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Am. J. Respir. Crit. Care Med., Volume 163, Number 2, February 2001, 517-523

Mild and Moderate Asthma Is Associated with Airway Goblet Cell Hyperplasia and Abnormalities in Mucin Gene Expression

CLAUDIA L. ORDOÑEZ, RAMIN KHASHAYAR, HOFER H. WONG, RON FERRANDO, REEN WU, DALLAS M. HYDE, JON A. HOTCHKISS, YIFAN ZHANG, ALEXANDER NOVIKOV, GREGORY DOLGANOV, and JOHN V. FAHY

Departments of Pediatrics and Medicine and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California; Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California at Davis, Davis, California; Laboratory for Experimental and Toxicologic Pathology, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan; and Genelabs Technologies, Redwood City, California

Excessive airway mucus is an important cause of morbidity and mortality in asthma, but the relationship between accumulation of mucus and goblet cell size, number, and function is incompletely understood. To address these questions, stored mucin in the epithelium and goblet cell size and number were measured morphometrically, and mucin gene expression was measured by polymerase chain reaction and immunohistochemistry in endobronchial biopsies from 13 subjects with mild and moderate asthma and from 12 healthy control subjects. Secreted mucin was measured in induced sputum. We found that stored mucin in the airway epithelium was three times higher than normal in the subjects with asthma (p < 0.005). Goblet cell size was similar in both groups, but goblet cell number was significantly higher in the subjects with asthma (93,043 ± 15,824 versus 41,959 ± 9,230/mm3, p < 0.05). In mild asthma (FEV1 >=  80% pred, n = 7), the level of stored mucin was as high as in moderate asthma (FEV1 < 80% pred, n = 6), but the level of secreted mucin was significantly lower (28.4 ± 6.3 versus 73.5 ± 47.5 µg/ml, p < 0.05). Secreted mucin was inversely correlated with stored mucin for the whole asthma group (rs = -0.78, p = 0.007). MUC5AC was the predominant mucin gene expressed in healthy subjects and subjects with asthma, and MUC5AC protein was increased in the subjects with asthma. We conclude that even mild asthma is associated with goblet cell hyperplasia and increased stored mucin in the airway epithelium, whereas moderate asthma is associated with increased stored mucin and secreted mucin. These findings suggest that acute degranulation of hyperplastic goblet cells may represent a mechanism for asthma exacerbations in mild and moderate asthma and that chronic degranulation of goblet cells may contribute to chronic airway narrowing in moderate asthma.




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[Abstract] [Full Text] [PDF]

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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Eur. Respir. J., October 1, 2005; 26(4): 577 - 585.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. A. Kuperman, X. Huang, L. Nguyenvu, C. Holscher, F. Brombacher, and D. J. Erle
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J. Immunol., September 15, 2005; 175(6): 3746 - 3752.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
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Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1293 - L1302.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
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Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs
J Appl Physiol, November 1, 2004; 97(5): 1946 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H. Yoshisue, S. M. Puddicombe, S. J. Wilson, H. M. Haitchi, R. M. Powell, D. I. Wilson, A. Pandit, A. E. Berger, D. E. Davies, S. T. Holgate, et al.
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[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
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Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium
Thorax, November 1, 2004; 59(11): 992 - 996.
[Abstract] [Full Text] [PDF]

Home page
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Eur. Respir. J., October 1, 2004; 24(4): 594 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. W. Chu, S. Balzar, G. J. Seedorf, J. Y. Westcott, J. B. Trudeau, P. Silkoff, and S. E. Wenzel
Transforming Growth Factor-{beta}2 Induces Bronchial Epithelial Mucin Expression in Asthma
Am. J. Pathol., October 1, 2004; 165(4): 1097 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
T. Gray, P. Nettesheim, C. Loftin, J.-S. Koo, J. Bonner, S. Peddada, and R. Langenbach
Interleukin-1{beta}-Induced Mucin Production in Human Airway Epithelium Is Mediated by Cyclooxygenase-2, Prostaglandin E2 Receptors, and Cyclic AMP-Protein Kinase A Signaling
Mol. Pharmacol., August 1, 2004; 66(2): 337 - 346.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Hashimoto, B. S. Graham, S. B. Ho, K. B. Adler, R. D. Collins, S. J. Olson, W. Zhou, T. Suzutani, P. W. Jones, K. Goleniewska, et al.
Respiratory Syncytial Virus in Allergic Lung Inflammation Increases Muc5ac and Gob-5
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Up-regulation of MUC5AC and MUC5B Mucin Genes in Chronic Rhinosinusitis
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[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
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Home page
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DNA synthesis and Bcl-2 expression during development of mucous cell metaplasia in airway epithelium of rats exposed to LPS
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[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
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Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1{beta} in human bronchial epithelia
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[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
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Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L847 - L853.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
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Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): S1 - 17.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. E. McParland, P. T. Macklem, and P. D. Pare
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J Appl Physiol, July 1, 2003; 95(1): 426 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
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[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 598 - 618.
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 Am. J. Respir. Crit. Care Med.Home page
J. V. FAHY
Remodeling of the Airway Epithelium in Asthma
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): S46 - 51.
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 J. Immunol.Home page
P.-R. Burgel, S. C. Lazarus, D. C.-W. Tam, I. F. Ueki, K. Atabai, M. Birch, and J. A. Nadel
Human Eosinophils Induce Mucin Production in Airway Epithelial Cells Via Epidermal Growth Factor Receptor Activation
J. Immunol., November 15, 2001; 167(10): 5948 - 5954.
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 Am. J. Respir. Cell Mol. Bio.Home page
M. C. Rose, T. J. Nickola, and J. A. Voynow
Airway Mucus Obstruction: Mucin Glycoproteins, MUC Gene Regulation and Goblet Cell Hyperplasia
Am. J. Respir. Cell Mol. Biol., November 1, 2001; 25(5): 533 - 537.
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 Am. J. Respir. Crit. Care Med.Home page
T. SHIMIZU, H. HIRANO, S. SHIMIZU, C. KISHIOKA, Y. SAKAKURA, and Y. MAJIMA
Differential Properties of Mucous Glycoproteins in Rat Nasal Epithelium . A Comparison between Allergic Inflammation and Lipopolysaccharide Stimulation
Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 1077 - 1082.
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 Genome ResHome page
G. M. Dolganov, P. G. Woodruff, A. A. Novikov, Y. Zhang, R. E. Ferrando, R. Szubin, and J. V. Fahy
A Novel Method of Gene Transcript Profiling in Airway Biopsy Homogenates Reveals Increased Expression of a Na+-K+-Cl- Cotransporter (NKCC1) in Asthmatic Subjects
Genome Res., September 1, 2001; 11(9): 1473 - 1483.
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