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Am. J. Respir. Crit. Care Med., Volume 161, Number 3, March 2000, 718-722

Influenza Virus Inhibits Lysozyme Secretion by Sputum Neutrophils in Subjects with Chronic Bronchial Sepsis

GERALD PANG, ROBERT CLANCY, MA CONG, MARIA ORTEGA, REN ZHIGANG, and GLEN REEVES

Faculty of Medicine and Health Sciences, University of Newcastle; and Hunter Immunology Unit, Royal Newcastle Hospital, Newcastle, Australia

Neutrophils are central to the control of infection within the bronchial mucosa. To determine whether the link between bacterial and viral infection in the respiratory tract can be partly explained by acute reduction of neutrophil function, we examined the influence of influenza virus on lysozyme secretion by sputum neutrophils obtained from patients with bronchiectasis. Sputum neutrophils infected with influenza A virus had a significantly reduced capacity to secrete lysozyme but not myeloperoxidase. Influenza virus A strains were more effective in inhibiting lysozyme secretion than were influenza B virus strains. Reduction of bactericidal activity was similarly reduced by different strains of influenza A virus, but an influenza virus B strain had no effect. Our results show that downregulation of sputum neutrophil function characterized by lysozyme secretion and bactericidal activity could contribute to reduction in the capacity to control bacterial colonization in the respiratory tract following influenza virus infection. Pang G, Clancy R, Cong M, Ortega M, Zhigang R, Reeves G. Influenza virus inhibits lysozyme secretion by sputum neutrophils in subjects with chronic bronchial sepsis.




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Copyright © 2000 American Thoracic Society 		  ATS 2008 State of the Art Course