help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HUNT, J. F.
Right arrow Articles by GASTON, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HUNT, J. F.
Right arrow Articles by GASTON, B.

Am. J. Respir. Crit. Care Med., Volume 161, Number 3, March 2000, 694-699

Endogenous Airway Acidification
Implications for Asthma Pathophysiology

JOHN F. HUNT, KEZHONG FANG, RAJESH MALIK, ASHLEY SNYDER, NEIL MALHOTRA, THOMAS A. E. PLATTS-MILLS, and BENJAMIN GASTON

Divisions of Pediatric Respiratory Medicine, Pediatric Hematology/Oncology, and Allergy, Asthma and Immunology, University of Virginia Health System, Charlottesville, Virginia

Airway concentrations of many reactive nitrogen and oxygen species are high in asthma. The stability and bioactivities of these species are pH-dependent; however, the pH of the airway during acute asthma has not previously been studied. As with gastric and urinary acidification, asthmatic airway acidification could be expected dramatically to alter the concentrations and bioactivities/cytotoxicities of endogenous nitrogen oxides. Here, we demonstrate that the pH of deaerated exhaled airway vapor condensate is over two log orders lower in patients with acute asthma (5.23 ± 0.21, n = 22) than in control subjects (7.65 ± 0.20, n = 19, p < 0.001) and normalizes with corticosteroid therapy. Values are highly reproducible, unaffected by salivary or therapeutic artifact, and identical to samples taken directly from the lower airway. Further, at these low pH values, the endogenous airway compound, nitrite, is converted to nitric oxide (NO) in quantities sufficient largely to account for the concentrations of NO in asthmatic expired air, and eosinophils undergo accelerated necrosis. We speculate that airway pH may be an important determinant of expired NO concentration and airway inflammation, and suggest that regulation of airway pH has a previously unsuspected role in asthma pathophysiology. Hunt JF, Fang K, Malik R, Snyder A, Malhotra N, Platts-Mills TAE, Gaston B. Endogenous airway acidification: implications for asthma pathophysiology.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
Y. Fukuoka, H.-Z. Xia, L. B. Sanchez-Munoz, A. L. Dellinger, L. Escribano, and L. B. Schwartz
Generation of Anaphylatoxins by Human {beta}-Tryptase from C3, C4, and C5
J. Immunol., May 1, 2008; 180(9): 6307 - 6316.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Kullmann, I. Barta, B. Antus, M. Valyon, and I. Horvath
Environmental temperature and relative humidity influence exhaled breath condensate pH
Eur. Respir. J., February 1, 2008; 31(2): 474 - 475.
[Full Text] [PDF]

Home page
 NEJMHome page
J. McCreanor, P. Cullinan, M. J. Nieuwenhuijsen, J. Stewart-Evans, E. Malliarou, L. Jarup, R. Harrington, M. Svartengren, I.-K. Han, P. Ohman-Strickland, et al.
Respiratory Effects of Exposure to Diesel Traffic in Persons with Asthma
N. Engl. J. Med., December 6, 2007; 357(23): 2348 - 2358.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Khodoun, C. Lewis, J.-Q. Yang, T. Orekov, C. Potter, T. Wynn, M. Mentink-Kane, G. K. Khurana Hershey, M. Wills-Karp, and F. D. Finkelman
Differences in Expression, Affinity, and Function of Soluble (s)IL-4R{alpha} and sIL-13R{alpha}2 Suggest Opposite Effects on Allergic Responses
J. Immunol., November 15, 2007; 179(10): 6429 - 6438.
[Abstract] [Full Text] [PDF]

