help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by  KLOOT, T. E.V. d.
Right arrow Articles by NAHUM, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by  KLOOT, T. E.V. d.
Right arrow Articles by NAHUM, A.

Am. J. Respir. Crit. Care Med., Volume 161, Number 5, May 2000, 1485-1494

Recruitment Maneuvers in Three Experimental Models of Acute Lung Injury
Effect on Lung Volume and Gas Exchange

THOMAS E.VAN der  KLOOT, LLUIS BLANCH, A. MELYNNE YOUNGBLOOD, CRAIG WEINERT, ALEX B. ADAMS, JOHN J. MARINI, ROBERT S. SHAPIRO, and AVI NAHUM

Department of Pulmonary and Critical Care Medicine, University of Minnesota, Regions Hospital, St. Paul, Minnesota; and Servei de Medicina Intensiva, Hospital de Sabadell, Corporacio Hospitalaria del Parc Tauli, Sabadell, Spain

Recruitment maneuvers (RM), consisting of sustained inflations at high airway pressures, have been advocated as an adjunct to mechanical ventilation in acute respiratory distress syndrome (ARDS). We studied the effect of baseline ventilatory strategy and RM on end-expiratory lung volume (EELV) and oxygenation in 18 dogs, using three models of acute lung injury (ALI; n = 6 in each group): saline lavage (LAV), oleic acid injury (OAI), and intratracheal instillation of Escherichia coli (pneumonia; PNM). All three models exhibited similar degrees of lung injury. The PNM model was less responsive to positive end-expiratory pressure (PEEP) than was the LAV or OAI model. Only the LAV model showed an oxygenation response to increasing tidal volume (VT). After RM, there were transient increases in PaO2 and EELV when ventilating with PEEP = 10 cm H2O. At PEEP = 20 cm H2O the lungs were probably fully recruited, since the plateau airway pressures were relatively high (approx  45 cm H2O) and the oxygenation was similar to preinjury values, thus making the system unresponsive to RM. Sustained improvement in oxygenation after RM was seen in the LAV model when ventilating with PEEP = 10 cm H2O and VT = 15 ml/kg. Changes in EELV correlated with changes in PaO2 only in the OAI model with PEEP = 10 cm H2O. We conclude that responses to PEEP, VT, and RM differ among these models of ALI. RM may have a role in some patients with ARDS who are ventilated with low PEEP and low VT.




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Iglesias, P. Jungebluth, C. Petit, M. P. Matute, I. Rovira, E. Martinez, M. Catalan, J. Ramirez, and P. Macchiarini
Extracorporeal lung membrane provides better lung protection than conventional treatment for severe postpneumonectomy noncardiogenic acute respiratory distress syndrome.
J. Thorac. Cardiovasc. Surg., June 1, 2008; 135(6): 1362 - 1371.e4.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. M. Otto, K. Markstaller, O. Kajikawa, J. Karmrodt, R. S. Syring, B. Pfeiffer, V. P. Good, C. W. Frevert, and J. E. Baumgardner
Spatial and temporal heterogeneity of ventilator-associated lung injury after surfactant depletion
J Appl Physiol, May 1, 2008; 104(5): 1485 - 1494.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Musch, G. Bellani, M. F. Vidal Melo, R. S. Harris, T. Winkler, T. Schroeder, and J. G. Venegas
Relation between Shunt, Aeration, and Perfusion in Experimental Acute Lung Injury
Am. J. Respir. Crit. Care Med., February 1, 2008; 177(3): 292 - 300.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. B. Allen, T. Leclair, M. Cloutier, J. Thompson-Figueroa, and J. H. T. Bates
The response to recruitment worsens with progression of lung injury and fibrin accumulation in a mouse model of acid aspiration
Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1580 - L1589.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. S. Syring, C. M. Otto, R. E. Spivack, K. Markstaller, and J. E. Baumgardner
Maintenance of end-expiratory recruitment with increased respiratory rate after saline-lavage lung injury
J Appl Physiol, January 1, 2007; 102(1): 331 - 339.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. Karmrodt, C. Bletz, S. Yuan, M. David, C.-P. Heussel, and K. Markstaller
Quantification of atelectatic lung volumes in two different porcine models of ARDS
Br. J. Anaesth., December 1, 2006; 97(6): 883 - 895.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
J. Brederlau, R. Muellenbach, M. Kredel, U. Schwemmer, M. Anetseder, C. Greim, and N. Roewer
The contribution of arterio-venous extracorporeal lung assist to gas exchange in a porcine model of lavage-induced acute lung injury
Perfusion, September 1, 2006; 21(5): 277 - 284.
[Abstract] [PDF]

