help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ULBRECHT, M.
Right arrow Articles by WEISS, E. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ULBRECHT, M.
Right arrow Articles by WEISS, E. H.

Am. J. Respir. Crit. Care Med., Volume 161, Number 2, February 2000, 469-474

Association of beta 2-Adrenoreceptor Variants with Bronchial Hyperresponsiveness

MATTHIAS ULBRECHT, MARKUS THOMAS HERGETH, MATTHIAS WJST, JOACHIM HEINRICH, HEIKE BICKEBÖLLER, HEINZ-ERICH WICHMANN, and ELISABETH HELENE WEISS

Institut für Anthropologie und Humangenetik der Ludwig-Maximilians-Universität München, München, Germany; Institut für Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Oberschleißheim, Germany; and Institut für Medizinische Statistik und Epidemiologie der Technischen Universität München, München, Germany

Because of its involvement in the regulation of airway tone, the beta 2-adrenoreceptor is considered a candidate for bronchial hyperresponsiveness (BHR) associated with asthma. This notion is supported by several reports that have implicated the chromosomal region 5q31-q33 harboring the gene for the beta 2-adrenoreceptor in the genetics of asthma and related phenotypes. We performed a population-based association study focusing on BHR as a qualitative trait and omitting other asthma-related phenotypes. From a German population sample of 1,150 individuals we extracted all 152 bronchohyperreactive probands, who were compared with 295 bronchonormoreactive control subjects. All individuals were genotyped for three single nucleotide polymorphisms of the beta 2-adrenoreceptor gene resulting in variants at the amino acid positions 16, 27, and 164. The genotyping protocol used allowed the determination of haplotypes of these polymorphisms. Whereas no individual polymorphism was associated with BHR, the Gly16/Gln27/Th164 haplotype was significantly underrepresented in the case group indicating a protective effect of this haplotype with regard to BHR. Upon reanalysis by sex a significant association persisted only for female probands. Ulbrecht M, Hergeth MT, Wjst M, Heinrich J, Bickeböller H, Wichmann H-E, Weiss EH. Association of beta 2-adrenoreceptor variants with bronchial hyperresponsiveness.




This article has been cited by other articles:


Home page
 ChestHome page
C. V. Scirica and J. C. Celedon
Genetics of Asthma: Potential Implications for Reducing Asthma Disparities
Chest, November 1, 2007; 132(5_suppl): 770S - 781S.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Derre, M. Corvaisier, B. Charreau, A. Moreau, E. Godefroy, A. Moreau-Aubry, F. Jotereau, and N. Gervois
Expression and Release of HLA-E by Melanoma Cells and Melanocytes: Potential Impact on the Response of Cytotoxic Effector Cells.
J. Immunol., September 1, 2006; 177(5): 3100 - 3107.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Y. Fukui, N. Hizawa, D. Takahashi, Y. Maeda, E. Jinushi, S. Konno, and M. Nishimura
Association Between Nonspecific Airway Hyperresponsiveness and Arg16Gly {beta}2-Adrenergic Receptor Gene Polymorphism in Asymptomatic Healthy Japanese Subjects.
Chest, August 1, 2006; 130(2): 449 - 454.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. M. Hunninghake, S. T. Weiss, and J. C. Celedon
Asthma in Hispanics
Am. J. Respir. Crit. Care Med., January 15, 2006; 173(2): 143 - 163.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
E Melen, H Gullsten, M Zucchelli, A Lindstedt, F Nyberg, M Wickman, G Pershagen, and J Kere
Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation
J. Med. Genet., December 1, 2004; 41(12): e123 - e123.
[Full Text] [PDF]

Home page
 ChestHome page
A. A. Litonjua, E. K. Silverman, K. G. Tantisira, D. Sparrow, J. S. Sylvia, and S. T. Weiss
{beta}2-Adrenergic Receptor Polymorphisms and Haplotypes Are Associated With Airways Hyperresponsiveness Among Nonsmoking Men
Chest, July 1, 2004; 126(1): 66 - 74.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
L Joos, T D Weir, J E Connett, N R Anthonisen, R Woods, P D Pare, and A J Sandford
Polymorphisms in the {beta}2 adrenergic receptor and bronchodilator response, bronchial hyperresponsiveness, and rate of decline in lung function in smokers
Thorax, August 1, 2003; 58(8): 703 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
G. Duetsch, T. Illig, S. Loesgen, K. Rohde, N. Klopp, N. Herbon, H. Gohlke, J. Altmueller, and M. Wjst
STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study
Hum. Mol. Genet., March 1, 2002; 11(6): 613 - 621.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. HAKONARSON, U. S. BJORNSDOTTIR, E. OSTERMANN, T. ARNASON, A. E. ADALSTEINSDOTTIR, E. HALAPI, D. SHKOLNY, K. KRISTJANSSON, S. A. GUDNADOTTIR, M. L. FRIGGE, et al.
Allelic Frequencies and Patterns of Single-nucleotide Polymorphisms in Candidate Genes for Asthma and Atopy in Iceland
Am. J. Respir. Crit. Care Med., December 1, 2001; 164(11): 2036 - 2044.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Allergic Rhinitis in AJRCCM 2000
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1559 - 1580.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society