help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SIGURS, N.
Right arrow Articles by KJELLMAN, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SIGURS, N.
Right arrow Articles by KJELLMAN, B.

Am. J. Respir. Crit. Care Med., Volume 161, Number 5, May 2000, 1501-1507

Respiratory Syncytial Virus Bronchiolitis in Infancy Is an Important Risk Factor for Asthma and Allergy at Age 7 

NELE SIGURS, RAGNAR BJARNASON, FRIDRIK SIGURBERGSSON, and BENGT KJELLMAN

Department of Pediatrics, Borås Central Hospital, Borås, Sweden; Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden; Emergency Department, Reykjavik Hospital, Reykjavik, Iceland; and Department of Pediatrics, Skövde Central Hospital, Skövde, Sweden

We previously reported an increased risk for bronchial obstructive disease and allergic sensitization up to age 3 in 47 children hospitalized with a respiratory syncytial virus (RSV) bronchiolitis in infancy compared with 93 matched control subjects recruited during infancy. The aims of the present study were to evaluate the occurrences of bronchial obstructive disease and allergic sensitization in these children at age 71/ 2. All 140 children reported for the follow-up, which included physical examination, skin prick tests, and serum IgE tests for common food and inhaled allergens. The cumulative prevalence of asthma was 30% in the RSV group and 3% in the control group (p < 0.001), and the cumulative prevalence of "any wheezing" was 68% and 34%, respectively (p < 0.001). Asthma during the year prior to follow-up was seen in 23% of the RSV children and 2% in the control subjects (p < 0.001). Allergic sensitization was found in 41% of the RSV children and 22% of the control subjects (p = 0.039). Multivariate evaluation of possible risk factors for asthma and sensitization using a stepwise logistic statistical procedure for all 140 children showed that RSV bronchiolitis had the highest independent risk ratio for asthma (OR: 12.7, 95% CI 3.4 to 47.1) and a significantly elevated independent risk ratio for allergic sensitization (OR: 2.4, 95% CI 1.1 to 5.5). In conclusion, RSV bronchiolitis in infancy severe enough to cause hospitalization was highly associatied with the development of asthma and allergic sensitization up to age 71/ 2. The results support the theory that the RSV influences the mechanisms involved in the development of asthma and allergy in children.




This article has been cited by other articles:


Home page
 J. Gen. Virol.Home page
J. Kovacs-Nolan, J. W. Mapletoft, Z. Lawman, L. A. Babiuk, and S. van Drunen Littel-van den Hurk
Formulation of bovine respiratory syncytial virus fusion protein with CpG oligodeoxynucleotide, cationic host defence peptide and polyphosphazene enhances humoral and cellular responses and induces a protective type 1 immune response in mice
J. Gen. Virol., August 1, 2009; 90(8): 1892 - 1905.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. F. Thomsen, S. van der Sluis, L. G. Stensballe, D. Posthuma, A. Skytthe, K. O. Kyvik, D. L. Duffy, V. Backer, and H. Bisgaard
Exploring the Association between Severe Respiratory Syncytial Virus Infection and Asthma: A Registry-based Twin Study
Am. J. Respir. Crit. Care Med., June 15, 2009; 179(12): 1091 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
T. Okabayashi, S.-i. Yokota, Y. Yoto, H. Tsutsumi, and N. Fujii
Fosfomycin Suppresses Chemokine Induction in Airway Epithelial Cells Infected with Respiratory Syncytial Virus
Clin. Vaccine Immunol., June 1, 2009; 16(6): 859 - 865.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A Greenough, J Alexander, P Boit, J Boorman, S Burgess, A Burke, P A Chetcuti, I Cliff, W Lenney, T Lytle, et al.
School age outcome of hospitalisation with respiratory syncytial virus infection of prematurely born infants
Thorax, June 1, 2009; 64(6): 490 - 495.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2008
Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 637 - 649.
[Full Text] [PDF]