Home page
 Therapeutic Advances in Respiratory DiseaseHome page
P. Montuschi
Review: Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications
Therapeutic Advances in Respiratory Disease, October 1, 2007; 1(1): 5 - 23.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
D. Martinez, M. Vermeulen, E. von Euw, J. Sabatte, J. Maggini, A. Ceballos, A. Trevani, K. Nahmod, G. Salamone, M. Barrio, et al.
Extracellular Acidosis Triggers the Maturation of Human Dendritic Cells and the Production of IL-12
J. Immunol., August 1, 2007; 179(3): 1950 - 1959.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Horvath
From the authors
Eur. Respir. J., July 1, 2007; 30(1): 187 - 187.
[Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
A. Schmid, Z. Sutto, M.-C. Nlend, G. Horvath, N. Schmid, J. Buck, L. R. Levin, G. E. Conner, N. Fregien, and M. Salathe
Soluble Adenylyl Cyclase Is Localized to Cilia and Contributes to Ciliary Beat Frequency Regulation via Production of cAMP
J. Gen. Physiol., July 1, 2007; 130(1): 99 - 109.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Kodric, A. N. Shah, L. M. Fabbri, and M. Confalonieri
An Investigation of Airway Acidification in Asthma Using Induced Sputum: A Study of Feasibility and Correlation
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 905 - 910.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Kullmann, I. Barta, Z. Lazar, B. Szili, E. Barat, M. Valyon, M. Kollai, and I. Horvath
Exhaled breath condensate pH standardised for CO2 partial pressure
Eur. Respir. J., March 1, 2007; 29(3): 496 - 501.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H.-W. Shin, D. A. Shelley, E. M. Henderson, A. Fitzpatrick, B. Gaston, and S. C. George
Airway nitric oxide release is reduced after PBS inhalation in asthma
J Appl Physiol, March 1, 2007; 102(3): 1028 - 1033.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. S. Jackson, A. Sandrini, C. Campbell, S. Chow, P. S. Thomas, and D. H. Yates
Comparison of Biomarkers in Exhaled Breath Condensate and Bronchoalveolar Lavage
Am. J. Respir. Crit. Care Med., February 1, 2007; 175(3): 222 - 227.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. Horvath, N. Schmid, M. A. Fragoso, A. Schmid, G. E. Conner, M. Salathe, and A. Wanner
Epithelial Organic Cation Transporters Ensure pH-Dependent Drug Absorption in the Airway
Am. J. Respir. Cell Mol. Biol., January 1, 2007; 36(1): 53 - 60.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
S. Carraro
Noninvasive markers of airway inflammation and redox biochemistry applied to asthma
Eur. Respir. Rev., December 1, 2006; 15(101): 202 - 203.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Su, Q. Li, K. Shrestha, E. Cormet-Boyaka, L. Chen, P. R. Smith, E. J. Sorscher, D. J. Benos, S. Matalon, and H.-L. Ji
Interregulation of Proton-gated Na+ Channel 3 and Cystic Fibrosis Transmembrane Conductance Regulator
J. Biol. Chem., December 1, 2006; 281(48): 36960 - 36968.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. C. Nicolaou, L. A. Lowe, C. S. Murray, A. Woodcock, A. Simpson, and A. Custovic
Exhaled Breath Condensate pH and Childhood Asthma: Unselected Birth Cohort Study
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 254 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
Z. L. Borrill, J. A. Smith, J. Naylor, A. A. Woodcock, and D. Singh
The effect of gas standardisation on exhaled breath condensate pH.
Eur. Respir. J., July 1, 2006; 28(1): 251 - 252.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Carraro, J. Doherty, K. Zaman, I. Gainov, R. Turner, J. Vaughan, J. F. Hunt, J. Marquez, and B. Gaston
S-nitrosothiols regulate cell-surface pH buffering by airway epithelial cells during the human immune response to rhinovirus
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L827 - L832.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Fukuoka and L. B. Schwartz
The B12 Anti-Tryptase Monoclonal Antibody Disrupts the Tetrameric Structure of Heparin-Stabilized beta-Tryptase to Form Monomers That Are Inactive at Neutral pH and Active at Acidic pH.
J. Immunol., March 1, 2006; 176(5): 3165 - 3172.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Hunt
Exhaled Breath Condensate pH: Reflecting Acidification of the Airway at All Levels
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 366 - 367.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. M. Effros, R. Casaburi, J. Su, M. Dunning, J. Torday, J. Biller, and R. Shaker
The Effects of Volatile Salivary Acids and Bases on Exhaled Breath Condensate pH
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 386 - 392.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. O. Paget-Brown, L. Ngamtrakulpanit, A. Smith, D. Bunyan, S. Hom, A. Nguyen, and J. F. Hunt
Normative Data for pH of Exhaled Breath Condensate.
Chest, February 1, 2006; 129(2): 426 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M.-G. Lee, B. J. Undem, C. Brown, and M. J. Carr
Effect of Nociceptin in Acid-evoked Cough and Airway Sensory Nerve Activation in Guinea Pigs
Am. J. Respir. Crit. Care Med., February 1, 2006; 173(3): 271 - 275.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Martinez, M. Vermeulen, A. Trevani, A. Ceballos, J. Sabatte, R. Gamberale, M. E. Alvarez, G. Salamone, T. Tanos, O. A. Coso, et al.
Extracellular Acidosis Induces Neutrophil Activation by a Mechanism Dependent on Activation of Phosphatidylinositol 3-Kinase/Akt and ERK Pathways
J. Immunol., January 15, 2006; 176(2): 1163 - 1171.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
ATS Workshop Proceedings: Exhaled Nitric Oxide and Nitric Oxide Oxidative Metabolism in Exhaled Breath Condensate.
Proceedings of the ATS, January 1, 2006; 3(2): 131 - 145.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. M. Effros, B. Peterson, R. Casaburi, J. Su, M. Dunning, J. Torday, J. Biller, and R. Shaker
Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects
J Appl Physiol, October 1, 2005; 99(4): 1286 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
O. Holz
Catching breath: monitoring airway inflammation using exhaled breath condensate
Eur. Respir. J., September 1, 2005; 26(3): 371 - 372.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Horvath, J. Hunt, P. J. Barnes, and On behalf of the ATS/ERS Task Force on Exhaled Bre
Exhaled breath condensate: methodological recommendations and unresolved questions
Eur. Respir. J., September 1, 2005; 26(3): 523 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G. MacGregor, S. Ellis, J. Andrews, M. Imrie, A. Innes, A. P. Greening, and S. Cunningham
Breath condensate ammonium is lower in children with chronic asthma
Eur. Respir. J., August 1, 2005; 26(2): 271 - 276.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. D'Angelo, M. Pecchiari, P. D. Valle, A. Koutsoukou, and J. Milic-Emili
Effects of mechanical ventilation at low lung volume on respiratory mechanics and nitric oxide exhalation in normal rabbits
J Appl Physiol, August 1, 2005; 99(2): 433 - 444.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. J. Lang, P. Dong, E. K. Hosszu, and I. R. Doyle
Effect of CO2 on LPS-induced cytokine responses in rat alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L96 - L103.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. L. Miller, P. Zhang, M. Smith, V. Beaulieu, T. G. Paunescu, D. Brown, S. Breton, and R. D. Nelson
V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice
Am J Physiol Cell Physiol, May 1, 2005; 288(5): C1134 - C1144.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. M. Prado, E. A. Leick-Maldonado, V. Arata, D. I. Kasahara, M. A. Martins, and I. F. L. C. Tiberio
Neurokinins and inflammatory cell iNOS expression in guinea pigs with chronic allergic airway inflammation
Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L741 - L748.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
H Marteus, D C Tornberg, E Weitzberg, U Schedin, and K Alving
Origin of nitrite and nitrate in nasal and exhaled breath condensate and relation to nitric oxide formation
Thorax, March 1, 2005; 60(3): 219 - 225.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
Z. Borrill, C. Starkey, J. Vestbo, and D. Singh
Reproducibility of exhaled breath condensate pH in chronic obstructive pulmonary disease
Eur. Respir. J., February 1, 2005; 25(2): 269 - 274.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. G. Radu, A. Nijagal, J. McLaughlin, L. Wang, and O. N. Witte
Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells
PNAS, February 1, 2005; 102(5): 1632 - 1637.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J F Hunt
Informative complexity of exhaled nitrogen oxide chemistry
Thorax, January 1, 2005; 60(1): 2 - 3.
[Full Text] [PDF]

