help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MARSHALL, R. P.
Right arrow Articles by LAURENT, G. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MARSHALL, R. P.
Right arrow Articles by LAURENT, G. J.

Am. J. Respir. Crit. Care Med., Volume 162, Number 5, November 2000, 1783-1788

Fibroproliferation Occurs Early in the Acute Respiratory Distress Syndrome and Impacts on Outcome

RICHARD P. MARSHALL, GEOFFREY BELLINGAN, SUZANNE WEBB, ANNA PUDDICOMBE, NEIL GOLDSACK, ROBIN J. MCANULTY, and GEOFFREY J. LAURENT

Centre for Respiratory Research, Royal Free and University College London Medical School, Rayne Institute, London, United Kingdom

The fibroproliferative phase of acute respiratory distress syndrome (ARDS) has traditionally been regarded as a late event but recent studies that suggest increased lung collagen turnover within 24 h of diagnosis challenge this view. We hypothesized that fibroproliferation is initiated early in ARDS, characterized by the presence of fibroblast growth factor activity in the lung and would relate to clinical outcome. Patients fulfilling American/European Consensus Committee criteria for ARDS and control patients ventilated for non-ARDS respiratory failure underwent bronchoalveolar lavage (BAL) and serum sampling within 24 h of diagnosis and again at 7 d. The ability of BAL fluid (BALF) to stimulate human lung fibroblast proliferation in vitro was examined in relation to concentrations of N-terminal peptide for type III procollagen (N-PCP-III) in BALF/serum and clinical indices. At 24 h, ARDS lavage fluid demonstrated potent mitogenic activity with a median value equivalent to 70% (range 31-164) of the response to serum, and was significantly higher than control lavage (32% of serum response, range 11-42; p < 0.05). At 24 h, serum N-PCP-III concentrations were elevated in the ARDS group compared with control patients (2.8 U/ml; range 0.6-14.8 versus 1.1 U/ml; range 0.4-3.7, p < 0.0001) as were BALF N-PCP-III concentrations (2.9 U/ml; range 0.6-11.4 versus 0.46 U/ ml; range 0.00-1.63, p < 0.01). In addition, BALF N-PCP-III concentrations at 24 h were significantly elevated in nonsurvivors of ARDS compared with survivors (p < 0.05). At 7 d, the mitogenic activity remained elevated in the ARDS group compared with control (p < 0.05) and was also significantly higher in ARDS nonsurvivors compared with survivors (67%; range 45-120 versus 31%; range 16-64, p < 0.05). These data are consistent with the hypothesis that fibroproliferation is an early response to lung injury and an important therapeutic target.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Matute-Bello, C. W. Frevert, and T. R. Martin
Animal models of acute lung injury
Am J Physiol Lung Cell Mol Physiol, September 1, 2008; 295(3): L379 - L399.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Das, N. Burns, S. J. Wilson, W. M. Zawada, and K. R. Stenmark
Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKC{zeta} in the pulmonary artery adventitia
Cardiovasc Res, June 1, 2008; 78(3): 440 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
F. Saito, S. Tasaka, K.-i. Inoue, K. Miyamoto, Y. Nakano, Y. Ogawa, W. Yamada, Y. Shiraishi, N. Hasegawa, S. Fujishima, et al.
Role of Interleukin-6 in Bleomycin-Induced Lung Inflammatory Changes in Mice
Am. J. Respir. Cell Mol. Biol., May 1, 2008; 38(5): 566 - 571.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Quesnel, S. Marchand-Adam, A. Fabre, J. Marchal-Somme, I. Philip, S. Lasocki, V. Lecon, B. Crestani, and M. Dehoux
Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury
Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L334 - L343.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. E. White, Q. Ding, B. B. Moore, M. Peters-Golden, L. B. Ware, M. A. Matthay, and M. A. Olman
Prostaglandin E2 Mediates IL-1 -Related Fibroblast Mitogenic Effects in Acute Lung Injury through Differential Utilization of Prostanoid Receptors
J. Immunol., January 1, 2008; 180(1): 637 - 646.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
I. S. Douglas, F. D. del Valle, R. A. Winn, and N. F. Voelkel
beta-Catenin in the Fibroproliferative Response to Acute Lung Injury
Am. J. Respir. Cell Mol. Biol., March 1, 2006; 34(3): 274 - 285.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. C. Horowitz, Z. Cui, T. A. Moore, T. R. Meier, R. C. Reddy, G. B. Toews, T. J. Standiford, and V. J. Thannickal
