help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by NEWMAN, V.
Right arrow Articles by DOBBS, L. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NEWMAN, V.
Right arrow Articles by DOBBS, L. G.

Am. J. Respir. Crit. Care Med., Volume 161, Number 3, March 2000, 990-995

A Novel Alveolar Type I Cell-Specific Biochemical Marker of Human Acute Lung Injury

VALERIE NEWMAN, ROBERT F. GONZALEZ, MICHAEL A. MATTHAY, and LELAND G. DOBBS

Cardiovascular Research Institute, Departments of Pediatrics and Medicine, University of California, San Francisco, California

Currently there is no recognized biochemical or molecular marker for human parenchymal lung injury analogous to markers for acute myocardial injury. Injury to the alveolar epithelial barrier is of central importance in the pathogenesis of and recovery from acute lung injury. In animal models, an alveolar type I cell-specific protein, RTI40, has been shown to be an accurate marker of alveolar epithelial damage. We now report that HTI56, a novel apical plasma membrane protein specific to the human type I cell, is a biochemical marker for lung injury. Using a sensitive, quantitative, light-based ELISA, we measured HTI56 in pulmonary edema fluid from 15 patients with a clinical diagnosis of acute lung injury and 12 control patients with hydrostatic (cardiogenic) pulmonary edema. HTI56 was also measured in plasma from these two groups and from 11 normal volunteers. The amount of HTI56 was 4.3-fold higher (p < 0.0001) in alveolar edema fluid and 1.4-fold higher (p < 0.05) in plasma from the patients with acute lung injury, compared with patients with hydrostatic pulmonary edema. To our knowledge, this study is the first to utilize a specific marker of alveolar epithelial damage in human disease and demonstrates the feasibility of using a blood test to detect lung parenchymal damage. Newman V, Gonzalez RF, Matthay MA, Dobbs LG. A novel alveolar type I cell-specific biochemical marker of human acute lung injury.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Uchida, M. Shirasawa, L. B. Ware, K. Kojima, Y. Hata, K. Makita, G. Mednick, Z. A. Matthay, and M. A. Matthay
Receptor for Advanced Glycation End-Products Is a Marker of Type I Cell Injury in Acute Lung Injury
Am. J. Respir. Crit. Care Med., May 1, 2006; 173(9): 1008 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. P. Mendez, S. B. Morris, S. Wilcoxen, E. Greeson, B. Moore, and R. Paine III
Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L962 - L970.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Chen, Z. Chen, N. R. Chintagari, M. Bhaskaran, N. Jin, T. Narasaraju, and L. Liu
Alveolar type I cells protect rat lung epithelium from oxidative injury
J. Physiol., May 1, 2006; 572(3): 625 - 638.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. A. Matthay, L. Robriquet, and X. Fang
Alveolar Epithelium: Role in Lung Fluid Balance and Acute Lung Injury
Proceedings of the ATS, October 1, 2005; 2(3): 206 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M.C. McElroy and M. Kasper
The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair
Eur. Respir. J., October 1, 2004; 24(4): 664 - 673.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
C. A. Piantadosi and D. A. Schwartz
The Acute Respiratory Distress Syndrome
Ann Intern Med, September 21, 2004; 141(6): 460 - 470.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Hirsch, K. C. Hansen, A. L. Burlingame, and M. A. Matthay
Proteomics: current techniques and potential applications to lung disease
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L1 - L23.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. P. Bowler, B. Duda, E. D. Chan, J. J. Enghild, L. B. Ware, M. A. Matthay, and M. W. Duncan
Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1095 - L1104.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. C. Parker and M. I. Townsley
Evaluation of lung injury in rats and mice
Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L231 - L246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. Lesur, C. Hermans, J.-F. Chalifour, J. Picotte, B. Levy, A. Bernard, and D. Lane
Mechanical ventilation-induced pneumoprotein CC-16 vascular transfer in rats: effect of KGF pretreatment
Am J Physiol Lung Cell Mol Physiol, February 1, 2003; 284(2): L410 - L419.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. A. Matthay
Alveolar Fluid Clearance in Patients With ARDS: Does It Make a Difference?
Chest, December 1, 2002; 122(6_suppl): 340S - 343S.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Sartori and M.A. Matthay
Alveolar epithelial fluid transport in acute lung injury: new insights
Eur. Respir. J., November 1, 2002; 20(5): 1299 - 1313.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. A. Matthay, H. G. Folkesson, and C. Clerici
Lung Epithelial Fluid Transport and the Resolution of Pulmonary Edema
Physiol Rev, July 1, 2002; 82(3): 569 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. A. FRANK, J. A. GUTIERREZ, K. D. JONES, L. ALLEN, L. DOBBS, and M. A. MATTHAY
Low Tidal Volume Reduces Epithelial and Endothelial Injury in Acid-injured Rat Lungs
Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 242 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Critical Care Medicine in AJRCCM 2000
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1347 - 1361.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. D. CRANDALL and M. A. MATTHAY
Alveolar Epithelial Transport . Basic Science to Clinical Medicine
Am. J. Respir. Crit. Care Med., March 15, 2001; 163(4): 1021 - 1029.
[Full Text]

Home page
 NEJMHome page
L. B. Ware and M. A. Matthay
The Acute Respiratory Distress Syndrome
N. Engl. J. Med., May 4, 2000; 342(18): 1334 - 1349.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society 		  ATS 2008 State of the Art Course