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Am. J. Respir. Crit. Care Med., Volume 161, Number 3, March 2000, 1016-1021

Goblet Cell Hyperplasia and Epithelial Inflammation in Peripheral Airways of Smokers with Both Symptoms of Chronic Bronchitis and Chronic Airflow Limitation

MARINA SAETTA, GRAZIELLA TURATO, SIMONETTA BARALDO, ANNALISA ZANIN, FAUSTO BRACCIONI, CRISTINA E. MAPP, PIERO MAESTRELLI, GIORGIO CAVALLESCO, ALBERTO PAPI, and LEONARDO M. FABBRI

Institute of Occupational Medicine, University of Padova; Institute of Respiratory Diseases and Department of Surgical Pathology, University of Ferrara; and Department of Pulmonary Diseases, University of Modena, Italy

To quantify the number of goblet cells and inflammatory cells in the epithelium of peripheral airways in smokers with both symptoms of chronic bronchitis and chronic airflow limitation, we examined surgical specimens obtained from 25 subjects undergoing lung resection for localized pulmonary lesions: 10 smokers with symptoms of chronic bronchitis and chronic airflow limitation, six asymptomatic smokers with normal lung function, and nine nonsmoking control subjects. Peripheral airways were examined with histochemical methods to identify goblet cells and with immunohistochemical methods to identify total leukocytes (CD45+ cells), neutrophils, macrophages, CD4+ and CD8+ cells in the epithelium. When compared with nonsmokers, smokers with both symptoms of chronic bronchitis and chronic airflow limitation had an increased number of goblet cells (p < 0.01), CD45+ cells (p < 0.01), macrophages (p < 0.05), and CD8+ cells (p < 0.01) in the epithelium of peripheral airways. When all the smokers were grouped together, they showed an increased number of neutrophils (p < 0.05) along with an increased number of goblet cells, CD45+ cells, macrophages and CD8+ cells (p < 0.05) compared with nonsmokers. In conclusion, smokers with both symptoms of chronic bronchitis and chronic airflow limitation have an increased number of goblet cells and inflammatory cells in the epithelium of peripheral airways. Saetta M, Turato G, Baraldo S, Zanin A, Braccioni F, Mapp CE, Maestrelli P, Cavallesco G, Papi A, Fabbri LM. Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation.




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