Home page
 PediatricsHome page
J. M. Mansbach, J. A. Espinola, C. G. Macias, M. E. Ruhlen, A. F. Sullivan, and C. A. Camargo Jr
Variability in the Diagnostic Labeling of Nonbacterial Lower Respiratory Tract Infections: A Multicenter Study of Children Who Presented to the Emergency Department
Pediatrics, April 1, 2009; 123(4): e573 - e581.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Wu, W. D. Dupont, M. R. Griffin, K. N. Carroll, E. F. Mitchel, T. Gebretsadik, and T. V. Hartert
Evidence of a Causal Role of Winter Virus Infection during Infancy in Early Childhood Asthma
Am. J. Respir. Crit. Care Med., December 1, 2008; 178(11): 1123 - 1129.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
I. Amirav, A. S. Luder, N. Kruger, Y. Borovitch, I. Babai, D. Miron, M. Zuker, G. Tal, and A. Mandelberg
A Double-Blind, Placebo-Controlled, Randomized Trial of Montelukast for Acute Bronchiolitis
Pediatrics, December 1, 2008; 122(6): e1249 - e1255.
[Abstract] [Full Text] [PDF]

Home page
 Am J Health Syst PharmHome page
R. F. Robinson
Impact of respiratory syncytial virus in the United States
Am. J. Health Syst. Pharm., December 1, 2008; 65(23_Supplement_8): S3 - S6.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
A. Henderson
What have we learned from prospective cohort studies of asthma in children?
Chronic Respiratory Disease, November 1, 2008; 5(4): 225 - 231.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. J. Jackson, R. E. Gangnon, M. D. Evans, K. A. Roberg, E. L. Anderson, T. E. Pappas, M. C. Printz, W.-M. Lee, P. A. Shult, E. Reisdorf, et al.
Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children
Am. J. Respir. Crit. Care Med., October 1, 2008; 178(7): 667 - 672.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. You, M. Ripple, S. Balakrishna, D. Troxclair, D. Sandquist, L. Ding, T. A. Ahlert, and S. A. Cormier
Inchoate CD8+ T Cell Responses in Neonatal Mice Permit Influenza-Induced Persistent Pulmonary Dysfunction
J. Immunol., September 1, 2008; 181(5): 3486 - 3494.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
S. S. Mohapatra and S. Boyapalle
Epidemiologic, Experimental, and Clinical Links between Respiratory Syncytial Virus Infection and Asthma
Clin. Microbiol. Rev., July 1, 2008; 21(3): 495 - 504.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2007
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 686 - 695.
[Full Text] [PDF]

Home page
 J. Virol.Home page
J. Eckardt-Michel, M. Lorek, D. Baxmann, T. Grunwald, G. M. Keil, and G. Zimmer
The Fusion Protein of Respiratory Syncytial Virus Triggers p53-Dependent Apoptosis
J. Virol., April 1, 2008; 82(7): 3236 - 3249.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. M. Akk, P. M. Simmons, H. W. Chan, E. Agapov, M. J. Holtzman, M. H. Grayson, and C. T. N. Pham
Dipeptidyl Peptidase I-Dependent Neutrophil Recruitment Modulates the Inflammatory Response to Sendai Virus Infection
J. Immunol., March 1, 2008; 180(5): 3535 - 3542.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y.-M. Lee, N. Miyahara, K. Takeda, J. Prpich, A. Oh, A. Balhorn, A. Joetham, E. W. Gelfand, and A. Dakhama
IFN-{gamma} Production during Initial Infection Determines the Outcome of Reinfection with Respiratory Syncytial Virus
Am. J. Respir. Crit. Care Med., January 15, 2008; 177(2): 208 - 218.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Shiraishi, K. Asano, K. Niimi, K. Fukunaga, M. Wakaki, J. Kagyo, T. Takihara, S. Ueda, T. Nakajima, T. Oguma, et al.
Cyclooxygenase-2/Prostaglandin D2/CRTH2 Pathway Mediates Double-Stranded RNA-Induced Enhancement of Allergic Airway Inflammation
J. Immunol., January 1, 2008; 180(1): 541 - 549.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. S. Boukhvalova, G. A. Prince, and J. C. G. Blanco
Respiratory Syncytial Virus Infects and Abortively Replicates in the Lungs in Spite of Preexisting Immunity
J. Virol., September 1, 2007; 81(17): 9443 - 9450.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
S. Broughton, M. R Thomas, L. Marston, S. A Calvert, N. Marlow, J. L Peacock, G. F Rafferty, and A. Greenough
Very prematurely born infants wheezing at follow-up: lung function and risk factors
Arch. Dis. Child., September 1, 2007; 92(9): 776 - 780.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
W.-M. Lee, K. Grindle, T. Pappas, D. J. Marshall, M. J. Moser, E. L. Beaty, P. A. Shult, J. R. Prudent, and J. E. Gern
High-Throughput, Sensitive, and Accurate Multiplex PCR-Microsphere Flow Cytometry System for Large-Scale Comprehensive Detection of Respiratory Viruses
J. Clin. Microbiol., August 1, 2007; 45(8): 2626 - 2634.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. M. Monick, L. S. Powers, I. Hassan, D. Groskreutz, T. O. Yarovinsky, C. W. Barrett, E. M. Castilow, D. Tifrea, S. M. Varga, and G. W. Hunninghake
Respiratory Syncytial Virus Synergizes with Th2 Cytokines to Induce Optimal Levels of TARC/CCL17
J. Immunol., August 1, 2007; 179(3): 1648 - 1658.
[Abstract] [Full Text] [PDF]

