help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SHAPIRO, G.
Right arrow Articles by SHAH, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SHAPIRO, G.
Right arrow Articles by SHAH, T.

Am. J. Respir. Crit. Care Med., Volume 161, Number 2, February 2000, 527-534

Combined Salmeterol 50 µg and Fluticasone Propionate 250 µg in the Diskus Device for the Treatment of Asthma

GAIL SHAPIRO, WILLIAM LUMRY, JAMES WOLFE, JOHN GIVEN, MARTHA V. WHITE, ANITA WOODRING, LESLIE BAITINGER, KAREN HOUSE, BARBARA PRILLAMAN, and TUSHAR SHAH

A.S.T.H.M.A., Inc., Seattle, Washington; Allergy and Asthma Research Associates, Dallas, Texas; Allergy and Asthma Associates of Santa Clara Valley, San Jose, California; Allergy and Respiratory Center, Canton, Ohio; Institute for Asthma and Allergy, Washington, DC; and Glaxo Wellcome Inc., Research Triangle Park, North Carolina

Three hundred forty-nine patients with asthma previously treated with medium doses of inhaled corticosteroids during a 2-wk, single-blind, run-in period were randomized to treatment with salmeterol 50 µg combined with fluticasone propionate (FP) 250 µg, salmeterol 50 µg, FP 250 µg, or placebo, each given twice daily through a Diskus device for 12 wk. Mean change in FEV1 at endpoint was significantly (p =< 0.001) greater with the salmeterol/FP combination product (0.48 L) than with placebo (-0.11 L), salmeterol (0.05 L), or FP (0.25 L). The combination product significantly increased the area under the 12-h serial FEV1 curve relative to baseline over that with placebo, salmeterol, or FP at Day 1, Week 1, and Week 12 (p =< 0.025). Patients in the combination-product group had a significantly greater probability of remaining in the study without being withdrawn because of worsening asthma than did patients in the placebo, salmeterol, or FP groups (p =< 0.002). The combination product significantly increased (p < 0.001) morning PEF at endpoint (53.5 L/min) as compared with placebo (-14 L/min), salmeterol (-11.6 L/min), or FP (15.2 L/min). The combination product significantly (p =< 0.011) reduced asthma symptom scores and supplemental albuterol use, and significantly increased the percentage of nights with no awakenings as compared with placebo, salmeterol, and FP (p =< 0.016). Combination treatment with salmeterol 50 µg and FP 250 µg given twice daily from the Diskus device provided better asthma control and greater improvement in pulmonary function than did the individual agents, and may simplify the management of asthma in patients who need both classes of drugs for optimal control of their disease. Shapiro G, Lumry W, Wolfe J, Given J, White MV, Woodring A, Baitinger L, House K, Prillaman B, Shah T. Combined salmeterol 50 µg and fluticasone propionate 250 µg in the Diskus device for the treatment of asthma.




This article has been cited by other articles:


Home page
 ANN INTERN MEDHome page
E. Bateman, H. Nelson, J. Bousquet, K. Kral, L. Sutton, H. Ortega, and S. Yancey
Meta-analysis: Effects of Adding Salmeterol to Inhaled Corticosteroids on Serious Asthma-Related Events
Ann Intern Med, July 1, 2008; 149(1): 33 - 42.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Masoli, M. Weatherall, S. Holt, P. Shirtcliffe, and R. Beasley
Inhaled fluticasone propionate and adrenal effects in adult asthma: systematic review and meta-analysis
Eur. Respir. J., November 1, 2006; 28(5): 960 - 967.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Humbert
The Right Tools at the Right Time
Chest, July 1, 2006; 130(1_suppl): 29S - 40S.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
S. R. Salpeter, N. S. Buckley, T. M. Ormiston, and E. E. Salpeter
Meta-Analysis: Effect of Long-Acting {beta}-Agonists on Severe Asthma Exacerbations and Asthma-Related Deaths
Ann Intern Med, June 20, 2006; 144(12): 904 - 912.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. F. Donohue and J. A. Ohar
Effects of Corticosteroids on Lung Function in Asthma and Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, November 1, 2004; 1(3): 152 - 160.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. D. Bateman, H. A. Boushey, J. Bousquet, W. W. Busse, T. J. H. Clark, R. A. Pauwels, S. E. Pedersen, and for the GOAL Investigators Group
Can Guideline-defined Asthma Control Be Achieved?: The Gaining Optimal Asthma ControL Study
Am. J. Respir. Crit. Care Med., October 15, 2004; 170(8): 836 - 844.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
M Masoli, M Weatherall, S Holt, and R Beasley
Systematic review of the dose-response relation of inhaled fluticasone propionate
Arch. Dis. Child., October 1, 2004; 89(10): 902 - 907.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. J. Larj and E. R. Bleecker
Therapeutic Responses in Asthma and COPD: Corticosteroids
Chest, August 1, 2004; 126(2_suppl_1): 138S - 149S.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. D. Sin, J. Man, H. Sharpe, W. Q. Gan, and S. F. P. Man
Pharmacological Management to Reduce Exacerbations in Adults With Asthma: A Systematic Review and Meta-analysis
JAMA, July 21, 2004; 292(3): 367 - 376.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. J. Coffey, B. Wilfond, and L. F. Ross
Ethical Assessment of Clinical Asthma Trials Including Children Subjects
Pediatrics, January 1, 2004; 113(1): 87 - 94.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. A. Hanania, P. Darken, D. Horstman, C. Reisner, B. Lee, S. Davis, and T. Shah
The Efficacy and Safety of Fluticasone Propionate (250 {micro}g)/Salmeterol (50 {micro}g) Combined in the Diskus Inhaler for the Treatment of COPD
Chest, September 1, 2003; 124(3): 834 - 843.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. P. Currie, D. K. C. Lee, K. Haggart, C. E. Bates, and B. J. Lipworth
Effects of Montelukast on Surrogate Inflammatory Markers in Corticosteroid-treated Patients with Asthma
Am. J. Respir. Crit. Care Med., May 1, 2003; 167(9): 1232 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.B. Soriano, J. Vestbo, N.B. Pride, V. Kiri, C. Maden, and W.C. Maier
Survival in COPD patients after regular use of fluticasone propionate and salmeterol in general practice
Eur. Respir. J., October 1, 2002; 20(4): 819 - 825.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E.D. Bateman, L.F. Frith, and G.L. Braunstein
Achieving guideline-based asthma control: does the patient benefit?
Eur. Respir. J., September 1, 2002; 20(3): 588 - 596.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.J. Barnes
Scientific rationale for inhaled combination therapy with long-acting {beta}2-agonists and corticosteroids
Eur. Respir. J., January 1, 2002; 19(1): 182 - 191.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Allergic Rhinitis in AJRCCM 2000
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1559 - 1580.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. C. KIPS and R. A. PAUWELS
Long-acting Inhaled beta 2-Agonist Therapy in Asthma
Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 923 - 932.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. J. CALHOUN, H. S. NELSON, R. A. NATHAN, P. J. PEPSIN, C. KALBERG, A. EMMETT, K. A. RICKARD, and P. DORINSKY
Comparison of Fluticasone Propionate-Salmeterol Combination Therapy and Montelukast in Patients Who Are Symptomatic on Short-acting beta 2-Agonists Alone
Am. J. Respir. Crit. Care Med., September 1, 2001; 164(5): 759 - 763.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J C Kips and R A Pauwels
Low dose inhaled corticosteroids and the prevention of death from asthma
Thorax, September 1, 2001; 56(90002): ii74 - 78.
[Full Text] [PDF]

Home page
 ChestHome page
J. E. Fish, E. Israel, J. J. Murray, A. Emmett, R. Boone, S. W. Yancey, and K. A. Rickard
Salmeterol Powder Provides Significantly Better Benefit Than Montelukast in Asthmatic Patients Receiving Concomitant Inhaled Corticosteroid Therapy
Chest, August 1, 2001; 120(2): 423 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Beasley, P.J. Sterk, H.A.M. Kerstjens, and M. Decramer
Comparative studies of inhaled corticosteroids in asthma
Eur. Respir. J., April 1, 2001; 17(4): 579 - 580.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
E.D. Bateman, J. Bousquet, and G.L. Braunstein
Is overall asthma control being achieved? A hypothesis-generating study
Eur. Respir. J., April 1, 2001; 17(4): 589 - 595.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. E. Kass and T. Bartter
The Labyrinth of Asthma Therapy : Lost in the Choices
Chest, October 1, 2000; 118(4): 891 - 893.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society 		  CCM abstracts