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Am. J. Respir. Crit. Care Med., Volume 161, Number 2, February 2000, 567-573

Aldosterone Regulates Na,K-ATPase and Increases Lung Edema Clearance in Rats

WALTER G. OLIVERA, DAVID E. CICCOLELLA, NORA BARQUIN, KAREN M. RIDGE, DAVID H. RUTSCHMAN, DONOVAN B. YEATES, and JACOB I. SZNAJDER

Pulmonary and Critical Care Medicine Division, Northwestern University Medical School, Michael Reese Hospital, University of Illinois at Chicago, and Northeastern Illinois University, Chicago, Illinois

Aldosterone increases the Na,K-ATPase function in renal cells involved in active Na+ transport. Because the alveolar type 2 (AT2) cells participate in active Na+ transport, we studied whether aldosterone regulates the Na,K-ATPase in rat AT2 cells and whether aldosterone delivered by aerosols to spontaneously breathing rats affects edema clearance in a model of isolated-perfused lungs. The AT2 cells treated with aldosterone had increased Na,K-ATPase beta 1-subunit mRNA and protein, which was associated with a 4-fold increase in the Na,K-ATPase hydrolytic activity and the ouabain-sensitive 86Rb+ uptake. In physiologic experiments, 24 h after aldosterone was delivered by aerosols to the rat air spaces, the active Na+ transport and lung edema clearance increased by ~ 53% as compared with control rats and rats in which saline aerosols were delivered. The data suggest that increased active Na+ transport and lung edema clearance induced by aldosterone is probably due to Na,K-ATPase regulation in alveolar epithelial cells. Conceivably, aldosterone may be used as a strategy to increase lung edema clearance. Olivera WG, Ciccolella DE, Barquin N, Ridge KM, Rutschman DH, Yeates DB, Sznajder JI. Aldosterone regulates Na,K-ATPase and increases lung edema clearance in rats.




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