Home page
 AAP Grand RoundsHome page
M. R. Lester
Analysis of Steroid Treatment of First Wheezing Episode
AAP Grand Rounds, July 1, 2007; 18(1): 6 - 7.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. Yoo, H. Tcheurekdjian, S. V. Lynch, M. Cabana, and H. A. Boushey
Microbial Manipulation of Immune Function for Asthma Prevention: Inferences from Clinical Trials
Proceedings of the ATS, July 1, 2007; 4(3): 277 - 282.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
H. B. Panitch
The Relationship Between Early Respiratory Viral Infections and Subsequent Wheezing and Asthma
Clinical Pediatrics, June 1, 2007; 46(5): 392 - 400.
[PDF]

Home page
 Eur Respir JHome page
M. U. Pereira, P. D. Sly, P. M. Pitrez, M. H. Jones, D. Escouto, A. C. O. Dias, S. K. Weiland, and R. T. Stein
Nonatopic asthma is associated with helminth infections and bronchiolitis in poor children
Eur. Respir. J., June 1, 2007; 29(6): 1154 - 1160.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
K. N. Carroll, T. Gebretsadik, M. R. Griffin, W. D. Dupont, E. F. Mitchel, P. Wu, R. Enriquez, and T. V. Hartert
Maternal Asthma and Maternal Smoking Are Associated With Increased Risk of Bronchiolitis During Infancy
Pediatrics, June 1, 2007; 119(6): 1104 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 AAP Grand RoundsHome page
A. Fimbres
Do Early Infections Protect Against Development of Childhood Atopy?
AAP Grand Rounds, April 1, 2007; 17(4): 46 - 47.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. M. Singh, P. E. Moore, J. E. Gern, R. F. Lemanske Jr., and T. V. Hartert
Bronchiolitis to Asthma: A Review and Call for Studies of Gene-Virus Interactions in Asthma Causation
Am. J. Respir. Crit. Care Med., January 15, 2007; 175(2): 108 - 119.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. Proud and C.-W. Chow
Role of Viral Infections in Asthma and Chronic Obstructive Pulmonary Disease
Am. J. Respir. Cell Mol. Biol., November 1, 2006; 35(5): 513 - 518.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
N. O. ElHassan, M. E. S. Sorbero, C. B. Hall, T. P. Stevens, and A. W. Dick
Cost-effectiveness Analysis of Palivizumab in Premature Infants Without Chronic Lung Disease.
Arch Pediatr Adolesc Med, October 1, 2006; 160(10): 1070 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Wang, N. Peters, V. Laza-Stanca, N. Nawroly, S. L. Johnston, and J. Schwarze
Local CD11c+ MHC Class II- Precursors Generate Lung Dendritic Cells during Respiratory Viral Infection, but Are Depleted in the Process
J. Immunol., August 15, 2006; 177(4): 2536 - 2542.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
T H Harju, M Leinonen, J Nokso-Koivisto, T Korhonen, R Raty, Q He, T Hovi, J Mertsola, A Bloigu, P Rytila, et al.
Pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma
Thorax, July 1, 2006; 61(7): 579 - 584.
[Abstract] [Full Text] [PDF]

