help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PARK, J.-H.
Right arrow Articles by MILTON, D. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PARK, J.-H.
Right arrow Articles by MILTON, D. K.

Am. J. Respir. Crit. Care Med., Volume 163, Number 2, February 2001, 322-328

House Dust Endotoxin and Wheeze in the First Year of Life

JU-HYEONG PARK, DIANE R. GOLD, DONNA L. SPIEGELMAN, HARRIET A. BURGE, and DONALD K. MILTON

Department of Environmental Health and Departments of Epidemiology and Biostatistics, Harvard School of Public Health, and The Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts

We examined endotoxin exposure and wheezing episodes during the first year of life in a birth cohort of 499 infants with one or both parents having a history of asthma or allergy. We measured endotoxin in settled dust from the baby's bed, bedroom floor, family room, and kitchen floor within the first 3 mo after birth. The primary outcomes were any wheeze (versus no wheeze), and repeated wheeze (versus one or no report of wheeze). We found a significant univariate association of elevated endotoxin (>=  100 EU/ mg) in family room dust with increased risk of any wheeze (Relative Risk = 1.29, 95% CI = 1.03-1.62). The association was not confounded by cockroach allergen, lower respiratory illness (croup, bronchitis, bronchiolitis, and pneumonia), smoking during pregnancy, lower birth weight, maternal asthma, presence of dog, and race/ethnicity in a multivariate model; the multivariate relative risk (RR = 1.33) was marginally significant (95% CI: 1.00-1.76, p < 0.05). In a multivariate model, controlling for the above covariates, elevated endotoxin in family room dust was significantly associated with increased risk (RR = 1.56, 95% CI = 1.03-2.38) of repeated wheeze. These results suggest that home endotoxin exposure may independently increase risk of any wheeze and repeated wheeze during the first year of life for children with a familial predisposition to asthma or allergy.




This article has been cited by other articles:


Home page
 PediatricsHome page
D. A. Schwartz
Gene-Environment Interactions and Airway Disease in Children
Pediatrics, March 1, 2009; 123(Supplement_3): S151 - S159.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Duan, T. So, and M. Croft
Antagonism of Airway Tolerance by Endotoxin/Lipopolysaccharide through Promoting OX40L and Suppressing Antigen-Specific Foxp3+ T Regulatory Cells
J. Immunol., December 15, 2008; 181(12): 8650 - 8659.
[Abstract] [Full Text] [PDF]

