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Am. J. Respir. Crit. Care Med., Volume 162, Number 4, October 2000, S185-S189

Control of Experimental Inflammatory Bowel Disease by Regulatory T cells

CHRYSTELLE ASSEMAN, SANNA FOWLER, and FIONA POWRIE

Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immunodeficient mice after transfer of CD45RBhighCD4+ T cells. Development of disease can be prevented by cotransfer of the reciprocal CD45RBlow subset. Analysis of the mechanism of immune suppression transferred by CD45RBlowCD4+ cells revealed essential roles for both IL-10 and TGF-beta . These data indicate that a functionally specialized population of regulatory T (Treg) cells exists in normal mice and that these can prevent the development of pathogenic responses toward commensal bacteria. The role of Treg cells in the control of the immune response is discussed.




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