Home page
 J Clin PharmacolHome page
B. Knorr, L. Maganti, R. Ramakrishnan, C. A. Tozzi, E. Migoya, and G. Kearns
Pharmacokinetics and safety of montelukast in children aged 3 to 6 months.
J. Clin. Pharmacol., June 1, 2006; 46(6): 620 - 627.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. Chi, H. L. Dickensheets, K. M. Spann, M. A. Alston, C. Luongo, L. Dumoutier, J. Huang, J.-C. Renauld, S. V. Kotenko, M. Roederer, et al.
Alpha and Lambda Interferon Together Mediate Suppression of CD4 T Cells Induced by Respiratory Syncytial Virus
J. Virol., May 15, 2006; 80(10): 5032 - 5040.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. Phaybouth, S.-Z. Wang, J. A. Hutt, J. D. McDonald, K. S. Harrod, and E. G. Barrett
Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model
Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L222 - L231.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
S Broughton, R Bhat, A Roberts, M Zuckerman, G Rafferty, and A Greenough
Diminished lung function, RSV infection, and respiratory morbidity in prematurely born infants
Arch. Dis. Child., January 1, 2006; 91(1): 26 - 30.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Broughton, A Roberts, G Fox, E Pollina, M Zuckerman, S Chaudhry, and A Greenough
Prospective study of healthcare utilisation and respiratory morbidity due to RSV infection in prematurely born infants
Thorax, December 1, 2005; 60(12): 1039 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. J. Braciale
Respiratory Syncytial Virus and T Cells: Interplay between the Virus and the Host Adaptive Immune System
Proceedings of the ATS, August 1, 2005; 2(2): 141 - 146.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. A. Tripp, C. Oshansky, and R. Alvarez
Cytokines and Respiratory Syncytial Virus Infection
Proceedings of the ATS, August 1, 2005; 2(2): 147 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
F. D. Martinez
Heterogeneity of the Association between Lower Respiratory Illness in Infancy and Subsequent Asthma
Proceedings of the ATS, August 1, 2005; 2(2): 157 - 161.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Dakhama, J.-W. Park, C. Taube, A. Joetham, A. Balhorn, N. Miyahara, K. Takeda, and E. W. Gelfand
The Enhancement or Prevention of Airway Hyperresponsiveness during Reinfection with Respiratory Syncytial Virus Is Critically Dependent on the Age at First Infection and IL-13 Production
J. Immunol., August 1, 2005; 175(3): 1876 - 1883.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
K Yasui, N Kobayashi, T Yamazaki, K Koike, K Fukushima, S Taniuchi, and Y Kobayashi
Neutrophilic inflammation in childhood bronchial asthma
Thorax, August 1, 2005; 60(8): 704 - 705.
[Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
N D Embleton, C Harkensee, and M C Mckean
Palivizumab for preterm infants. Is it worth it?
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2005; 90(4): F286 - f289.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. R. Johnson, S. E. Mertz, N. Gitiban, S. Hammond, R. LeGallo, R. K. Durbin, and J. E. Durbin
Role for Innate IFNs in Determining Respiratory Syncytial Virus Immunopathology
J. Immunol., June 1, 2005; 174(11): 7234 - 7241.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
N. K. Leidy, M. K. Margolis, J. P. Marcin, J. A. Flynn, L. R. Frankel, S. Johnson, D. Langkamp, and E. A. F. Simoes
The Impact of Severe Respiratory Syncytial Virus on the Child, Caregiver, and Family During Hospitalization and Recovery
Pediatrics, June 1, 2005; 115(6): 1536 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Dakhama, J.-W. Park, C. Taube, M. El Gazzar, T. Kodama, N. Miyahara, K. Takeda, A. Kanehiro, A. Balhorn, A. Joetham, et al.
Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection
Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L761 - L770.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Oumouna, J. W. Mapletoft, B. C. Karvonen, L. A. Babiuk, and S. van Drunen Littel-van den Hurk
Formulation with CpG Oligodeoxynucleotides Prevents Induction of Pulmonary Immunopathology following Priming with Formalin-Inactivated or Commercial Killed Bovine Respiratory Syncytial Virus Vaccine
J. Virol., February 15, 2005; 79(4): 2024 - 2032.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Tayyari, T. C. Sutton, H. E. Manson, and R. G. Hegele
CpG-oligodeoxynucleotides inhibit RSV-enhanced allergic sensitisation in guinea pigs
Eur. Respir. J., February 1, 2005; 25(2): 295 - 302.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
R. J. Homer and J. A. Elias
Airway Remodeling in Asthma: Therapeutic Implications of Mechanisms
Physiology, February 1, 2005; 20(1): 28 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. Sigurs, P. M. Gustafsson, R. Bjarnason, F. Lundberg, S. Schmidt, F. Sigurbergsson, and B. Kjellman
Severe Respiratory Syncytial Virus Bronchiolitis in Infancy and Asthma and Allergy at Age 13
Am. J. Respir. Crit. Care Med., January 15, 2005; 171(2): 137 - 141.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. P. Bradley, L. B. Bacharier, J. Bonfiglio, K. B. Schechtman, R. Strunk, G. Storch, and M. Castro
Severity of Respiratory Syncytial Virus Bronchiolitis Is Affected by Cigarette Smoke Exposure and Atopy
Pediatrics, January 1, 2005; 115(1): e7 - e14.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
S. Wegner, J. J. Vann, G. Liu, P. Byrns, C. Cypra, W. Campbell, and A. Stiles
Direct Cost Analyses of Palivizumab Treatment in a Cohort of At-Risk Children: Evidence From the North Carolina Medicaid Program
Pediatrics, December 1, 2004; 114(6): 1612 - 1619.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Dakhama, J.-W. Park, C. Taube, K. Chayama, A. Balhorn, A. Joetham, X.-D. Wei, R.-H. Fan, C. Swasey, N. Miyahara, et al.
The Role of Virus-specific Immunoglobulin E in Airway Hyperresponsiveness
Am. J. Respir. Crit. Care Med., November 1, 2004; 170(9): 952 - 959.
[Abstract] [Full Text] [PDF]

