Am. J. Respir. Crit. Care Med., Volume 162, Number 5, November 2000, 1974-1978

"High Probability" Perfusion Lung Scans in Pulmonary Venoocclusive Disease

COLLEEN L. BAILEY, RICHARD N. CHANNICK, WILLIAM R. AUGER, PETER F. FEDULLO, KIM M. KERR, GORDON L. YUNG, and LEWIS J. RUBIN

Division of Pulmonary and Critical Care Medicine, School of Medicine, University of California, San Diego, California

"High-probability" ventilation/perfusion (/) lung scans generally indicate proximal pulmonary arterial occlusion by thromboemboli or, rarely, other processes such as tumors, fibrosing mediastinitis, or vasculitis. In this report we describe three patients with high probability / scans in whom pulmonary angiography failed to demonstrate arterial occlusion. All three patients were determined to have pulmonary venoocclusive disease (PVOD). In two patients, a tissue diagnosis of PVOD was made, in one case with explanted tissue taken after a successful heart-lung transplant and in the other case with tissue taken at autopsy. PVOD in the third patient was diagnosed with pulmonary venography. A potential explanation for the discrepancy between perfusion lung scan and pulmonary angiographic findings in PVOD is discussed.

This article has been cited by other articles:

				N. Dwyer, R. Smith, D. Challis, D. Reid, and D. Kilpatrick Granulomatous angiitis leading to a pulmonary veno-occlusive disease-like picture Eur. Respir. J., March 1, 2009; 33(3): 666 - 669. [Abstract] [Full Text] [PDF]

				A. A. Frazier, T. J. Franks, T.-L. H. Mohammed, I. H. Ozbudak, and J. R. Galvin From the Archives of the AFIP: Pulmonary Veno-occlusive Disease and Pulmonary Capillary Hemangiomatosis RadioGraphics, May 1, 2007; 27(3): 867 - 882. [Abstract] [Full Text] [PDF]

				R. Coulden State-of-the-Art Imaging Techniques in Chronic Thromboembolic Pulmonary Hypertension Proceedings of the ATS, September 1, 2006; 3(7): 577 - 583. [Abstract] [Full Text] [PDF]

				M. M. Hoeper, E. Mayer, G. Simonneau, and L. J. Rubin Chronic Thromboembolic Pulmonary Hypertension Circulation, April 25, 2006; 113(16): 2011 - 2020. [Full Text] [PDF]

				L. J. Rubin and D. B. Badesch Evaluation and Management of the Patient with Pulmonary Arterial Hypertension Ann Intern Med, August 16, 2005; 143(4): 282 - 292. [Abstract] [Full Text] [PDF]

				M. McGoon, D. Gutterman, V. Steen, R. Barst, D. C. McCrory, T. A. Fortin, and J. E. Loyd Screening, Early Detection, and Diagnosis of Pulmonary Arterial Hypertension: ACCP Evidence-Based Clinical Practice Guidelines Chest, July 1, 2004; 126(1_suppl): 14S - 34S. [Abstract] [Full Text] [PDF]

				P. F. Fedullo, W. R. Auger, K. M. Kerr, and L. J. Rubin Chronic Thromboembolic Pulmonary Hypertension N. Engl. J. Med., November 15, 2001; 345(20): 1465 - 1472. [Full Text] [PDF]

				M. J. TOBIN Chronic Obstructive Pulmonary Disease, Pollution, Pulmonary Vascular Disease, Transplantation, Pleural Disease, and Lung Cancer in AJRCCM 2000 Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1789 - 1804. [Full Text] [PDF]