Lung Injury
Anesth. Analg., February 1, 2009; 108(2): 556 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Matute-Bello, C. W. Frevert, and T. R. Martin
Animal models of acute lung injury
Am J Physiol Lung Cell Mol Physiol, September 1, 2008; 295(3): L379 - L399.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. M. Otto, K. Markstaller, O. Kajikawa, J. Karmrodt, R. S. Syring, B. Pfeiffer, V. P. Good, C. W. Frevert, and J. E. Baumgardner
Spatial and temporal heterogeneity of ventilator-associated lung injury after surfactant depletion
J Appl Physiol, May 1, 2008; 104(5): 1485 - 1494.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Hara, M. Fujimura, A. Ueda, S. Myou, Y. Oribe, N. Ohkura, T. Kita, M. Yasui, and K. Kasahara
Effect of Pressure Stress Applied to the Airway on Cough-Reflex Sensitivity in Guinea Pigs
Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 585 - 592.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Miyahara, K. Hamanaka, D. S. Weber, M. Anghelescu, J. R. Frost, J. A. King, and J. C. Parker
Cytosolic phospholipase A2 and arachidonic acid metabolites modulate ventilator-induced permeability increases in isolated mouse lungs
J Appl Physiol, February 1, 2008; 104(2): 354 - 362.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Miyahara, K. Hamanaka, D. S. Weber, D. A. Drake, M. Anghelescu, and J. C. Parker
Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L11 - L21.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. R. Wilson, M. E. Goddard, K. P. O'Dea, S. Choudhury, and M. Takata
Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L60 - L68.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J.-S. Jiang, L.-F. Wang, H.-C. Chou, and C.-M. Chen
Angiotensin-converting enzyme inhibitor captopril attenuates ventilator-induced lung injury in rats
J Appl Physiol, June 1, 2007; 102(6): 2098 - 2103.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J.-S. Jerng, Y.-C. Hsu, H.-D. Wu, H.-Z. Pan, H.-C. Wang, C.-T. Shun, C.-J. Yu, and P.-C. Yang
Role of the renin-angiotensin system in ventilator-induced lung injury: an in vivo study in a rat model
Thorax, June 1, 2007; 62(6): 527 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Ota, K. Nakamura, T. Yazawa, Y. Kawaguchi, Y. Baba, R. Kitaoka, N. Morimura, T. Goto, Y. Yamada, and K. Kurahashi
High tidal volume ventilation induces lung injury after hepatic ischemia-reperfusion
Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L625 - L631.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. A. Frank, P. E. Parsons, and M. A. Matthay
Pathogenetic Significance of Biological Markers of Ventilator-Associated Lung Injury in Experimental and Clinical Studies
Chest, December 1, 2006; 130(6): 1906 - 1914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. D. Douillet, W. P. Robinson III, P. M. Milano, R. C. Boucher, and P. B. Rich
Nucleotides induce IL-6 release from human airway epithelia via P2Y2 and p38 MAPK-dependent pathways
Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L734 - L746.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. H. Kim, M. H. Suk, D. W. Yoon, S. H. Lee, G. Y. Hur, K. H. Jung, H. C. Jeong, S. Y. Lee, S. Y. Lee, I. B. Suh, et al.
Inhibition of matrix metalloproteinase-9 prevents neutrophilic inflammation in ventilator-induced lung injury
Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L580 - L587.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. N. Ogawa, A. Ishizaka, S. Tasaka, H. Koh, H. Ueno, F. Amaya, M. Ebina, S. Yamada, Y. Funakoshi, J. Soejima, et al.
Contribution of High-Mobility Group Box-1 to the Development of Ventilator-induced Lung Injury
Am. J. Respir. Crit. Care Med., August 15, 2006; 174(4): 400 - 407.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. G. Hall, Y. Liu, J. M. Hickman-Davis, G. C. Davis, C. Myles, E. J. Andrews, S. Matalon, and J. D. Lang Jr.
