help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BOULET, L.-P.
Right arrow Articles by CHAKIR, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BOULET, L.-P.
Right arrow Articles by CHAKIR, J.

Am. J. Respir. Crit. Care Med., Volume 162, Number 4, October 2000, 1308-1313

Airway Hyperresponsiveness, Inflammation, and Subepithelial Collagen Deposition in Recently Diagnosed versus Long-standing Mild Asthma
Influence of Inhaled Corticosteroids

LOUIS-PHILIPPE BOULET, HÉLÈNE TURCOTTE, MICHEL LAVIOLETTE, FRANÇOISE NAUD, MARIE-CLAUDE BERNIER, SIMON MARTEL, and JAMILA CHAKIR

Institut de Cardiologie et de Pneumologie de L'Université Laval, Hôpital Laval, Sainte-Foy, Québec, Canada

This study aimed at documenting airway inflammation and subepithelial collagen deposition in patients using only inhaled beta 2-agonists with either recently diagnosed asthma (RDA: =< 2 yr, n = 16) or long-standing asthma (LSA: >=  13 yr, n = 16) and at the influence of an intense inhaled corticosteroid (ICS) treatment on these parameters, in relation to changes in airway responsiveness. Patients had a methacholine inhalation test and a bronchoscopy with bronchial biopsies before and after an 8-wk treatment with inhaled fluticasone propionate (FP), 1,000 µg/day. Baseline FEV1 (mean ± SEM) was normal and similar in both groups (RDA: 98.1 ± 2.7, LSA: 94.5 ± 4.6%). Geometric mean methacholine PC20 was lower in LSA than in RDA (0.44 versus 3.37 mg/ml) at baseline and improved similarly by 1.85 and 1.86 double concentrations with FP treatment. PC20 normalized (>=  16 mg/ml) in five patients with RDA and two patients with LSA. Baseline mean bronchial cell counts (per mm2 connective tissue surface) for CD3+, CD4+, CD8+, CD25+, EG1+, CD45ro+, and AA1+ cells were similar in both groups. With FP, EG1+ (p < 0.001), EG2+ (p = 0.018), and AA1+ counts (p = 0.009) decreased significantly in both groups while CD45ro+ (p = 0.02) counts decreased only in LSA. Baseline type 1 and type 3 collagen deposition underneath the basement membrane was similar in RDA and LSA and did not change significantly after FP. This study shows that recent compared to long-standing mild asthma is associated with a similar degree of airway inflammation and subepithelial fibrosis, and a similar improvement in airway hyperresponsiveness after 8 wk on high-dose ICS. It also indicates that once asthma becomes symptomatic, airway responsiveness cannot normalize in most subjects over such a time period, even with a high dose of ICS.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
D. C. M. Simoes, G. Xanthou, K. Petrochilou, V. Panoutsakopoulou, C. Roussos, and C. Gratziou
Osteopontin Deficiency Protects against Airway Remodeling and Hyperresponsiveness in Chronic Asthma
Am. J. Respir. Crit. Care Med., May 15, 2009; 179(10): 894 - 902.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. A. Doherty, P. Soroosh, D. H. Broide, and M. Croft
CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling
Am J Physiol Lung Cell Mol Physiol, February 1, 2009; 296(2): L229 - L235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. R. Johnson, S. R. Pacitto, J. Wong, E. W. Archer, S. Eirefelt, A. Miller-Larsson, and M. Jordana
Combined budesonide/formoterol therapy in conjunction with allergen avoidance ameliorates house dust mite-induced airway remodeling and dysfunction
Am J Physiol Lung Cell Mol Physiol, November 1, 2008; 295(5): L780 - L788.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. S. Southam, R. Ellis, J. Wattie, S. Young, and M. D. Inman
Budesonide prevents but does not reverse sustained airway hyperresponsiveness in mice
Eur. Respir. J., October 1, 2008; 32(4): 970 - 978.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. van den Nieuwenhof, T. Schermer, Y. Heijdra, B. Bottema, R. Akkermans, H. Folgering, and C. van Weel
Are asymptomatic airway hyperresponsiveness and allergy risk factors for asthma? A longitudinal study
Eur. Respir. J., July 1, 2008; 32(1): 70 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. R. Johnson, F. K. Swirski, B. U. Gajewska, R. E. Wiley, R. Fattouh, S. R. Pacitto, J. K. Wong, M. R. Stampfli, and M. Jordana
Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes
Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L730 - L739.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. M. Lloyd and D. S. Robinson
Allergen-induced airway remodelling
Eur. Respir. J., May 1, 2007; 29(5): 1020 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. M. Kelly, J. Chakir, D. Vethanayagam, L.-P. Boulet, M. Laviolette, J. Gauldie, and P. M. O'Byrne
Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge.
Chest, September 1, 2006; 130(3): 741 - 753.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Bergeron and L.-P. Boulet
Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation.
Chest, April 1, 2006; 129(4): 1068 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P Ernst
Inhaled corticosteroids moderate lung function decline in adults with asthma
Thorax, February 1, 2006; 61(2): 93 - 94.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
L. Todorova, E. Gurcan, A. Miller-Larsson, and G. Westergren-Thorsson
Lung Fibroblast Proteoglycan Production Induced by Serum Is Inhibited by Budesonide and Formoterol
Am. J. Respir. Cell Mol. Biol., January 1, 2006; 34(1): 92 - 100.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Miller, J. Y. Cho, K. McElwain, S. McElwain, J. Y. Shim, M. Manni, J. S. Baek, and D. H. Broide
Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice
Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L162 - L169.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
R. J. Homer and J. A. Elias
Airway Remodeling in Asthma: Therapeutic Implications of Mechanisms
Physiology, February 1, 2005; 20(1): 28 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. M. Kelly, R. Leigh, P. Bonniaud, R. Ellis, J. Wattie, M. J. Smith, G. Martin, M. Panju, M. D. Inman, and J. Gauldie
Epithelial Expression of Profibrotic Mediators in a Model of Allergen-Induced Airway Remodeling
Am. J. Respir. Cell Mol. Biol., February 1, 2005; 32(2): 99 - 107.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Leigh, D. S. Southam, R. Ellis, J. N. Wattie, R. Sehmi, Y. Wan, and M. D. Inman
T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice
J Appl Physiol, December 1, 2004; 97(6): 2258 - 2265.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. Chanez, A. Bourdin, I. Vachier, P. Godard, J. Bousquet, and A. M. Vignola
Effects of Inhaled Corticosteroids on Pathology in Asthma and Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, November 1, 2004; 1(3): 184 - 190.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Leigh, R. Ellis, J. Wattie, D. D. Donaldson, and M. D. Inman
Is Interleukin-13 Critical in Maintaining Airway Hyperresposiveness in Allergen-challenged Mice?
Am. J. Respir. Crit. Care Med., October 15, 2004; 170(8): 851 - 856.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. Tamaoki, E. Tagaya, K. Kawatani, J. Nakata, Y. Endo, and A. Nagai
Airway Mucosal Thickening and Bronchial Hyperresponsiveness Induced by Inhaled {beta}2-Agonist in Mice
Chest, July 1, 2004; 126(1): 205 - 212.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
G. Riccioni, C. Di Ilio, and N. D'Orazio
Pharmacological Treatment of Airway Remodeling: Inhaled Corticosteroids or Antileukotrienes?
Ann. Clin. Lab. Sci., April 1, 2004; 34(2): 138 - 142.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Leigh, R. Ellis, J. N. Wattie, J. A. Hirota, K. I. Matthaei, P. S. Foster, P. M. O'Byrne, and M. D. Inman
Type 2 Cytokines in the Pathogenesis of Sustained Airway Dysfunction and Airway Remodeling in Mice
Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 860 - 867.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. R. Johnson, R. E. Wiley, R. Fattouh, F. K. Swirski, B. U. Gajewska, A. J. Coyle, J.-C. Gutierrez-Ramos, R. Ellis, M. D. Inman, and M. Jordana
Continuous Exposure to House Dust Mite Elicits Chronic Airway Inflammation and Structural Remodeling
Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 378 - 385.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. C. Pitchford, Y. Riffo-Vasquez, A. Sousa, S. Momi, P. Gresele, D. Spina, and C. P. Page
Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation
Blood, January 15, 2004; 103(2): 639 - 647.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L.-P. Boulet
Asymptomatic Airway Hyperresponsiveness: A Curiosity or an Opportunity to Prevent Asthma?
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 371 - 378.
[Full Text] [PDF]

