help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SHAHAR, E.
Right arrow Articles by SAMET, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SHAHAR, E.
Right arrow Articles by SAMET, J. M.

Am. J. Respir. Crit. Care Med., Volume 163, Number 1, January 2001, 19-25

Sleep-disordered Breathing and Cardiovascular Disease
Cross-sectional Results of the Sleep Heart Health Study

EYAL SHAHAR, CORALYN W. WHITNEY, SUSAN REDLINE, ELISA T. LEE, ANNE B. NEWMAN, F. JAVIER NIETO, GEORGE T. O'CONNOR, LORI L. BOLAND, JOSEPH E. SCHWARTZ, and JONATHAN M. SAMET, for the Sleep Heart Health Study Research Group

Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota; Department of Biostatistics, University of Washington, Seattle, Washington; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio; Center for American Indian Health Research, University of Oklahoma, Oklahoma City, Oklahoma; Division of Geriatric Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts; and Department of Psychiatry, State University of New York, Stony Brook, New York

Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-living individuals who underwent overnight, unattended polysomnography at home. Sleep-disordered breathing was quantified by the apnea-hypopnea index (AHI)---the average number of apneas and hypopneas per hour of sleep. Mild to moderate disordered breathing during sleep was highly prevalent in the sample (median AHI: 4.4; interquartile range: 1.3 to 11.0). A total of 1,023 participants (16%) reported at least one manifestation of CVD (myocardial infarction, angina, coronary revascularization procedure, heart failure, or stroke). The multivariable-adjusted relative odds (95% CI) of prevalent CVD for the second, third, and fourth quartiles of the AHI (versus the first) were 0.98 (0.77-1.24), 1.28 (1.02-1.61), and 1.42 (1.13-1.78), respectively. Sleep-disordered breathing was associated more strongly with self-reported heart failure and stroke than with self-reported coronary heart disease: the relative odds (95% CI) of heart failure, stroke, and coronary heart disease (upper versus lower AHI quartile) were 2.38 (1.22-4.62), 1.58 (1.02- 2.46), and 1.27 (0.99-1.62), respectively. These findings are compatible with modest to moderate effects of sleep-disordered breathing on heterogeneous manifestations of CVD within a range of AHI values that are considered normal or only mildly elevated.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. Arens and H. Muzumdar
Childhood obesity and obstructive sleep apnea syndrome
J Appl Physiol, February 1, 2010; 108(2): 436 - 444.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Attal and P. Chanson
Endocrine Aspects of Obstructive Sleep Apnea
J. Clin. Endocrinol. Metab., February 1, 2010; 95(2): 483 - 495.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. A. Dempsey, S. C. Veasey, B. J. Morgan, and C. P. O'Donnell
Pathophysiology of Sleep Apnea
Physiol Rev, January 1, 2010; 90(1): 47 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M-C. L. Machado, W. M. Vollmer, S. M. Togeiro, A. L. Bilderback, M-V. C. Oliveira, F. S. Leitao, F. Queiroga Jr, G. Lorenzi-Filho, and J. A. Krishnan
CPAP and survival in moderate-to-severe obstructive sleep apnoea syndrome and hypoxaemic COPD
Eur. Respir. J., January 1, 2010; 35(1): 132 - 137.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. E. Dyken and K. B. Im
Obstructive Sleep Apnea and Stroke
Chest, December 1, 2009; 136(6): 1668 - 1677.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Kizawa, Y. Nakamura, S. Takahashi, S. Sakurai, K. Yamauchi, and H. Inoue
Pathogenic role of angiotensin II and oxidised LDL in obstructive sleep apnoea
Eur. Respir. J., December 1, 2009; 34(6): 1390 - 1398.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
S Ryan, C T Taylor, and W T McNicholas
Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?
Postgrad. Med. J., December 1, 2009; 85(1010): 693 - 698.
[Abstract] [Full Text] [PDF]