Home page
 CMAJHome page
R. Dales MD MSc(Epi, L. Liu MMD PhD, A. J. Wheeler PhD, and N. L. Gilbert MSc
Quality of indoor residential air and health
Can. Med. Assoc. J., July 15, 2008; 179(2): 147 - 152.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
N. W. J. Schroder and M. Arditi
IEIIS Meeting minireview: The role of innate immunity in the pathogenesis of asthma: evidence for the involvement of Toll-like receptor signaling
Innate Immunity, October 1, 2007; 13(5): 305 - 312.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
Y.-K. Kim, S.-Y. Oh, S. G. Jeon, H.-W. Park, S.-Y. Lee, E.-Y. Chun, B. Bang, H.-S. Lee, M.-H. Oh, Y.-S. Kim, et al.
Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma
J. Immunol., April 15, 2007; 178(8): 5375 - 5382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. A Litonjua, S. L Rifas-Shiman, N. P Ly, K. G Tantisira, J. W Rich-Edwards, C. A Camargo Jr, S. T Weiss, M. W Gillman, and D. R Gold
Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age.
Am. J. Clinical Nutrition, October 1, 2006; 84(4): 903 - 911.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
G. E. Morris, L. C. Parker, J. R. Ward, E. C. Jones, M. K. B. Whyte, C. E. Brightling, P. Bradding, S. K. Dower, and I. Sabroe
Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses
FASEB J, October 1, 2006; 20(12): 2153 - 2155.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. W. Hollingsworth, G. S. Whitehead, K. L. Lin, H. Nakano, M. D. Gunn, D. A. Schwartz, and D. N. Cook
TLR4 Signaling Attenuates Ongoing Allergic Inflammation
J. Immunol., May 15, 2006; 176(10): 5856 - 5862.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. W. Chien, L. P. Zhao, J. A. Hansen, W. H. Fan, T. Parimon, and J. G. Clark
Genetic variation in bactericidal/permeability-increasing protein influences the risk of developing rapid airflow decline after hematopoietic cell transplantation
Blood, March 1, 2006; 107(5): 2200 - 2207.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
D. A. Schwartz, J. H. Freedman, and E. A. Linney
Environmental genomics: a key to understanding biology, pathophysiology and disease
Hum. Mol. Genet., October 1, 2004; 13(suppl_2): R217 - R224.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
S M Kennedy, R Copes, K H Bartlett, and M Brauer
Point-of-sale glass bottle recycling: indoor airborne exposures and symptoms among employees
Occup. Environ. Med., July 1, 2004; 61(7): 628 - 635.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
W. Phipatanakul, J. C. Celedon, B. A. Raby, A. A. Litonjua, D. K. Milton, D. Sredl, S. T. Weiss, and D. R. Gold
Endotoxin Exposure and Eczema in the First Year of Life
Pediatrics, July 1, 2004; 114(1): 13 - 18.
[Abstract] [Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
J.-H. Park, B. Szponar, L. Larsson, D. R. Gold, and D. K. Milton
Characterization of Lipopolysaccharides Present in Settled House Dust
Appl. Envir. Microbiol., January 1, 2004; 70(1): 262 - 267.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Guerra, I. C. Lohman, M. Halonen, F. D. Martinez, and A. L. Wright
Reduced Interferon {gamma} Production and Soluble CD14 Levels in Early Life Predict Recurrent Wheezing by 1 Year of Age
Am. J. Respir. Crit. Care Med., January 1, 2004; 169(1): 70 - 76.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Watanabe, Y. Miyazaki, G. A. Zimmerman, K. H. Albertine, and T. M. McIntyre
Endotoxin Contamination of Ovalbumin Suppresses Murine Immunologic Responses and Development of Airway Hyper-reactivity
J. Biol. Chem., October 24, 2003; 278(43): 42361 - 42368.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
O. Michel
Role of lipopolysaccharide (LPS) in asthma and other pulmonary conditions
Innate Immunity, October 1, 2003; 9(5): 293 - 300.
[Abstract] [PDF]

Home page
 Indoor and Built EnvironmentHome page
R. Rylander and L. Beijer
Microbial Cell Wall Products in Different Fractions of House Dust
Indoor and Built Environment, August 1, 2003; 12(4): 239 - 241.
[Abstract] [PDF]

Home page
 Am J EpidemiolHome page
K. Belanger, W. Beckett, E. Triche, M. B. Bracken, T. Holford, P. Ren, J.-e. McSharry, D. R. Gold, T. A. E. Platts-Mills, and B. P. Leaderer
Symptoms of Wheeze and Persistent Cough in the First Year of Life: Associations with Indoor Allergens, Air Contaminants, and Maternal History of Asthma
Am. J. Epidemiol., August 1, 2003; 158(3): 195 - 202.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Rodriguez, A. C. Keller, E. L. Faquim-Mauro, M. S. de Macedo, F. Q. Cunha, J. Lefort, B. B. Vargaftig, and M. Russo
Bacterial Lipopolysaccharide Signaling Through Toll-Like Receptor 4 Suppresses Asthma-Like Responses Via Nitric Oxide Synthase 2 Activity
J. Immunol., July 15, 2003; 171(2): 1001 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 ANN OCCUP HYGHome page
J. DOUWES, P. THORNE, N. PEARCE, and D. HEEDERIK
Bioaerosol Health Effects and Exposure Assessment: Progress and Prospects
Ann. Hyg., April 1, 2003; 47(3): 187 - 200.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. W. Chu, J. M. Honour, C. A. Rawlinson, R. J. Harbeck, and R. J. Martin
Effects of Respiratory Mycoplasma pneumoniae Infection on Allergen-Induced Bronchial Hyperresponsiveness and Lung Inflammation in Mice
Infect. Immun., March 1, 2003; 71(3): 1520 - 1526.
[Abstract] [Full Text] [PDF]

Home page
 Epidemiol RevHome page
C. Cole Johnson, D. R. Ownby, E. M. Zoratti, S. Hensley Alford, L. K. Williams, and C. L. M. Joseph
Environmental Epidemiology of Pediatric Asthma and Allergy
Epidemiol. Rev., December 1, 2002; 24(2): 154 - 175.
[Full Text] [PDF]