Home page
 ThoraxHome page
J C Ojoo, S A Mulrennan, J A Kastelik, A H Morice, and A E Redington
Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis
Thorax, January 1, 2005; 60(1): 22 - 26.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
K Wells, J Vaughan, T N Pajewski, S Hom, L Ngamtrakulpanit, A Smith, A Nguyen, R Turner, and J Hunt
Exhaled breath condensate pH assays are not influenced by oral ammonia
Thorax, January 1, 2005; 60(1): 27 - 31.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. M. Effros, M. B. Dunning III, J. Biller, and R. Shaker
The promise and perils of exhaled breath condensates
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1073 - L1080.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. A. Kharitonov and P. J. Barnes
Effects of Corticosteroids on Noninvasive Biomarkers of Inflammation in Asthma and Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, November 1, 2004; 1(3): 191 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. Ziora, K. Kaluska, and J. Kozielski
An increase in exhaled nitric oxide is not associated with activity in pulmonary sarcoidosis
Eur. Respir. J., October 1, 2004; 24(4): 609 - 614.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Schwarzer, T. E. Machen, B. Illek, and H. Fischer
NADPH Oxidase-dependent Acid Production in Airway Epithelial Cells
J. Biol. Chem., August 27, 2004; 279(35): 36454 - 36461.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J B McCafferty, T A Bradshaw, S Tate, A P Greening, and J A Innes
Effects of breathing pattern and inspired air conditions on breath condensate volume, pH, nitrite, and protein concentrations
Thorax, August 1, 2004; 59(8): 694 - 698.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. R. Morris, M. Poljakovic, L. Lavrisha, L. Machado, F. A. Kuypers, and S. M. Morris Jr.
Decreased Arginine Bioavailability and Increased Serum Arginase Activity in Asthma
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 148 - 153.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Hjoberg, S. Shore, L. Kobzik, S. Okinaga, A. Hallock, J. Vallone, V. Subramaniam, G. T. De Sanctis, J. A. Elias, J. M. Drazen, et al.
Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness
J Appl Physiol, July 1, 2004; 97(1): 249 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. L. M. Ricciardolo, P. J. Sterk, B. Gaston, and G. Folkerts
Nitric Oxide in Health and Disease of the Respiratory System
Physiol Rev, July 1, 2004; 84(3): 731 - 765.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A Niimi, L T Nguyen, O Usmani, B Mann, and K F Chung
Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough
Thorax, July 1, 2004; 59(7): 608 - 612.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
Z. Zhu, T. Zheng, R. J. Homer, Y.-K. Kim, N. Y. Chen, L. Cohn, Q. Hamid, and J. A. Elias
Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
Science, June 11, 2004; 304(5677): 1678 - 1682.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R.M. Effros
Exhaled breath condensate pH
Eur. Respir. J., June 1, 2004; 23(6): 961 - 962.
[Full Text] [PDF]