Home page
 Vasc MedHome page
H. A Chami, M. J Keyes, J. A Vita, G. F Mitchell, M. G Larson, S. Fan, R. S Vasan, G. T O'Connor, E. J Benjamin, and D. J Gottlieb
Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing
Vascular Medicine, November 1, 2009; 14(4): 351 - 360.
[Abstract] [PDF]

Home page
 Cleveland Clinic Journal of MedicineHome page
S. SHAFAZAND
Perioperative management of obstructive sleep apnea: Ready for prime time?
Cleveland Clinic Journal of Medicine, November 1, 2009; 76(Suppl_4): S98 - S103.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
G. D. Foster, K. E. Borradaile, M. H. Sanders, R. Millman, G. Zammit, A. B. Newman, T. A. Wadden, D. Kelley, R. R. Wing, F. X. Pi-Sunyer, et al.
A Randomized Study on the Effect of Weight Loss on Obstructive Sleep Apnea Among Obese Patients With Type 2 Diabetes: The Sleep AHEAD Study
Arch Intern Med, September 28, 2009; 169(17): 1619 - 1626.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
N. Haruki, M. Takeuchi, H. Nakai, Y. Kanazawa, N. Tsubota, R. Shintome, R. M. Lang, and Y. Otsuji
Overnight sleeping induced daily repetitive left ventricular systolic and diastolic dysfunction in obstructive sleep apnoea: quantitative assessment using tissue Doppler imaging
Eur J Echocardiogr, August 1, 2009; 10(6): 769 - 775.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
Y. W. Endeshaw, M. L. Unruh, M. Kutner, A. B. Newman, and D. L. Bliwise
Sleep-disordered Breathing and Frailty in the Cardiovascular Health Study Cohort
Am. J. Epidemiol., July 15, 2009; 170(2): 193 - 202.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Ryan, C T Taylor, and W T McNicholas
Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?
Thorax, July 1, 2009; 64(7): 631 - 636.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. A. Martinez-Garcia, J. J. Soler-Cataluna, L. Ejarque-Martinez, Y. Soriano, P. Roman-Sanchez, F. B. Illa, J. M. M. Canal, and J. Duran-Cantolla
Continuous Positive Airway Pressure Treatment Reduces Mortality in Patients with Ischemic Stroke and Obstructive Sleep Apnea: A 5-Year Follow-up Study
Am. J. Respir. Crit. Care Med., July 1, 2009; 180(1): 36 - 41.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A Alonso-Fernandez, F Garcia-Rio, M A Arias, A Hernanz, M de la Pena, J Pierola, A Barcelo, E Lopez-Collazo, and A Agusti
Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial
Thorax, July 1, 2009; 64(7): 581 - 586.
[Abstract] [Full Text] [PDF]

Home page
 AMERICAN JOURNAL OF LIFESTYLE MEDICINEHome page
S. F. Quan
Sleep Disturbances and Their Relationship to Cardiovascular Disease
American Journal of Lifestyle Medicine, July 1, 2009; 3(1_suppl): 55S - 59S.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
G. E. Foster, J. V. Brugniaux, V. Pialoux, C. T. C. Duggan, P. J. Hanly, S. B. Ahmed, and M. J. Poulin
Cardiovascular and cerebrovascular responses to acute hypoxia following exposure to intermittent hypoxia in healthy humans
J. Physiol., July 1, 2009; 587(13): 3287 - 3299.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
R. Mehra, K. L. Stone, P. D. Varosy, A. R. Hoffman, G. M. Marcus, T. Blackwell, O. A. Ibrahim, R. Salem, and S. Redline
Nocturnal Arrhythmias Across a Spectrum of Obstructive and Central Sleep-Disordered Breathing in Older Men: Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study
Arch Intern Med, June 22, 2009; 169(12): 1147 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
T. Bitter, L. Faber, D. Hering, C. Langer, D. Horstkotte, and O. Oldenburg
Sleep-disordered breathing in heart failure with normal left ventricular ejection fraction
Eur J Heart Fail, June 1, 2009; 11(6): 602 - 608.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C.-H. Lee, S.-M. Khoo, B.-C. Tai, E. Y. Chong, C. Lau, Y. Than, D.-X. Shi, L.-C. Lee, A. Kailasam, A. F. Low, et al.
Obstructive Sleep Apnea in Patients Admitted for Acute Myocardial Infarction: Prevalence, Predictors, and Effect on Microvascular Perfusion
Chest, June 1, 2009; 135(6): 1488 - 1495.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. E. Nisbet, A. S. Graves, D. J. Kleinhenz, H. L. Rupnow, A. L. Reed, T.-H. M. Fan, P. O. Mitchell, R. L. Sutliff, and C. M. Hart
The Role of NADPH Oxidase in Chronic Intermittent Hypoxia-Induced Pulmonary Hypertension in Mice
Am. J. Respir. Cell Mol. Biol., May 1, 2009; 40(5): 601 - 609.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y.- J. Peng, J. Nanduri, G. Yuan, N. Wang, E. Deneris, S. Pendyala, V. Natarajan, G. K. Kumar, and N. R. Prabhakar
NADPH Oxidase Is Required for the Sensory Plasticity of the Carotid Body by Chronic Intermittent Hypoxia
J. Neurosci., April 15, 2009; 29(15): 4903 - 4910.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. A. Hunt, W. T. Abraham, M. H. Chin, A. M. Feldman, G. S. Francis, T. G. Ganiats, M. Jessup, M. A. Konstam, D. M. Mancini, K. Michl, et al.
2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation
J. Am. Coll. Cardiol., April 14, 2009; 53(15): e1 - e90.
[Full Text] [PDF]