Bactericidal Function of Alveolar Macrophages in Mechanically Ventilated Rabbits
Am. J. Respir. Cell Mol. Biol., June 1, 2006; 34(6): 719 - 726.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
G. M. Turino
Therapeutic Gains of Prolonged Bronchial Dilatation in Chronic Obstructive Pulmonary Disease
Ann Intern Med, September 6, 2005; 143(5): 386 - 387.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. D'Angelo, M. Pecchiari, P. D. Valle, A. Koutsoukou, and J. Milic-Emili
Effects of mechanical ventilation at low lung volume on respiratory mechanics and nitric oxide exhalation in normal rabbits
J Appl Physiol, August 1, 2005; 99(2): 433 - 444.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. H. L. C. van Kaam, R. Lutter, R. A. Lachmann, J. J. Haitsma, E. Herting, M. Snoek, A. De Jaegere, J. H. Kok, and B. Lachmann
Effect of ventilation strategy and surfactant on inflammation in experimental pneumonia
Eur. Respir. J., July 1, 2005; 26(1): 112 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K.-J. Bai, A. P. Spicer, M. M. Mascarenhas, L. Yu, C. D. Ochoa, H. G. Garg, and D. A. Quinn
The Role of Hyaluronan Synthase 3 in Ventilator-induced Lung Injury
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 92 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. N. Tremblay and A. S. Slutsky
Pathogenesis of ventilator-induced lung injury: trials and tribulations
Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L596 - L598.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. R. Wilson, S. Choudhury, and M. Takata
Pulmonary inflammation induced by high-stretch ventilation is mediated by tumor necrosis factor signaling in mice
Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L599 - L607.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Yoshikawa, J. A. King, R. N. Lausch, A. M. Penton, F. G. Eyal, and J. C. Parker
Acute ventilator-induced vascular permeability and cytokine responses in isolated and in situ mouse lungs
J Appl Physiol, December 1, 2004; 97(6): 2190 - 2199.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Choudhury, M. R. Wilson, M. E. Goddard, K. P. O'Dea, and M. Takata
Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice
Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L902 - L910.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Dolinay, M. Szilasi, M. Liu, and A. M. K. Choi
Inhaled Carbon Monoxide Confers Antiinflammatory Effects against Ventilator-induced Lung Injury
Am. J. Respir. Crit. Care Med., September 15, 2004; 170(6): 613 - 620.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Kotani, T. Kotani, Z. Li, R. Silbajoris, C.A. Piantadosi, and Y-C.T. Huang
Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch
Eur. Respir. J., August 1, 2004; 24(2): 238 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Kurahashi, S. Ota, K. Nakamura, Y. Nagashima, T. Yazawa, M. Satoh, A. Fujita, R. Kamiya, E. Fujita, Y. Baba, et al.
Effect of lung-protective ventilation on severe Pseudomonas aeruginosa pneumonia and sepsis in rats
Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L402 - L410.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Moriyama, A. Ishizaka, M. Nakamura, H. Kubo, T. Kotani, S. Yamamoto, E. N. Ogawa, O. Kajikawa, C. W. Frevert, Y. Kotake, et al.
Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1114 - L1121.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. B. Copland, F. Martinez, B. P. Kavanagh, D. Engelberts, C. McKerlie, J. Belik, and M. Post
High Tidal Volume Ventilation Causes Different Inflammatory Responses in Newborn versus Adult Lung
Am. J. Respir. Crit. Care Med., March 15, 2004; 169(6): 739 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L.-F. Li, L. Yu, and D. A. Quinn
Ventilation-induced Neutrophil Infiltration Depends on c-Jun N-Terminal Kinase
Am. J. Respir. Crit. Care Med., February 15, 2004; 169(4): 518 - 524.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H.A. Vreugdenhil, C.J. Heijnen, F.B. Plotz, J. Zijlstra, N.J. Jansen, J.J. Haitsma, B. Lachmann, and A.J. van Vught
Mechanical ventilation of healthy rats suppresses peripheral immune function
Eur. Respir. J., January 1, 2004; 23(1): 122 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. M. Steinberg, H. J. Schiller, J. M. Halter, L. A. Gatto, H.-M. Lee, L. A. Pavone, and G. F. Nieman
Alveolar Instability Causes Early Ventilator-induced Lung Injury Independent of Neutrophils
Am. J. Respir. Crit. Care Med., January 1, 2004; 169(1): 57 - 63.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. Adir, P. Factor, V. Dumasius, K. M. Ridge, and J. I. Sznajder
Na,K-ATPase Gene Transfer Increases Liquid Clearance during Ventilation-induced Lung Injury
Am. J. Respir. Crit. Care Med., December 15, 2003; 168(12): 1445 - 1448.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. B. Copland, B. P. Kavanagh, D. Engelberts, C. McKerlie, J. Belik, and M. Post
Early Changes in Lung Gene Expression due to High Tidal Volume
Am. J. Respir. Crit. Care Med., November 1, 2003; 168(9): 1051 - 1059.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Wilson, S. Choudhury, M. E. Goddard, K. P. O'Dea, A. G. Nicholson, and M. Takata
High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury
J Appl Physiol, October 1, 2003; 95(4): 1385 - 1393.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. U. Gurkan, C. O'Donnell, R. Brower, E. Ruckdeschel, and P. M. Becker
Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice
Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L710 - L718.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J-D. Ricard, D. Dreyfuss, and G. Saumon
Ventilator-induced lung injury
Eur. Respir. J., August 1, 2003; 22(42_suppl): 2s - 9s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Dreyfuss, J.-D. Ricard, and G. Saumon
On the Physiologic and Clinical Relevance of Lung-borne Cytokines during Ventilator-induced Lung Injury
Am. J. Respir. Crit. Care Med., June 1, 2003; 167(11): 1467 - 1471.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. C. Bailey, E. L. Martin, L. Zhao, and R. A. W. Veldhuizen
High oxygen concentrations predispose mouse lungsto the deleterious effects of high stretch ventilation
J Appl Physiol, March 1, 2003; 94(3): 975 - 982.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Bhattacharya, N. Sen, M. T. Yiming, R. Patel, K. Parthasarathi, S. Quadri, A. C. Issekutz, and J. Bhattacharya
High Tidal Volume Ventilation Induces Proinflammatory Signaling in Rat Lung Endothelium
Am. J. Respir. Cell Mol. Biol., February 1, 2003; 28(2): 218 - 224.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. M. Waters, P. H. S. Sporn, M. Liu, and J. J. Fredberg
Cellular biomechanics in the lung
Am J Physiol Lung Cell Mol Physiol, September 1, 2002; 283(3): L503 - L509.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. A. Quinn, R. K. Moufarrej, A. Volokhov, and C. A. Hales
Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury
J Appl Physiol, August 1, 2002; 93(2): 517 - 525.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Oudin and J. Pugin
Role of MAP Kinase Activation in Interleukin-8 Production by Human BEAS-2B Bronchial Epithelial Cells Submitted to Cyclic Stretch
Am. J. Respir. Cell Mol. Biol., July 1, 2002; 27(1): 107 - 114.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. J. ROUBY, Q. LU, and I. GOLDSTEIN
Selecting the Right Level of Positive End-Expiratory Pressure in Patients with Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., April 15, 2002; 165(8): 1182 - 1186.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Critical Care Medicine in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 565 - 583.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. BOKER, M. RUTH GRAHAM, K. R. WALLEY, B. M. MCMANUS, L. G. GIRLING, E. WALKER, G. R. LEFEVRE, and W.A. C. MUTCH
Improved Arterial Oxygenation with Biologically Variable or Fractal Ventilation Using Low Tidal Volumes in a Porcine Model of Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., February 15, 2002; 165(4): 456 - 462.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. W. KRAMER, M. IKEGAMI, and A. H. JOBE
Intratracheal Endotoxin Causes Systemic Inflammation in Ventilated Preterm Lambs
Am. J. Respir. Crit. Care Med., February 15, 2002; 165(4): 463 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J.-D. Ricard and D. Dreyfuss
Cytokines During Ventilator-Induced Lung Injury: A Word of Caution
Anesth. Analg., August 1, 2001; 93(2): 251 - 252.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. A. Simon
Message in a Model
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1043 - 1044.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  ATS Coding and Billing Quarterly