Home page
 ChestHome page
T. Luecke, J. P. Meinhardt, P. Herrmann, A. Weiss, M. Quintel, and P. Pelosi
Oleic Acid vs Saline Solution Lung Lavage-Induced Acute Lung Injury: Effects on Lung Morphology, Pressure-Volume Relationships, and Response to Positive End-Expiratory Pressure.
Chest, August 1, 2006; 130(2): 392 - 401.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Sindelar, A. Jonzon, A. Schulze, and G. Sedin
Surfactant replacement partially restores the activity of pulmonary stretch receptors in surfactant-depleted cats
J Appl Physiol, February 1, 2006; 100(2): 594 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
G. Mols, H.-J. Priebe, and J. Guttmann
Alveolar recruitment in acute lung injury
Br. J. Anaesth., February 1, 2006; 96(2): 156 - 166.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. L. S. Menezes, P. T. Bozza, H. C. C. Faria Neto, A. P. Laranjeira, E. M. Negri, V. L. Capelozzi, W. A. Zin, and P. R. M. Rocco
Pulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses
J Appl Physiol, May 1, 2005; 98(5): 1777 - 1783.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
E. A. J. Hoste, C. D. V. K. Roosens, S. Bracke, J. M. A. Decruyenaere, D. D. Benoit, K. H. D. K. Vandewoude, and F. A. Colardyn
Acute Effects of Upright Position on Gas Exchange in Patients With Acute Respiratory Distress Syndrome
J Intensive Care Med, January 1, 2005; 20(1): 43 - 49.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
L. L. Farias, D. S. Faffe, D. G. Xisto, M. C. E. Santana, R. Lassance, L. F. M. Prota, M. B. Amato, M. M. Morales, W. A. Zin, and P. R. M. Rocco
Positive end-expiratory pressure prevents lung mechanical stress caused by recruitment/derecruitment
J Appl Physiol, January 1, 2005; 98(1): 53 - 61.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. M. Albaiceta, F. Taboada, D. Parra, L. H. Luyando, J. Calvo, R. Menendez, and J. Otero
Tomographic Study of the Inflection Points of the Pressure-Volume Curve in Acute Lung Injury
Am. J. Respir. Crit. Care Med., November 15, 2004; 170(10): 1066 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. M. Downie, A. J. Nam, and B. A. Simon
Pressure-Volume Curve Does Not Predict Steady-State Lung Volume in Canine Lavage Lung Injury
Am. J. Respir. Crit. Care Med., April 15, 2004; 169(8): 957 - 962.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. Rylander, M. Hogman, G. Perchiazzi, A. Magnusson, and G. Hedenstierna
Functional Residual Capacity and Respiratory Mechanics as Indicators of Aeration and Collapse in Experimental Lung Injury
Anesth. Analg., March 1, 2004; 98(3): 782 - 789.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Allen and J. H. T. Bates
Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury
J Appl Physiol, January 1, 2004; 96(1): 293 - 300.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J-J. Rouby, Q. Lu, and S. Vieira
Pressure/volume curves and lung computed tomography in acute respiratory distress syndrome
Eur. Respir. J., August 1, 2003; 22(42_suppl): 27s - 36s.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Moran, E. Zavala, R. Fernandez, L. Blanch, and J. Mancebo
Recruitment manoeuvres in acute lung injury/acute respiratory distress syndrome
Eur. Respir. J., August 1, 2003; 22(42_suppl): 37s - 42s.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Pelosi, D. D'Onofrio, D. Chiumello, S. Paolo, G. Chiara, V.L. Capelozzi, C.S.V. Barbas, M. Chiaranda, and L. Gattinoni
Pulmonary and extrapulmonary acute respiratory distress syndrome are different
Eur. Respir. J., August 1, 2003; 22(42_suppl): 48s - 56s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Sottiaux, A. Villagra, J. L. Aguilar, and L. Blanch
Recruitment maneuvers in ARDS
Am. J. Respir. Crit. Care Med., June 1, 2003; 167(11): 1575 - 1575.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Pelosi, N. Bottino, D. Chiumello, P. Caironi, M. Panigada, C. Gamberoni, G. Colombo, L. M. Bigatello, and L. Gattinoni
Sigh in Supine and Prone Position during Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 521 - 527.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. E. Baumgardner, K. Markstaller, B. Pfeiffer, M. Doebrich, and C. M. Otto
Effects of Respiratory Rate, Plateau Pressure, and Positive End-Expiratory Pressure on PaO2 Oscillations after Saline Lavage
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1556 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
J. Paratz, J. Lipman, and M. McAuliffe
Effect of Manual Hyperinflation on Hemodynamics, Gas Exchange, and Respiratory Mechanics in Ventilated Patients
J Intensive Care Med, November 1, 2002; 17(6): 317 - 324.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Allen, L. K. A. Lundblad, P. Parsons, and J. H. T. Bates
Transient mechanical benefits of a deep inflation in the injured mouse lung
J Appl Physiol, November 1, 2002; 93(5): 1709 - 1715.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. J. ROUBY, Q. LU, and I. GOLDSTEIN
Selecting the Right Level of Positive End-Expiratory Pressure in Patients with Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., April 15, 2002; 165(8): 1182 - 1186.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. VILLAGRA, A. OCHAGAVIA, S. VATUA, G. MURIAS, M. DEL MAR FERNANDEZ, J. L. AGUILAR, R. FERNANDEZ, and L. BLANCH
Recruitment Maneuvers during Lung Protective Ventilation in Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 165 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Critical Care Medicine in AJRCCM 2000
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1347 - 1361.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. TAKEUCHI, K. A. SEDEEK, G. P. P. SCHETTINO, K. SUCHODOLSKI, and R. M. KACMAREK
Peak Pressure During Volume History and Pressure-Volume Curve Measurement Affects Analysis
Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1225 - 1230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. BLANCH, T. E. VAN der KLOOT, A. M. YOUNGBLOOD, G. MURIAS, A. NAVEIRA, A. B. ADAMS, P. V. ROMERO, and A. NAHUM
Application of Tracheal Gas Insufflation to Acute Unilateral Lung Injury in an Experimental Model
Am. J. Respir. Crit. Care Med., August 15, 2001; 164(4): 642 - 647.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. J. Marini
Ventilator-induced Airway Dysfunction?
Am. J. Respir. Crit. Care Med., March 15, 2001; 163(4): 806 - 807.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society