Am. J. Respir. Crit. Care Med., Volume 163, Number 1, January 2001, 61-68

Predictors of Loss of Lung Function in the Elderly
The Cardiovascular Health Study

KENT A. GRIFFITH, DUANE L. SHERRILL, ERIN M. SIEGEL, TERI A. MANOLIO, HORACE W. BONEKAT, and PAUL L. ENRIGHT

Respiratory Sciences Center, University of Arizona, Tucson, Arizona; National Heart, Lung, and Blood Institute, Bethesda, Maryland; and University of California at Davis Medical Center, Davis, California

Pulmonary function, as measured by spirometry (FEV₁ or FVC), is an important independent predictor of morbidity and mortality in elderly persons. In this study we examined the predictors of longitudinal decline in lung function for participants of the Cardiovascular Health Study (CHS). The CHS was started in 1990 as a population-based observational study of cardiovascular disease in elderly persons. Spirometry testing was conducted at baseline, 4 and 7 yr later. The data were analyzed using a random effects model (REM) including an AR(1) error structure. There were 5,242 subjects (57.6% female, mean age 73 yr, 87.5% white and 12.5% African-American) with eligible FEV₁ measures representing 89% of the baseline cohort. The REM results showed that African-Americans had significantly lower spirometry levels than whites but that their rate of decline with age was significantly less. Subjects reporting congestive heart failure (CHF), high systolic blood pressure (> 160 mm Hg), or taking beta-blockers had significantly lower spirometry levels; however, the effects of high blood pressure and taking beta-blockers diminished with increasing age. Chronic bronchitis, pneumonia, emphysema, and asthma were associated with reduced spirometry levels. The most notable finding of these analyses was that current smoking (especially for men) was associated with more rapid rates of decline in FVC and FEV₁. African-Americans (especially women) had slower rates of decline in FEV₁ than did whites. Although participants with current asthma had a mean 0.5 L lower FEV₁ at their baseline examination, they did not subsequently experience more rapid declines in FEV₁.

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