help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by TSUCHIYA, M.
Right arrow Articles by INOUE, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TSUCHIYA, M.
Right arrow Articles by INOUE, M.

Am. J. Respir. Crit. Care Med., Volume 163, Number 1, January 2001, 26-31

Propofol versus Midazolam Regarding Their Antioxidant Activities

MASAHIKO TSUCHIYA, AKIRA ASADA, KEIKO MAEDA, YASUYO UEDA, EISUKE F. SATO, MITSUO SHINDO, and MASAYASU INOUE

Department of Biochemistry, and Department of Anesthesiology and Intensive Care Medicine, Osaka City University Medical School, Abenoku, Osaka, Japan

Propofol and midazolam are commonly used as sedatives for critically ill patients. These patients usually suffer from the pathologic effects of oxidative stress, predominantly caused by an imbalance between the generation of reactive oxygen species and the antioxidant defense system. Therefore, the antioxidant activities of propofol and midazolam may be of clinical importance. We investigated the activities of these two sedatives against hydrophilic or lipophilic peroxyl radicals in a homogeneous solution and in the presence of erythrocyte membranes. A chemical analysis of the homogeneous solution revealed that propofol efficiently scavenged hydrophilic peroxyl radicals (50% inhibitory concentration [IC50] = 1.3 × 10-4 M), whereas midazolam efficiently scavenged lipophilic radicals (IC50 = 1.5 × 10-5 M). Further, in membrane systems, propofol inhibited the oxidative damage induced by either hydrophilic or lipophilic radicals (IC50 = 1.5 × 10-5 M for hydrophilic radicals and IC50 = 3.0 × 10-4 M for lipophilic radicals), whereas midazolam did very little. In previous studies, we demonstrated that antioxidant activity is highly affected by the location and properties of the reaction site. The discrepancy in antioxidant activity between a homogeneous condition and in the presence of membranes can be well explained by this concept, and again emphasizes the importance of membranes in determining antioxidant activity. To further understand the biologic significance of these antioxidant properties, the effect of the two agents on endothelium-dependent relaxation was studied. Application of oxidative stress to aortic rings by treating them with peroxyl radicals led to a significant blockade of acetylcholine-induced relaxation after submaximal contraction with phenylephrine. Propofol pretreatment greatly attenuated the impairment in comparison with midazolam, which agrees with the concept of antioxidant activity in the presence of membranes. The results of the present study suggest that propofol has a greater potential to reduce oxidative stress than midazolam.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. Tsuchiya, E. F. Sato, M. Inoue, and A. Asada
Open Abdominal Surgery Increases Intraoperative Oxidative Stress: Can It Be Prevented?
Anesth. Analg., December 1, 2008; 107(6): 1946 - 1952.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K.-C. Chan, C.-J. Lin, P.-H. Lee, C.-F. Chen, Y.-L. Lai, W.-Z. Sun, and Y.-J. Cheng
Propofol Attenuates the Decrease of Dynamic Compliance and Water Content in the Lung by Decreasing Oxidative Radicals Released from the Reperfused Liver
Anesth. Analg., October 1, 2008; 107(4): 1284 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
L. G. Kevin, E. Novalija, and D. F. Stowe
Reactive Oxygen Species as Mediators of Cardiac Injury and Protection: The Relevance to Anesthesia Practice
Anesth. Analg., November 1, 2005; 101(5): 1275 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. E. Marik and J. Varon
The Management of Status Epilepticus
Chest, August 1, 2004; 126(2): 582 - 591.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
R. Alleva, M. Tomasetti, M. D. Solenghi, F. Stagni, F. Gamberini, A. Bassi, P. M. Fornasari, G. Fanelli, and B. Borghi
Lymphocyte DNA damage precedes DNA repair or cell death after orthopaedic surgery under general anaesthesia
Mutagenesis, September 1, 2003; 18(5): 423 - 428.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Critical Care Medicine in AJRCCM 2001
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 565 - 583.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. TSUCHIYA, A. ASADA, E. KASAHARA, E. F. SATO, M. SHINDO, and M. INOUE
Antioxidant Protection of Propofol and Its Recycling in Erythrocyte Membranes
Am. J. Respir. Crit. Care Med., January 1, 2002; 165(1): 54 - 60.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  New Orleans Int'l Conf