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Am. J. Respir. Crit. Care Med., Volume 162, Number 4, October 2000, S164-S168

Costimulation of T Cells

LAURENCE BUGEON and MARGARET J. DALLMAN

Department of Biology, Imperial College of Science, Technology, and Medicine, London, United Kingdom

Costimulation is critical to T cell activation. On the antigen-presenting cell the key players are found in the extended family of B7 genes comprising cd80, cd86, B7h/B7RP-1 and B7-H1. cd80 and cd86 encode proteins that bind to CD28 and CTLA4 on T cells. Blocking this pathway with the potent CTLA4-Ig fusion protein shows encouraging potential as a therapeutic agent. While cd80 and cd86 pathways act mainly on naive T cells, B7h/B7RP-1 and B7-H1 seem to exert their effects on antigen-experienced lymphocytes.




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