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Am. J. Respir. Crit. Care Med., Volume 162, Number 4, October 2000, S169-S174

Immunological Tolerance to Inhaled Antigen

GERARD F. HOYNE, KAREN TAN, MARTA CORSIN-JIMENEZ, KAREN WAHL, MAIRI STEWART, SARAH E. M. HOWIE, and JONATHAN R. LAMB

Immunobiology Group, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom

Regulatory mechanisms exist in the immune system to limit the induction of pathogenic responses to antigens encountered within the respiratory tract. The development of allergic disease is thought to arise as a result of the breakdown in these regulatory processes. In this review we examine the nature of immune responses generated to inhaled protein antigens and the mechanisms used to establish tolerance to inhaled antigens.




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