help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PAREDI, P.
Right arrow Articles by BARNES, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PAREDI, P.
Right arrow Articles by BARNES, P. J.

Am. J. Respir. Crit. Care Med., Volume 162, Number 2, August 2000, 369-373

Exhaled Ethane, a Marker of Lipid Peroxidation, Is Elevated in Chronic Obstructive Pulmonary Disease

PAOLO PAREDI, SERGEI A. KHARITONOV, DAVID LEAK, SIMON WARD, DAVID CRAMER, and PETER J. BARNES

Department of Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute; Department of Biochemistry, Imperial College of Science, Technology and Medicine; and Lung Function Unit, Royal Brompton Hospital, London, United Kingdom

Ethane is a product of lipid peroxidation and can be measured in the exhaled air as an index of oxidative stress. Oxidant/antioxidant imbalance is important in the pathogenesis of chronic obstructive pulmonary disease (COPD). Therefore, we measured exhaled ethane in 22 patients with COPD (mean age ± SEM, 59 ± 8 yr; 19 male) and compared it with other noninvasive markers of oxidative stress and inflammation such as carbon monoxide (CO), measured electrochemically, and nitric oxide (NO), measured by chemiluminescence. Exhaled ethane was collected during a flow and pressure-controlled exhalation into a reservoir, discarding dead space air contaminated with ambient air. A sample of the collected expired air was analyzed by chromatography. Compared with normal subjects (n = 14; eight men; age, 33 ± 2.8 yr), patients with COPD not on steroid treatment (n = 12; FEV1, 58 ± 6%) had elevated levels of exhaled ethane (2.77 ± 0.25 and 0.88 ± 0.09 ppb, respectively, p < 0.05), CO (5.96 ± 0.50 and 2.8 ± 0.25 ppm, p < 0.05) and NO (11.86 ± 0.53 and 6.77 ± 0.50 ppb, p < 0.05) levels. Ethane was correlated to FEV1 (r = -0.67, p < 0.05). Patients receiving steroid treatment (n = 10; FEV1, 56 ± 2%) had lower levels of ethane (0.48 ± 0.05 ppb) than did steroid-treated patients, whereas CO (5.99 ± 0.63 ppm) and NO (9.11 ± 0.53 ppb) levels were similar in the two treatment groups. Exhaled ethane is elevated, correlates with FEV1, and is significantly lower in patients treated with steroids, so it may be complementary to the use of NO and CO in assessing and monitoring oxidative stress in COPD.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes
Defective Antioxidant Gene Regulation in COPD: A Case for Broccoli
Am. J. Respir. Crit. Care Med., September 15, 2008; 178(6): 552 - 554.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al.
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Eur. Respir. J., February 1, 2008; 31(2): 416 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. Bathoorn, D-J. Slebos, D. S. Postma, G. H. Koeter, A. J. M. van Oosterhout, M. van der Toorn, H. M. Boezen, and H. A. M. Kerstjens
Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study
Eur. Respir. J., December 1, 2007; 30(6): 1131 - 1137.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. Paredi, S. Ward, D. Cramer, P. J. Barnes, and S. A. Kharitonov
Normal Bronchial Blood Flow in COPD Is Unaffected by Inhaled Corticosteroids and Correlates With Exhaled Nitric Oxide
Chest, April 1, 2007; 131(4): 1075 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes, B. Chowdhury, S. A. Kharitonov, H. Magnussen, C. P. Page, D. Postma, and M. Saetta
Pulmonary Biomarkers in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 1, 2006; 174(1): 6 - 14.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
K Nagai, T Betsuyaku, T Kondo, Y Nasuhara, and M Nishimura
Long term smoking with age builds up excessive oxidative stress in bronchoalveolar lavage fluid
Thorax, June 1, 2006; 61(6): 496 - 502.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
W. Cao and Y. Duan
Breath Analysis: Potential for Clinical Diagnosis and Exposure Assessment
Clin. Chem., May 1, 2006; 52(5): 800 - 811.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
H. M. Ochs-Balcom, B. J. B. Grant, P. Muti, C. T. Sempos, J. L. Freudenheim, R. W. Browne, M. Trevisan, L. Iacoviello, P. A. Cassano, and H. J. Schunemann
Oxidative Stress and Pulmonary Function in the General Population
Am. J. Epidemiol., December 15, 2005; 162(12): 1137 - 1145.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
I. M. Adcock and K. Ito
Glucocorticoid Pathways in Chronic Obstructive Pulmonary Disease Therapy
Proceedings of the ATS, November 1, 2005; 2(4): 313 - 319.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Kanoh, H. Kobayashi, and K. Motoyoshi
Exhaled Ethane: An In Vivo Biomarker of Lipid Peroxidation in Interstitial Lung Diseases
Chest, October 1, 2005; 128(4): 2387 - 2392.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
P. J. Barnes
New approaches to COPD
Eur. Respir. Rev., September 1, 2005; 14(94): 2 - 11.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
W. MacNee
Treatment of stable COPD: antioxidants
Eur. Respir. Rev., September 1, 2005; 14(94): 12 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. J. Barnes and R. A. Stockley
COPD: current therapeutic interventions and future approaches
Eur. Respir. J., June 1, 2005; 25(6): 1084 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Yasuda, M. Yamaya, K. Nakayama, S. Ebihara, T. Sasaki, S. Okinaga, D. Inoue, M. Asada, M. Nemoto, and H. Sasaki
Increased Arterial Carboxyhemoglobin Concentrations in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 1, 2005; 171(11): 1246 - 1251.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Santus, A. Sola, P. Carlucci, F. Fumagalli, A. Di Gennaro, M. Mondoni, C. Carnini, S. Centanni, and A. Sala
Lipid Peroxidation and 5-Lipoxygenase Activity in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 838 - 843.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
W. MacNee
Pulmonary and Systemic Oxidant/Antioxidant Imbalance in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2005; 2(1): 50 - 60.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. F. P. Man and D. D. Sin
Effects of Corticosteroids on Systemic Inflammation in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2005; 2(1): 78 - 82.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
E M Drost, K M Skwarski, J Sauleda, N Soler, J Roca, A Agusti, and W MacNee
Oxidative stress and airway inflammation in severe exacerbations of COPD
Thorax, April 1, 2005; 60(4): 293 - 300.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. J. Barnes, I. M. Adcock, and K. Ito
Histone acetylation and deacetylation: importance in inflammatory lung diseases
Eur. Respir. J., March 1, 2005; 25(3): 552 - 563.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
C M Harrison and C C Andersen
Exhaled breath measures of inflammation: are they useful in neonatal chronic lung disease?
Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2005; 90(1): F6 - F10.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Corradi, P. Pignatti, P. Manini, R. Andreoli, M. Goldoni, M. Poppa, G. Moscato, B. Balbi, and A. Mutti
Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation
Eur. Respir. J., December 1, 2004; 24(6): 1011 - 1017.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
P. J. Barnes
Mediators of Chronic Obstructive Pulmonary Disease
Pharmacol. Rev., December 1, 2004; 56(4): 515 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. A. Kharitonov and P. J. Barnes
Effects of Corticosteroids on Noninvasive Biomarkers of Inflammation in Asthma and Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, November 1, 2004; 1(3): 191 - 199.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. Beilman
Exhaled Nitric Oxide in Pathophysiologic States: The Substance Behind the Gas
Chest, January 1, 2004; 125(1): 11 - 13.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
R. Zegdi, O. Fabre, N. Lila, P. Fornes, M. Cambillau, M. Shen, P. Herve, A. Carpentier, and J.-N. Fabiani
Exhaled carbon monoxide and inducible heme oxygenase expression in a rat model of postperfusion acute lung injury
J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1867 - 1874.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. von Basum, H. Dahnke, D. Halmer, P. Hering, and M. Murtz
Online recording of ethane traces in human breath via infrared laser spectroscopy
J Appl Physiol, December 1, 2003; 95(6): 2583 - 2590.
[Abstract] [Full Text]