Home page
 J. Epidemiol. Community HealthHome page
C. Cohet, S. Cheng, C. MacDonald, M. Baker, S. Foliaki, N. Huntington, J. Douwes, and N. Pearce
Infections, medication use, and the prevalence of symptoms of asthma, rhinitis, and eczema in childhood
J Epidemiol Community Health, October 1, 2004; 58(10): 852 - 857.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-Z. Wang, Y.-X. Bao, C. L. Rosenberger, Y. Tesfaigzi, J. M. Stark, and K. S. Harrod
IL-12p40 and IL-18 Modulate Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection
J. Immunol., September 15, 2004; 173(6): 4040 - 4049.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
J. Heidema, G. J. de Bree, P. M. A. de Graaff, W. W. C. van Maren, P. Hoogerhout, T. A. Out, J. L. L. Kimpen, and G. M. van Bleek
Human CD8+ T cell responses against five newly identified respiratory syncytial virus-derived epitopes
J. Gen. Virol., August 1, 2004; 85(8): 2365 - 2374.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A Greenough, J Alexander, S Burgess, J Bytham, P A J Chetcuti, J Hagan, W Lenney, S Melville, N J Shaw, J Boorman, et al.
Health care utilisation of prematurely born, preschool children related to hospitalisation for RSV infection
Arch. Dis. Child., July 1, 2004; 89(7): 673 - 678.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
L Bont, M Steijn, W M C van Aalderen, F Brus, J M Th Draaisma, R A A M Van Diemen-Steenvoorde, M Pekelharing-Berghuis, and J L L Kimpen
Seasonality of long term wheezing following respiratory syncytial virus lower respiratory tract infection
Thorax, June 1, 2004; 59(6): 512 - 516.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. Mejias, S. Chavez-Bueno, A. M. Rios, J. Saavedra-Lozano, M. Fonseca Aten, J. Hatfield, P. Kapur, A. M. Gomez, H. S. Jafri, and O. Ramilo
Anti-Respiratory Syncytial Virus (RSV) Neutralizing Antibody Decreases Lung Inflammation, Airway Obstruction, and Airway Hyperresponsiveness in a Murine RSV Model
Antimicrob. Agents Chemother., May 1, 2004; 48(5): 1811 - 1822.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
L. A. Rosenthal, L. D. Mikus, A. Tuffaha, A. G. Mosser, R. L. Sorkness, and R. F. Lemanske Jr.
Attenuated Innate Mechanisms of Interferon-{gamma} Production in Rats Susceptible to Postviral Airway Dysfunction
Am. J. Respir. Cell Mol. Biol., May 1, 2004; 30(5): 702 - 709.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Schwarze, D. R. O'Donnell, A. Rohwedder, and P. J. M. Openshaw
Latency and Persistence of Respiratory Syncytial Virus Despite T Cell Immunity
Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 801 - 805.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. L. Sorkness and A. Tuffaha
Contribution of airway closure to chronic postbronchiolitis airway dysfunction in rats
J Appl Physiol, March 1, 2004; 96(3): 904 - 910.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. Kondo, H. Matsuse, I. Machida, T. Kawano, S. Saeki, S. Tomari, Y. Obase, C. Fukushima, and S. Kohno
Regulation of Mite Allergen-pulsed Murine Dendritic Cells by Respiratory Syncytial Virus
Am. J. Respir. Crit. Care Med., February 15, 2004; 169(4): 494 - 498.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. F. Lemanske Jr.
Does Respiratory Syncytial Viral-induced Bronchiolitis Result from Helper T Cell Type 1/Type 2 Cytokine Imbalance?
Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): 625 - 627.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. P. Legg, I. R. Hussain, J. A. Warner, S. L. Johnston, and J. O. Warner
Type 1 and Type 2 Cytokine Imbalance in Acute Respiratory Syncytial Virus Bronchiolitis
Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): 633 - 639.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Ichinohe, I.R. Hussain, and S.L. Johnston
Cytokine production of RSV/PHA-stimulated tonsillar mononuclear cells: influences of age and atopy
Eur. Respir. J., August 1, 2003; 22(2): 317 - 322.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. J. Singleton, G. J. Redding, T. C. Lewis, P. Martinez, L. Bulkow, B. Morray, H. Peters, J. Gove, C. Jones, D. Stamey, et al.
Sequelae of Severe Respiratory Syncytial Virus Infection in Infancy and Early Childhood Among Alaska Native Children
Pediatrics, August 1, 2003; 112(2): 285 - 290.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
G. Rachelefsky
Treating Exacerbations of Asthma in Children: The Role of Systemic Corticosteroids
Pediatrics, August 1, 2003; 112(2): 382 - 397.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-Z. Wang, C. L. Rosenberger, Y.-X. Bao, J. M. Stark, and K. S. Harrod
Clara Cell Secretory Protein Modulates Lung Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection
J. Immunol., July 15, 2003; 171(2): 1051 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
F Nja, W Nystad, O Hetlevik, K C Lodrup Carlsen, and K-H Carlsen
Airway infections in infancy and the presence of allergy and asthma in school age children
Arch. Dis. Child., July 1, 2003; 88(7): 566 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
P. M. Kaan and R. G. Hegele
Interaction between Respiratory Syncytial Virus and Particulate Matter in Guinea Pig Alveolar Macrophages
Am. J. Respir. Cell Mol. Biol., June 1, 2003; 28(6): 697 - 704.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Wohlleben, J. Muller, U. Tatsch, C. Hambrecht, U. Herz, H. Renz, E. Schmitt, H. Moll, and K. J. Erb
Influenza A Virus Infection Inhibits the Efficient Recruitment of Th2 Cells into the Airways and the Development of Airway Eosinophilia
J. Immunol., May 1, 2003; 170(9): 4601 - 4611.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
V. R. G. Bachrach, E. Schwarz, and L. R. Bachrach
Breastfeeding and the Risk of Hospitalization for Respiratory Disease in Infancy: A Meta-analysis
Arch Pediatr Adolesc Med, March 1, 2003; 157(3): 237 - 243.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. F. Lemanske Jr.
Is Asthma an Infectious Disease?: Thomas A. Neff Lecture
Chest, March 1, 2003; 123 (2009): 385S - 390S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Bisgaard
A Randomized Trial of Montelukast in Respiratory Syncytial Virus Postbronchiolitis
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 379 - 383.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
P.G. Holt and P. D. Sly
Interactions between RSV Infection, Asthma, and Atopy: Unraveling the Complexities
J. Exp. Med., November 18, 2002; 196(10): 1271 - 1275.
[Full Text] [PDF]

