help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BRINKMANN, A.
Right arrow Articles by WIEDECK, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BRINKMANN, A.
Right arrow Articles by WIEDECK, H.

Am. J. Respir. Crit. Care Med., Volume 163, Number 5, April 2001, 1150-1152

Does Gastric Juice pH Influence Tonometric PCO2 Measured by Automated Air Tonometry?

ALEXANDER BRINKMANN, BERNHARD GLASBRENNER, ARNIM VLATTEN, HOLGER EBERHARDT, GÖTZ GELDNER, PETER RADERMACHER, MICHAEL GEORGIEFF, and HEIDE WIEDECK

Department of Anesthesiology and Internal Medicine, University Clinics Ulm, Ulm, Germany

To determine the influence of changes in gastric juice pH due to intravenous administration of pentagastrin and omeprazole on intramucosal regional PCO2 (PrCO2), we investigated 17 healthy human volunteers. Gastric juice pH was obtained from a glass pH electrode for continuous gastric juice pH measurement and PrCO2 was measured by using automated air tonometry. After baseline (8:00 A.M.-9:00 A.M.) the subjects received 0.6 µg/kg/h pentagastrin intravenously for 1 h (9:00 A.M.-10:00 A.M., after stimulation 10:00 A.M.-11:00 A.M.) and 40 mg omeprazole intravenously (after omeprazole 11:00 A.M.-3:00 P.M.). Following pentagastrin administration gastric juice pH significantly decreased from 1.2 ± 0.4 to 0.6 ± 0.4 (mean ± SD, p < 0.007, versus baseline), whereas omeprazole transiently increased luminal pH up to 4.4 ± 1.7 (p < 0.007 versus baseline). These subsequent changes in gastric juice pH were accompanied by a significant increase in PrCO2 from 48 ± 12 to 61 ± 17 mm Hg (p < 0.007 versus baseline) and a decrease to 44 ± 5 mm Hg (p < 0.002 versus pentagastrin), respectively. A gastric juice pH > 4 considerably reduces mean gastric PrCO2 and interindividual variability. Thus omeprazole may improve the validity of gastric tonometry data.




This article has been cited by other articles:


Home page
 Biol Res NursHome page
E. M. Fisher, M. E. Kerr, L. A. Hoffman, R. P. Steiner, and R. A. Baranek
A Comparison of Gastric and Rectal CO2 in Cardiac Surgery Patients
Biol Res Nurs, April 1, 2005; 6(4): 268 - 280.
[Abstract] [PDF]

Home page
 Eur J Heart FailHome page
A. Krack, B. M. Richartz, A. Gastmann, K. Greim, U. Lotze, S. D. Anker, and H. R. Figulla
Studies on intragastric PCO2 at rest and during exercise as a marker of intestinal perfusion in patients with chronic heart failure
Eur J Heart Fail, June 1, 2004; 6(4): 403 - 407.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Critical Care Medicine in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 565 - 583.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  New Orleans Int'l Conf