Home page
 Eur Respir JHome page
A.W. Boots, G.R.M.M. Haenen, and A. Bast
Oxidant metabolism in chronic obstructive pulmonary disease
Eur. Respir. J., November 2, 2003; 22(46_suppl): 14s - 27s.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P J Barnes
Chronic obstructive pulmonary disease * 12: New treatments for COPD
Thorax, September 1, 2003; 58(9): 803 - 808.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
V. L. Kinnula and J. D. Crapo
Superoxide Dismutases in the Lung and Human Lung Diseases
Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1600 - 1619.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Corradi, I. Rubinstein, R. Andreoli, P. Manini, A. Caglieri, D. Poli, R. Alinovi, and A. Mutti
Aldehydes in Exhaled Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1380 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
W A Biernacki, S A Kharitonov, and P J Barnes
Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD
Thorax, April 1, 2003; 58(4): 294 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Paredi, G. Caramori, D. Cramer, S. Ward, A. Ciaccia, A. Papi, S.A. Kharitonov, and P.J. Barnes
Slower rise of exhaled breath temperature in chronic obstructive pulmonary disease
Eur. Respir. J., March 1, 2003; 21(3): 439 - 443.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Paredi, S. A. Kharitonov, and P. J. Barnes
Analysis of Expired Air for Oxidation Products
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): S31 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. P. Bowler and J. D. Crapo
Oxidative Stress in Airways: Is There a Role for Extracellular Superoxide Dismutase?
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): S38 - 43.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Rahman, A. A. M. van Schadewijk, A. J. L. Crowther, P. S. Hiemstra, J. Stolk, W. MacNee, and W. I. De Boer
4-Hydroxy-2-Nonenal, a Specific Lipid Peroxidation Product, Is Elevated in Lungs of Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 490 - 495.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Chronic Obstructive Pulmonary Disease, Pollution, Pulmonary Vascular Disease, Transplantation, Pleural Disease, and Lung Cancer in AJRCCM 2000
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1789 - 1804.
[Full Text] [PDF]

Home page
 ChestHome page
P. Montuschi, S. A. Kharitonov, and P. J. Barnes
Exhaled Carbon Monoxide and Nitric Oxide in COPD
Chest, August 1, 2001; 120(2): 496 - 501.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. A. KHARITONOV and P. J. BARNES
Exhaled Markers of Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1693 - 1722.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society