Constitutive activation of prosurvival signaling in alveolar mesenchymal cells isolated from patients with nonresolving acute respiratory distress syndrome
Am J Physiol Lung Cell Mol Physiol, March 1, 2006; 290(3): L415 - L425.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. B. Santos, L. K. S. Nagato, N. M. Boechem, E. M. Negri, A. Guimaraes, V. L. Capelozzi, D. S. Faffe, W. A. Zin, and P. R. M. Rocco
Time course of lung parenchyma remodeling in pulmonary and extrapulmonary acute lung injury
J Appl Physiol, January 1, 2006; 100(1): 98 - 106.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
B. S. Burleson and E. D. Maki
Acute Respiratory Distress Syndrome
Journal of Pharmacy Practice, April 1, 2005; 18(2): 118 - 131.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H.-S. Lee, J. M. Lee, M. S. Kim, H. Y. Kim, B. Hwangbo, and J. I. Zo
Low-Dose Steroid Therapy at an Early Phase of Postoperative Acute Respiratory Distress Syndrome
Ann. Thorac. Surg., February 1, 2005; 79(2): 405 - 410.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Rojas, C. R. Woods, A. L. Mora, J. Xu, and K. L. Brigham
Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses
Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L333 - L341.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Olman, K. E. White, L. B. Ware, W. L. Simmons, E. N. Benveniste, S. Zhu, J. Pugin, and M. A. Matthay
Pulmonary Edema Fluid from Patients with Early Lung Injury Stimulates Fibroblast Proliferation through IL-1{beta}-Induced IL-6 Expression
J. Immunol., February 15, 2004; 172(4): 2668 - 2677.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. R. M. Rocco, A. B. Souza, D. S. Faffe, C. P. Passaro, F. B. Santos, E. M. Negri, J. G. M. Lima, R. S. Contador, V. L. Capelozzi, and W. A. Zin
Effect of Corticosteroid on Lung Parenchyma Remodeling at an Early Phase of Acute Lung Injury
Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): 677 - 684.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
W A Dik, R J McAnulty, M A Versnel, B A E Naber, L J I Zimmermann, G J Laurent, and S E Mutsaers
Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats
Thorax, September 1, 2003; 58(9): 765 - 771.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W.A. Dik, M.A. Versnel, B.A. Naber, D.J. Janssen, A.H. van Kaam, and L.J.I. Zimmermann
Dexamethasone treatment does not inhibit fibroproliferation in chronic lung disease of prematurity
Eur. Respir. J., May 1, 2003; 21(5): 842 - 847.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. J. Fahy, F. Lichtenberger, C. B. McKeegan, G. J. Nuovo, C. B. Marsh, and M. D. Wewers
The Acute Respiratory Distress Syndrome: A Role for Transforming Growth Factor-{beta}1
Am. J. Respir. Cell Mol. Biol., April 1, 2003; 28(4): 499 - 503.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. P. Keane, S. C. Donnelly, J. A. Belperio, R. B. Goodman, M. Dy, M. D. Burdick, M. C. Fishbein, and R. M. Strieter
Imbalance in the Expression of CXC Chemokines Correlates with Bronchoalveolar Lavage Fluid Angiogenic Activity and Procollagen Levels in Acute Respiratory Distress Syndrome
J. Immunol., December 1, 2002; 169(11): 6515 - 6521.
[Abstract] [Full Text] [PDF]

Home page
 TraumaHome page
L Tomlinson and G. Bellingan
Trauma and acute lung injury
Trauma, July 1, 2002; 4(3): 147 - 157.
[Abstract] [PDF]

Home page
 ThoraxHome page
G J Bellingan
The pulmonary physician in critical care * 6: The pathogenesis of ALI/ARDS
Thorax, June 1, 2002; 57(6): 540 - 546.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. VILLAGRA, A. OCHAGAVIA, S. VATUA, G. MURIAS, M. DEL MAR FERNANDEZ, J. L. AGUILAR, R. FERNANDEZ, and L. BLANCH
Recruitment Maneuvers during Lung Protective Ventilation in Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 165 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Critical Care Medicine in AJRCCM 2000
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1347 - 1361.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. S. ALHO, K. A. INKINEN, U.-S. SALMINEN, P. K. MAASILTA, E. I. TASKINEN, V. GLUMOFF, E. I. VUORIO, T. S. IKONEN, and A. L. J. HARJULA
Collagens I and III in a Porcine Bronchial Model of Obliterative Bronchiolitis
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1519 - 1525.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society