Home page
 JEMHome page
F. J. Culley, J. Pollott, and P. J.M. Openshaw
Age at First Viral Infection Determines the Pattern of T Cell-mediated Disease during Reinfection in Adulthood
J. Exp. Med., November 18, 2002; 196(10): 1381 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
U. Schauer, S. Hoffjan, J. Bittscheidt, A. Kochling, S. Hemmis, S. Bongartz, and V. Stephan
RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life
Eur. Respir. J., November 1, 2002; 20(5): 1277 - 1283.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
S W Turner, S Young, L I Landau, and P N Le Souef
Reduced lung function both before bronchiolitis and at 11 years
Arch. Dis. Child., November 1, 2002; 87(5): 417 - 420.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G. Piedimonte and E.A.F. Simoes
Respiratory syncytial virus and subsequent asthma: one step closer to unravelling the Gordian knot?
Eur. Respir. J., September 1, 2002; 20(3): 515 - 517.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Pala, R. Bjarnason, F. Sigurbergsson, C. Metcalfe, N. Sigurs, and P.J.M. Openshaw
Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy
Eur. Respir. J., August 1, 2002; 20(2): 376 - 382.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Calvani Jr, C. Alessandri, and E. Bonci
Fever episodes in early life and the development of atopy in children with asthma
Eur. Respir. J., August 1, 2002; 20(2): 391 - 396.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W.H. Oddy, N.H. de Klerk, P.D. Sly, and P.G. Holt
The effects of respiratory infections, atopy, and breastfeeding on childhood asthma
Eur. Respir. J., May 1, 2002; 19(5): 899 - 905.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Schwarze and E.W. Gelfand
Respiratory viral infections as promoters of allergic sensitization and asthma in animal models
Eur. Respir. J., February 1, 2002; 19(2): 341 - 349.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. W. Thomas, M. M. Monick, J. M. Staber, T. Yarovinsky, A. B. Carter, and G. W. Hunninghake
Respiratory Syncytial Virus Inhibits Apoptosis and Induces NF-kappa B Activity through a Phosphatidylinositol 3-Kinase-dependent Pathway
J. Biol. Chem., January 4, 2002; 277(1): 492 - 501.
[Abstract] [Full Text]