Home page
 ThoraxHome page
P A Beckett and P H Howarth
Pharmacotherapy and airway remodelling in asthma?
Thorax, February 1, 2003; 58(2): 163 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A.S. Buist
Similarities and differences between asthma and chronic obstructive pulmonary disease: treatment and early outcomes
Eur. Respir. J., January 1, 2003; 21(39_suppl): 30S - 35s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. L. James, P. S. Maxwell, G. Pearce-Pinto, J. G. Elliot, and N. G. Carroll
The Relationship of Reticular Basement Membrane Thickness to Airway Wall Remodeling in Asthma
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1590 - 1595.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. Leigh, R. Ellis, J. Wattie, D. S. Southam, M. de Hoogh, J. Gauldie, P. M. O'Byrne, and M. D. Inman
Dysfunction and Remodeling of the Mouse Airway Persist after Resolution of Acute Allergen-Induced Airway Inflammation
Am. J. Respir. Cell Mol. Biol., November 1, 2002; 27(5): 526 - 535.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. Shiba, K. Kasahara, H. Nakajima, and M. Adachi
Structural Changes of the Airway Wall Impair Respiratory Function, Even in Mild Asthma
Chest, November 1, 2002; 122(5): 1622 - 1626.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
N.J. Vanacker, E. Palmans, R.A. Pauwels, and J.C. Kips
Dose-related effect of inhaled fluticasone on allergen-induced airway changes in rats
Eur. Respir. J., October 1, 2002; 20(4): 873 - 879.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. G. Apostol, D. R. Jacobs Jr., A. W. Tsai, R. S. Crow, O. D. Williams, M. C. Townsend, and W. S. Beckett
Early Life Factors Contribute to the Decrease in Lung Function between Ages 18 and 40: The Coronary Artery Risk Development in Young Adults Study
Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 166 - 172.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
C Ward, M Pais, R Bish, D Reid, B Feltis, D Johns, and E H Walters
Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma
Thorax, April 1, 2002; 57(4): 309 - 316.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Allergic Rhinitis in AJRCCM 2000
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1559 - 1580.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. WARD, D. P. JOHNS, R. BISH, M. PAIS, D. W. REID, C. INGRAM, B. FELTIS, and E. HAYDN WALTERS
Reduced Airway Distensibility, Fixed Airflow Limitation, and Airway Wall Remodeling in Asthma
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1718 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. C. Kips
Treating Asthma, or Is Simple Too Simple?
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1336 - 1338.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. BENAYOUN, S. LETUVE, A. DRUILHE, J. BOCZKOWSKI, M.-C. DOMBRET, P. MECHIGHEL, J. MEGRET, G. LESECHE, M. AUBIER, and M. PRETOLANI
Regulation of Peroxisome Proliferator-activated Receptor gamma Expression in Human Asthmatic Airways . Relationship with Proliferation, Apoptosis, and Airway Remodeling
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1487 - 1494.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society 		  CCM abstracts