Home page
 ChestHome page
G. E. Carpagnano, P. J. Barnes, J. Francis, N. Wilson, A. Bush, and S. A. Kharitonov
Breath Condensate pH in Children With Cystic Fibrosis and Asthma: A New Noninvasive Marker of Airway Inflammation?
Chest, June 1, 2004; 125(6): 2005 - 2010.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G Adamkiewicz, S Ebelt, M Syring, J Slater, F E Speizer, J Schwartz, H Suh, and D R Gold
Association between air pollution exposure and exhaled nitric oxide in an elderly population
Thorax, March 1, 2004; 59(3): 204 - 209.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Vermeulen, M. Giordano, A. S. Trevani, C. Sedlik, R. Gamberale, P. Fernandez-Calotti, G. Salamone, S. Raiden, J. Sanjurjo, and J. R. Geffner
Acidosis Improves Uptake of Antigens and MHC Class I-Restricted Presentation by Dendritic Cells
J. Immunol., March 1, 2004; 172(5): 3196 - 3204.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
Y. Ito, M. Son, S. Sato, T. Ohashi, M. Kondo, K. Shimokata, and H. Kume
Effects of Fluoranthene, a Polycyclic Aromatic Hydrocarbon, on cAMP-Dependent Anion Secretion in Human Airway Epithelia
J. Pharmacol. Exp. Ther., February 1, 2004; 308(2): 651 - 657.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H.-W. Shin, C. M. Rose-Gottron, D. M. Cooper, R. L. Newcomb, and S. C. George
Airway diffusing capacity of nitric oxide and steroid therapy in asthma
J Appl Physiol, January 1, 2004; 96(1): 65 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. D. Moloney, S. E. Mumby, R. Gajdocsi, J. H. Cranshaw, S. A. Kharitonov, G. J. Quinlan, and M. J. Griffiths
Exhaled Breath Condensate Detects Markers of Pulmonary Inflammation after Cardiothoracic Surgery
Am. J. Respir. Crit. Care Med., January 1, 2004; 169(1): 64 - 69.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Vaughan, L. Ngamtrakulpanit, T.N. Pajewski, R. Turner, T-A. Nguyen, A. Smith, P. Urban, S. Hom, B. Gaston, and J. Hunt
Exhaled breath condensate pH is a robust and reproducible assay of airway acidity
Eur. Respir. J., December 1, 2003; 22(6): 889 - 894.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
W S Tunnicliffe, R M Harrison, F J Kelly, C Dunster, and J G Ayres
The effect of sulphurous air pollutant exposures on symptoms, lung function, exhaled nitric oxide, and nasal epithelial lining fluid antioxidant concentrations in normal and asthmatic adults
Occup. Environ. Med., November 1, 2003; 60(11): e15 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. M. Effros, B. Gaston, A. Mutti, and M. Corradi
Saving the Breath Condensate Approach
Am. J. Respir. Crit. Care Med., November 1, 2003; 168(9): 1129 - 1132.
[Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. M. Nikolaidis, N. Zimmermann, N. E. King, A. Mishra, S. M. Pope, F. D. Finkelman, and M. E. Rothenberg
Trefoil Factor-2 Is an Allergen-Induced Gene Regulated by Th2 Cytokines and STAT6 in the Lung
Am. J. Respir. Cell Mol. Biol., October 1, 2003; 29(4): 458 - 464.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
F L M Ricciardolo, M C Timmers, J K Sont, G Folkerts, and P J Sterk
Effect of bradykinin on allergen induced increase in exhaled nitric oxide in asthma
Thorax, October 1, 2003; 58(10): 840 - 845.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Gessner, S. Hammerschmidt, H. Kuhn, T. Lange, L. Engelmann, J. Schauer, and H. Wirtz
Exhaled Breath Condensate Nitrite and Its Relation to Tidal Volume in Acute Lung Injury
Chest, September 1, 2003; 124(3): 1046 - 1052.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Zelenina, A. A. Bondar, S. Zelenin, and A. Aperia
Nickel and Extracellular Acidification Inhibit the Water Permeability of Human Aquaporin-3 in Lung Epithelial Cells
J. Biol. Chem., August 8, 2003; 278(32): 30037 - 30043.
[Abstract] [Full Text] [PDF]