Am. J. Respir. Crit. Care Med., Volume 161, Number 3, March 2000, 819-826

Compensation for Increase in Respiratory Workload during Mechanical Ventilation
Pressure-Support versus Proportional-Assist Ventilation

SALVATORE GRASSO, FILOMENA PUNTILLO, LUCIANA MASCIA, GIOVANNI ANCONA, TOMMASO FIORE, FRANCESCO BRUNO, ARTHUR S. SLUTSKY, and V. MARCO RANIERI

Dipartimento di Emergenza e Trapianti d'Organo, sezione di Anestesiologia Rianimazione, Ospedale Policlinico, Università di Bari, and Ospedale DiVenere, Bari, Italy; and Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

Variation in respiratory impedance may occur in mechanically ventilated patients. During pressure-targeted ventilatory support, this may lead to patient-ventilator asynchrony. We assessed the hypothesis that during pressure-support ventilation (PSV), preservation of minute ventilation ( E) consequent to added mechanical loads would result in an increase in respiratory rate (RR) due to the large reduction in tidal volume (VT). WITH proportional-assist ventilation (PAV), preservation of E would occur through the preservation of VT, with a smaller effect on RR. We anticipated that this compensatory strategy would result in greater patient comfort and a reduce work of breathing. An increase in respiratory impedance was obtained by chest and abdominal binding in 10 patients during weaning from mechanical ventilation. E remained constant in both ventilatory modes after chest and abdominal compression. During PSV, this maintenance of VE was obtained through a 58 ± 3% increase in RR that compensated for a 29 ± 2% reduction in VT. The magnitudes of the reduction in VT (10 ± 3%) and of the increase in RR (14 ± 2%) were smaller (p < 0.001) during PAV. During both PSV and PAV, chest and abdominal compression caused increases in both the pressure-time product (PTP) of the diaphragm per minute (142.9 ± 26.9 cm H₂O · s/min, PSV, and 117.6 ± 16.4 cm H₂O · s/min, PAV) and per liter (13.4 ± 2.5 cm H₂O · s/L, PSV, and 9.6 ± 0.7 cm H₂O · s/L, PAV). These increments were greater (p < 0.001) during PSV than during PAV. The capability of keeping VT and E constant through increases in inspiratory effort after increases in mechanical loads is relatively preserved only during PAV. The ventilatory response to an added respiratory load during PSV required greater muscle effort than during PAV. Grasso S, Puntillo F, Mascia L, Ancona G, Fiore T, Bruno F, Slutsky AS, Ranieri VM. Compensation for increase in respiratory workload during mechanical ventilation: pressure-support versus proportional-assist ventilation.

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