Am. J. Respir. Crit. Care Med., Volume 161, Number 6, June 2000, 1830-1835

Respiratory-related Evoked Potentials in Children with Life-threatening Asthma

PAUL W. DAVENPORT, MAURICE CRUZ,^* ARLENE A. STECENKO, and YEMISERACH KIFLE

Departments of Pediatrics and Physiological Sciences, University of Florida, Gainesville, Florida

Respiratory-related evoked potentials (RREPs) have been elicited by inspiratory occlusion and recorded over the somatosensory cortex. The first positive peak (P₁) amplitude has been correlated with the magnitude of inspiratory loads. Since children with life-threatening asthma (LTA) have a decreased perceptual sensitivity of inspiratory loads, we hypothesized that a subpopulation of patients with LTA have an impaired ability to sense mechanical loads, and that these patients would have an abnormal RREP. The RREP was recorded from C_Z -C₃ and C_Z -C₄ in three groups: LTA asthmatic, control asthmatic, and nonasthmatic children. Two inspiratory-interruption occlusions trials and a control trial were recorded. All the evoked potentials were analyzed after the averaged control trial was subtracted from the averaged occlusion trials. The RREP P₁ peak was observed in all 14 nonasthmatic children and in 14 of 15 control asthmatic children. The RREP was absent in 6 of 11 patients with LTA. When present, there were no between-group significant differences in P₁ peak latency or amplitude. These results demonstrate that the RREP elicited by inspiratory occlusion is present bilaterally in nonasthmatic and asthmatic children. There is a subpopulation of LTA children in which inspiratory occlusion fails to elicit the P₁ peak of the RREP, suggesting an altered neural processing of inspiratory load information.

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