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Am. J. Respir. Crit. Care Med., Volume 162, Number 4, October 2000, S194-S200

Gene Delivery to the Corneal Endothelium

ANDREW J. T. GEORGE, CAROLINA V. ARANCIBIA-CÁRCAMO, HANNA M. AWAD, RICHARD M. COMER, ZOLTAN FEHEVARI, WILLIAM J. KING, MOHAMMED KADIFACHI, TOBIAS HUDDE, CHRISTELLE KEROUEDAN-LEBOSSÉ, FAREED MIRZA, H. BARBAROS ORAL, SANDRA A. RAYNER, PENG H. TAN, EUGENE TAY, and D. FRANK P. LARKIN

Department of Immunology, Division of Medicine, Imperial College, Hammersmith Hospital, London; and Moorfields Eye Hospital, London, United Kingdom

Gene transfer to the corneal endothelium has potential for modulating rejection of corneal grafts. It can also serve as a convenient and useful model for gene therapy of other organs. In this article we review the work carried out in our laboratory using both viral and nonviral vectors to obtain gene expression in the cornea.




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