Home page
 Epidemiol RevHome page
M. B. Bracken, K. Belanger, W. O. Cookson, E. Triche, D. C. Christiani, and B. P. Leaderer
Genetic and Perinatal Risk Factors for Asthma Onset and Severity: A Review and Theoretical Analysis
Epidemiol. Rev., December 1, 2002; 24(2): 176 - 189.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. A. Raby, W. T. Klimecki, C. Laprise, Y. Renaud, J. Faith, M. Lemire, C. Greenwood, K. M. Weiland, C. Lange, L. J. Palmer, et al.
Polymorphisms in Toll-Like Receptor 4 Are Not Associated with Asthma or Atopy-related Phenotypes
Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1449 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. G. Moreland, R. M. Fuhrman, J. A. Pruessner, and D. A. Schwartz
CD11b and Intercellular Adhesion Molecule-1 Are Involved in Pulmonary Neutrophil Recruitment in Lipopolysaccharide-Induced Airway Disease
Am. J. Respir. Cell Mol. Biol., October 1, 2002; 27(4): 474 - 480.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
U. Gehring, W. Bischof, B. Fahlbusch, H.-E. Wichmann, and J. Heinrich
House Dust Endotoxin and Allergic Sensitization in Children
Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 939 - 944.
[Abstract] [Full Text]

Home page
 NEJMHome page
C. Braun-Fahrlander, J. Riedler, U. Herz, W. Eder, M. Waser, L. Grize, S. Maisch, D. Carr, F. Gerlach, A. Bufe, et al.
Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children
N. Engl. J. Med., September 19, 2002; 347(12): 869 - 877.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. T. Weiss
Eat Dirt -- The Hygiene Hypothesis and Allergic Diseases
N. Engl. J. Med., September 19, 2002; 347(12): 930 - 931.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Heinrich, G. Bolte, B. Holscher, J. Douwes, I. Lehmann, B. Fahlbusch, W. Bischof, M. Weiss, M. Borte, and H-E. Wichmann
Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates
Eur. Respir. J., September 1, 2002; 20(3): 617 - 623.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. R. Ownby, C. C. Johnson, and E. L. Peterson
Exposure to Dogs and Cats in the First Year of Life and Risk of Allergic Sensitization at 6 to 7 Years of Age
JAMA, August 28, 2002; 288(8): 963 - 972.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
R. Rylander
Review: Endotoxin in the environment -- exposure and effects
Innate Immunity, August 1, 2002; 8(4): 241 - 252.
[Abstract] [PDF]

Home page
 ThoraxHome page
J Douwes, P Gibson, J Pekkanen, and N Pearce
Non-eosinophilic asthma: importance and possible mechanisms
Thorax, July 1, 2002; 57(7): 643 - 648.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Dabbagh, M. E. Dahl, P. Stepick-Biek, and D. B. Lewis
Toll-Like Receptor 4 Is Required for Optimal Development of Th2 Immune Responses: Role of Dendritic Cells
J. Immunol., May 1, 2002; 168(9): 4524 - 4530.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Sabroe, E. C. Jones, L. R. Usher, M. K. B. Whyte, and S. K. Dower
Toll-Like Receptor (TLR)2 and TLR4 in Human Peripheral Blood Granulocytes: A Critical Role for Monocytes in Leukocyte Lipopolysaccharide Responses
J. Immunol., May 1, 2002; 168(9): 4701 - 4710.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 619 - 630.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. J. WRIGHT, S. COHEN, V. CAREY, S. T. WEISS, and D. R. GOLD
Parental Stress as a Predictor of Wheezing in Infancy . A Prospective Birth-Cohort Study
Am. J. Respir. Crit. Care Med., February 1, 2002; 165(3): 358 - 365.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Renz and U. Herz
The bidirectional capacity of bacterial antigens to modulate allergy and asthma
Eur. Respir. J., January 1, 2002; 19(1): 158 - 171.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J Douwes, N Pearce, and D Heederik
Does environmental endotoxin exposure prevent asthma?
Thorax, January 1, 2002; 57(1): 86 - 90.
[Abstract] [Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
D. K. Milton, K. U. Alwis, L. Fisette, and M. Muilenberg
Enzyme-Linked Immunosorbent Assay Specific for (1right-arrow6) Branched, (1right-arrow3)-beta -D-Glucan Detection in Environmental Samples
Appl. Envir. Microbiol., December 1, 2001; 67(12): 5420 - 5424.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. A. Schwartz
Does Inhalation of Endotoxin Cause Asthma?
Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 305 - 306.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  CCM abstracts