Home page
 CirculationHome page
2005 WRITING COMMITTEE MEMBERS, S. A. Hunt, W. T. Abraham, M. H. Chin, A. M. Feldman, G. S. Francis, T. G. Ganiats, M. Jessup, M. A. Konstam, D. M. Mancini, et al.
2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the International Society for Heart and Lung Transplantation
Circulation, April 14, 2009; 119(14): e391 - e479.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Roche, J-M. Gaspoz, V. Pichot, M. Picard-Kossovsky, D. Maudoux, A. Garcin, S. Celle, E. Sforza, J. C. Barthelemy, and on behalf of the PROOF and SYNAPSE Study Groups
Association between C-reactive protein and unrecognised sleep-disordered breathing in the elderly
Eur. Respir. J., April 1, 2009; 33(4): 797 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. L. Riha, T. Gislasson, and K. Diefenbach
The phenotype and genotype of adult obstructive sleep apnoea/hypopnoea syndrome
Eur. Respir. J., March 1, 2009; 33(3): 646 - 655.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. Champagne, K. Schwartzman, L. Opatrny, P. Barriga, L. Morin, A. Mallozzi, A. Benjamin, and R. J. Kimoff
Obstructive sleep apnoea and its association with gestational hypertension
Eur. Respir. J., March 1, 2009; 33(3): 559 - 565.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. J. Sim, S. A. Rasgon, D. A. Kujubu, V. A. Kumar, I. L. A. Liu, J. M. Shi, T. T. Pham, and S. F. Derose
Sleep Apnea in Early and Advanced Chronic Kidney Disease: Kaiser Permanente Southern California Cohort
Chest, March 1, 2009; 135(3): 710 - 716.
[Abstract] [Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
Y. W. Endeshaw, W. B. White, M. Kutner, J. G. Ouslander, and D. L. Bliwise
Sleep-Disordered Breathing and 24-Hour Blood Pressure Pattern Among Older Adults
J Gerontol A Biol Sci Med Sci, February 5, 2009; (2009) gln011v1.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
V. Savransky, C. Reinke, J. Jun, S. Bevans-Fonti, A. Nanayakkara, J. Li, A. C. Myers, M. S. Torbenson, and V. Y. Polotsky
Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in mice
Exp Physiol, February 1, 2009; 94(2): 228 - 239.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Nanduri, N. Wang, G. Yuan, S. A. Khan, D. Souvannakitti, Y.-J. Peng, G. K. Kumar, J. A. Garcia, and N. R. Prabhakar
Intermittent hypoxia degrades HIF-2{alpha} via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities
PNAS, January 27, 2009; 106(4): 1199 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Kenchaiah, H. D. Sesso, and J. M. Gaziano
Body Mass Index and Vigorous Physical Activity and the Risk of Heart Failure Among Men
Circulation, January 6, 2009; 119(1): 44 - 52.
[Abstract] [Full Text] [PDF]