Home page
 Eur Respir JHome page
G. Wennergren and S. Kristjansson
Relationship between respiratory syncytial virus bronchiolitis and future obstructive airway diseases
Eur. Respir. J., December 1, 2001; 18(6): 1044 - 1058.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A Greenough, S Cox, J Alexander, W Lenney, F Turnbull, S Burgess, P A J Chetcuti, N J Shaw, A Woods, J Boorman, et al.
Health care utilisation of infants with chronic lung disease, related to hospitalisation for RSV infection
Arch. Dis. Child., December 1, 2001; 85(6): 463 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K-;H. Carlsen and P.J. Sterk
Infection: friend or foe to the development of asthma?
Eur. Respir. J., November 1, 2001; 18(5): 744 - 747.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
E. von Mutius
Infection: friend or foe in the development of atopy and asthma? The epidemiological evidence
Eur. Respir. J., November 1, 2001; 18(5): 872 - 881.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2000
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1581 - 1594.
[Full Text] [PDF]

Home page
 BMJHome page
V. Angelakou, M. Bitsori, E. Galanakis, A.-L. Ponsonby, and A. Kemp
Asthma and early childhood infectious disease
BMJ, July 21, 2001; 323(7305): 164 - 164.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. A. F. SIMOES
Treatment and Prevention of Respiratory Syncytial Virus Lower Respiratory Tract Infection . Long-Term Effects on Respiratory Outcomes
Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): S14 - 17.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. PIEDIMONTE
Neural Mechanisms of Respiratory Syncytial Virus-induced Inflammation and Prevention of Respiratory Syncytial Virus Sequelae
Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): S18 - 21.
[Full Text] [PDF]

Home page
 BMJHome page
S. L Johnston and P. J M Openshaw
The protective effect of childhood infections
BMJ, February 17, 2001; 322(7283): 376 - 377.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society 		  Mastering Teaching Skills in Pulm & Crit Care Med