Am. J. Respir. Crit. Care Med., Volume 162, Number 2, August 2000, 393-398

Improvements in Outcomes of Acute Respiratory Failure for Patients with Human Immunodeficiency Virus-related Pneumocystis carinii Pneumonia

J. RANDALL CURTIS, PAUL R. YARNOLD, DAVID N. SCHWARTZ, ROBERT A. WEINSTEIN, and CHARLES L. BENNETT

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington; Division of General Medicine, Northwestern University Medical School, Evanston, Illinois; Cook County Hospital, Rush Medical College, Chicago, Illinois; and Chicago VA Healthcare System/Lakeside Division and the Department of Medicine, the Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois

In the early 1990s, hospital survival among patients with human immunodeficiency virus (HIV)-related Pneumocystis carinii pneumonia (PCP) and respiratory failure was poor, approximately 20%. We examined ICU use and outcomes for patients with acute respiratory failure from PCP from 1995 to 1997. We conducted a retrospective medical record review using a random sample of 71 hospitals in seven regions of the United States. Among 1,660 patients with confirmed or presumed PCP, 155 (9%) received mechanical ventilation for respiratory failure. Factors that predicted use of mechanical ventilation, independent of severity of illness on hospital admission, included African-American ethnicity and geographic location (p  0.002). Hospital survival for patients receiving mechanical ventilation was 38% (95% CI 30, 46). Controlling for severity of illness, patients who were on PCP prophylaxis prior to developing PCP were less likely to survive to hospital discharge (p  0.02). There were no significant differences in hospital survival regardless of whether patients had received less than or more than 5 d of PCP treatment prior to respiratory failure (39 versus 29%; p = 0.5). In conclusion, from 1995 to 1997, hospital survival after PCP requiring mechanical ventilation was approximately 40%. Physicians caring for patients with severe HIV-related PCP should be aware of the improvements in outcomes for this disease before making recommendations about withholding or withdrawing ventilatory support for respiratory failure.

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