Home page
 ACCP Sleep Med Brd RevHome page
H. K. Yaggi
Sleep and the Cardiovascular System
ACCP Sleep Med Brd Rev, January 1, 2009; 4(0): 123 - 132.
[Full Text] [PDF]

Home page
 ACCP Sleep Med Brd RevHome page
A. Malhotra
Obstructive Sleep Apnea and Central Sleep Apnea: Epidemiology, Pathophysiology, and Risk Factors
ACCP Sleep Med Brd Rev, January 1, 2009; 4(0): 193 - 200.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
U. Kuhlmann, F. G. Bormann, and H. F. Becker
Obstructive sleep apnoea: clinical signs, diagnosis and treatment
Nephrol. Dial. Transplant., January 1, 2009; 24(1): 8 - 14.
[Full Text] [PDF]

Home page
 EuropaceHome page
B. Sredniawa, R. Lenarczyk, O. Kowalski, P. Pruszkowska-Skrzep, J. Kowalczyk, A. Musialik-Lydka, S. Cebula, and Z. Kalarus
Sleep apnoea as a predictor of mid- and long-term outcome in patients undergoing cardiac resynchronization therapy
Europace, January 1, 2009; 11(1): 106 - 114.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. S. Floras
Hypertension, Sleep Apnea, and Atherosclerosis
Hypertension, January 1, 2009; 53(1): 1 - 3.
[Full Text] [PDF]

Home page
 HypertensionHome page
L. F. Drager, L. A. Bortolotto, E. M. Krieger, and G. Lorenzi-Filho
Additive Effects of Obstructive Sleep Apnea and Hypertension on Early Markers of Carotid Atherosclerosis
Hypertension, January 1, 2009; 53(1): 64 - 69.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Urbano, F. Roux, J. Schindler, and V. Mohsenin
Impaired cerebral autoregulation in obstructive sleep apnea
J Appl Physiol, December 1, 2008; 105(6): 1852 - 1857.
[Abstract] [Full Text] [PDF]

Home page
 NDT PlusHome page
T. Masuda, M. Murata, S. Honma, Y. Iwazu, M. Ogura, A. Onishi, K. Shimada, E. Kusano, and Y. Asano
Nocturnal hypoxia is associated with elevated C-reactive protein in dialysis patients
NDT Plus, December 1, 2008; 1(6): 470 - 471.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
V. Savransky, J. Jun, J. Li, A. Nanayakkara, S. Fonti, A. B. Moser, K. E. Steele, M. A. Schweitzer, S. P. Patil, S. Bhanot, et al.
Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase
Circ. Res., November 7, 2008; 103(10): 1173 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Kobayashi, N. Miyazawa, M. Takeno, S. Murakami, Y. Kirino, A. Okouchi, T. Kaneko, and Y. Ishigatsubo
Circulating Carbon Monoxide Level Is Elevated After Sleep in Patients With Obstructive Sleep Apnea
Chest, November 1, 2008; 134(5): 904 - 910.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Liu, L. Pichard, H. Schneider, S. P. Patil, P. L. Smith, V. Polotsky, and A. R. Schwartz
Neuromechanical control of the isolated upper airway of mice
J Appl Physiol, October 1, 2008; 105(4): 1237 - 1245.
[Abstract] [Full Text] [PDF]

Home page
 NDT PlusHome page
T. Masuda, M. Murata, S. Honma, Y. Iwazu, M. Ogura, A. Onishi, K. Shimada, E. Kusano, and Y. Asano
Pulse oximetry is useful for screening sleep apnoea syndrome in dialysis patients
NDT Plus, October 1, 2008; 1(5): 378 - 379.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. Moss
Clinical Year in Review I: Lung Cancer, Pleural Disease, Exercise Testing and Pulmonary Rehabilitation, and Sleep Medicine
Proceedings of the ATS, September 15, 2008; 5(7): 739 - 744.
[Full Text] [PDF]

Home page
 CirculationHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
Circulation, September 2, 2008; 118(10): 1080 - 1111.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
F. Chung, B. Yegneswaran, F. Herrera, A. Shenderey, and C. M. Shapiro
Patients with Difficult Intubation May Need Referral to Sleep Clinics
Anesth. Analg., September 1, 2008; 107(3): 915 - 920.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A M Li, C T Au, R Y T Sung, C Ho, P C Ng, T F Fok, and Y K Wing
Ambulatory blood pressure in children with obstructive sleep apnoea: a community based study
Thorax, September 1, 2008; 63(9): 803 - 809.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
F. Valham, T. Mooe, T. Rabben, H. Stenlund, U. Wiklund, and K. A. Franklin
Increased Risk of Stroke in Patients With Coronary Artery Disease and Sleep Apnea: A 10-Year Follow-Up
Circulation, August 26, 2008; 118(9): 955 - 960.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
J. Am. Coll. Cardiol., August 19, 2008; 52(8): 686 - 717.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
A. R. Schwartz, S. P. Patil, H. Schneider, and P. L. Smith
Modelling pathogenic mechanisms of upper airway dysfunction in the molecular age
Eur. Respir. J., August 1, 2008; 32(2): 255 - 258.
[Full Text] [PDF]

Home page
 CirculationHome page
H. A. Chami, R. B. Devereux, J. S. Gottdiener, R. Mehra, M. J. Roman, E. J. Benjamin, and D. J. Gottlieb
Left Ventricular Morphology and Systolic Function in Sleep-Disordered Breathing: The Sleep Heart Health Study
Circulation, May 20, 2008; 117(20): 2599 - 2607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. M. Punjabi, A. B. Newman, T. B. Young, H. E. Resnick, and M. H. Sanders
Sleep-disordered Breathing and Cardiovascular Disease: An Outcome-based Definition of Hypopneas
Am. J. Respir. Crit. Care Med., May 15, 2008; 177(10): 1150 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. D. Schocken, E. J. Benjamin, G. C. Fonarow, H. M. Krumholz, D. Levy, G. A. Mensah, J. Narula, E. S. Shor, J. B. Young, and Y. Hong
Prevention of Heart Failure: A Scientific Statement From the American Heart Association Councils on Epidemiology and Prevention, Clinical Cardiology, Cardiovascular Nursing, and High Blood Pressure Research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group
Circulation, May 13, 2008; 117(19): 2544 - 2565.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Pawar, Y.-J. Peng, F. J. Jacono, and N. R. Prabhakar
Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia
J Appl Physiol, May 1, 2008; 104(5): 1287 - 1294.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. Hwang, N. Shakir, B. Limann, C. Sison, S. Kalra, L. Shulman, A. d. C. Souza, and H. Greenberg
Association of Sleep-Disordered Breathing With Postoperative Complications
Chest, May 1, 2008; 133(5): 1128 - 1134.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. Kiekens, Veva De Groot, T. Coeckelbergh, M.-J. Tassignon, P. van de Heyning, Wilfried De Backer, and J. Verbraecken
Continuous Positive Airway Pressure Therapy Is Associated with an Increase in Intraocular Pressure in Obstructive Sleep Apnea
Invest. Ophthalmol. Vis. Sci., March 1, 2008; 49(3): 934 - 940.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. Lopez-Jimenez, F. H. Sert Kuniyoshi, A. Gami, and V. K. Somers
Obstructive Sleep Apnea: Implications for Cardiac and Vascular Disease
Chest, March 1, 2008; 133(3): 793 - 804.
[Full Text] [PDF]

Home page
 ChestHome page
T. Kasai, K. Narui, T. Dohi, N. Yanagisawa, S. Ishiwata, M. Ohno, T. Yamaguchi, and S.-i. Momomura
Prognosis of Patients With Heart Failure and Obstructive Sleep Apnea Treated With Continuous Positive Airway Pressure
Chest, March 1, 2008; 133(3): 690 - 696.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Reuveni, S. Greenberg-Dotan, T. Simon-Tuval, A. Oksenberg, and A. Tarasiuk
Elevated healthcare utilisation in young adult males with obstructive sleep apnoea
Eur. Respir. J., February 1, 2008; 31(2): 273 - 279.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
J Amit Benjamin and K E Lewis
Sleep-disordered breathing and cardiovascular disease
Postgrad. Med. J., January 1, 2008; 84(987): 15 - 22.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. K. Han, V. V. McLaughlin, G. J. Criner, and F. J. Martinez
Pulmonary Diseases and the Heart
Circulation, December 18, 2007; 116(25): 2992 - 3005.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. J. Buchner, B. M. Sanner, J. Borgel, and L. C. Rump
Continuous Positive Airway Pressure Treatment of Mild to Moderate Obstructive Sleep Apnea Reduces Cardiovascular Risk
Am. J. Respir. Crit. Care Med., December 15, 2007; 176(12): 1274 - 1280.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
B. Buyse, J. Hedner, and the participants of working group 2
Sleep apnoea, hypertension and vascular disease: where are we now?
Eur. Respir. Rev., December 1, 2007; 16(106): 169 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Exp Biol MedHome page
C. Selmi, N. Montano, R. Furlan, C. L. Keen, and M. E. Gershwin
Inflammation and Oxidative Stress in Obstructive Sleep Apnea Syndrome
Exp Biol Med, December 1, 2007; 232(11): 1409 - 1413.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Romero-Corral, V. K. Somers, P. A. Pellikka, E. J. Olson, K. R. Bailey, J. Korinek, M. Orban, J. Sierra-Johnson, M. Kato, R. S. Amin, et al.
Decreased Right and Left Ventricular Myocardial Performance in Obstructive Sleep Apnea
Chest, December 1, 2007; 132(6): 1863 - 1870.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. R. Benbadis and L. Liu
CPAP: A treatment for epilepsy?
Neurology, November 6, 2007; 69(19): 1814 - 1815.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Howitt, K. Kairaitis, J. P. Kirkness, S. R. Garlick, J. R. Wheatley, K. Byth, and T. C. Amis
Oscillatory pressure wave transmission from the upper airway to the carotid artery
J Appl Physiol, November 1, 2007; 103(5): 1622 - 1627.
[Abstract] [Full Text] [PDF]

Home page
 Br J OphthalmolHome page
J. Li, G. McGwin Jr, M. S Vaphiades, and C. Owsley
Non-arteritic anterior ischaemic optic neuropathy and presumed sleep apnoea syndrome screened by the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ)
Br J Ophthalmol, November 1, 2007; 91(11): 1524 - 1527.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Yumino and T. D. Bradley
Pathogenesis of Atherosclerosis: Is Obstructive Sleep Apnea the New Kid on the Block?
Am. J. Respir. Crit. Care Med., October 1, 2007; 176(7): 634 - 635.
[Full Text] [PDF]

Home page
 ChestHome page
N. M. Punjabi, B. A. Beamer, A. Jain, M. E. Spencer, and N. Fedarko
Elevated Levels of Neopterin in Sleep-Disordered Breathing
Chest, October 1, 2007; 132(4): 1124 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
Authors/Task Force Members, P. E. Vardas, A. Auricchio, J.-J. Blanc, J.-C. Daubert, H. Drexler, H. Ector, M. Gasparini, C. Linde, F. B. Morgado, et al.
Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in Collaboration with the European Heart Rhythm Association
Europace, October 1, 2007; 9(10): 959 - 998.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. T. McNicholas
Cardiovascular outcomes of CPAP therapy in obstructive sleep apnea syndrome
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1666 - R1670.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Parati, C. Lombardi, and K. Narkiewicz
Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1671 - R1683.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Authors/Task Force Members, P. E. Vardas, A. Auricchio, J.-J. Blanc, J.-C. Daubert, H. Drexler, H. Ector, M. Gasparini, C. Linde, F. B. Morgado, et al.
Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in Collaboration with the European Heart Rhythm Association
Eur. Heart J., September 2, 2007; 28(18): 2256 - 2295.
[Full Text] [PDF]

Home page
 ChestHome page
P. Steiropoulos, V. Tsara, E. Nena, C. Fitili, M. Kataropoulou, M. Froudarakis, P. Christaki, and D. Bouros
Effect of Continuous Positive Airway Pressure Treatment on Serum Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea-Hypopnea Syndrome
Chest, September 1, 2007; 132(3): 843 - 851.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
Y.-L. Lo, A. S Jordan, A. Malhotra, A. Wellman, R. A Heinzer, M. Eikermann, K. Schory, L. Dover, and D. P White
Influence of wakefulness on pharyngeal airway muscle activity
Thorax, September 1, 2007; 62(9): 799 - 805.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Redline, A. Storfer-Isser, C. L. Rosen, N. L. Johnson, H. L. Kirchner, J. Emancipator, and A. M. Kibler
Association between Metabolic Syndrome and Sleep-disordered Breathing in Adolescents
Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 401 - 408.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. B. Bucca, L. Brussino, A. Battisti, R. Mutani, G. Rolla, L. Mangiardi, and A. Cicolin
Diuretics in Obstructive Sleep Apnea With Diastolic Heart Failure
Chest, August 1, 2007; 132(2): 440 - 446.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. L. Stanchina, K. Ellison, A. Malhotra, M. Anderson, M. Kirk, M. E. Benser, C. Tosi, C. Carlisle, R. P. Millman, and A. Buxton
The Impact of Cardiac Resynchronization Therapy on Obstructive Sleep Apnea in Heart Failure Patients: A Pilot Study
Chest, August 1, 2007; 132(2): 433 - 439.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. P. Patil, H. Schneider, A. R. Schwartz, and P. L. Smith
Adult Obstructive Sleep Apnea: Pathophysiology and Diagnosis
Chest, July 1, 2007; 132(1): 325 - 337.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Lorenzi-Filho and L. F. Drager
Obstructive Sleep Apnea and Atherosclerosis: A New Paradigm
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1219 - 1221.
[Full Text] [PDF]

Home page
 ThoraxHome page
S. Ryan, G. M Nolan, E. Hannigan, S. Cunningham, C. Taylor, and W. T McNicholas
Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity
Thorax, June 1, 2007; 62(6): 509 - 514.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
L. A. Smith, M. Vennelle, R. S. Gardner, T. A. McDonagh, M. A. Denvir, N. J. Douglas, and D. E. Newby
Auto-titrating continuous positive airway pressure therapy in patients with chronic heart failure and obstructive sleep apnoea: a randomized placebo-controlled trial
Eur. Heart J., May 2, 2007; 28(10): 1221 - 1227.
[Abstract] [Full Text] [PDF]

Home page
 The Diabetes EducatorHome page
E. R. Chasens
Understanding Sleep in Persons With Diabetes
The Diabetes Educator, May 1, 2007; 33(3): 435 - 441.
[Abstract] [Full Text] [PDF]

Home page
 The Diabetes EducatorHome page
E. R. Chasens
Obstructive Sleep Apnea, Daytime Sleepiness, and Type 2 Diabetes
The Diabetes Educator, May 1, 2007; 33(3): 475 - 482.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. F. Drager, L. A. Bortolotto, A. C. Figueiredo, B. C. Silva, E. M. Krieger, and G. Lorenzi-Filho
Obstructive Sleep Apnea, Hypertension, and Their Interaction on Arterial Stiffness and Heart Remodeling
Chest, May 1, 2007; 131(5): 1379 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
V. Patruno, S. Aiolfi, G. Costantino, R. Murgia, C. Selmi, A. Malliani, and N. Montano
Fixed and Autoadjusting Continuous Positive Airway Pressure Treatments Are Not Similar in Reducing Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea
Chest, May 1, 2007; 131(5): 1393 - 1399.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2001 American Thoracic Society 		  Red In Translatin