Am. J. Respir. Crit. Care Med.,
Volume 161, Number 1, January 2000, 64-72
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
800 µg or equivalent daily) by switching them to budesonide 200 µg daily given
from a dry-powder inhaler (Turbohaler). Fifteen subjects were enrolled and were seen twice weekly
for 8 wk after steroid reduction. At each visit, exhaled nitric oxide (NO), and methacholine airway responsiveness were measured and spirometry and sputum induction were performed. Mild exacerbation was defined as: (1) a decrease in morning peak expiratory flow (PEF) of 
2-agonist
to eight or more puffs daily. Eight subjects did not develop exacerbations during the 8-wk study, whereas seven subjects developed mild exacerbations at Week 4 (n = 1), Week 6 (n = 1), and Week 8 (n = 5). The only significant difference between these two groups at baseline was a higher baseline sputum eosinophil count in subjects with subsequent exacerbations (p < 0.05). The increases in sputum eosinophils and exhaled NO were correlated with decreases in airway function, including decreases in morning PEF and FEV1. However, multiple regression analysis suggested that the change in
sputum eosinophils is a potentially useful marker in predicting loss of asthma control reflected by loss
of airway function. Jatakanon A, Lim S, Barnes PJ. Changes in sputum eosinophils predict loss
of asthma control.
 |
|
 |
|
  H. K. Reddel, D. R. Taylor, E. D. Bateman, L.-P. Boulet, H. A. Boushey, W. W. Busse, T. B. Casale, P. Chanez, P. L. Enright, P. G. Gibson, et al. An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations: Standardizing Endpoints for Clinical Asthma Trials and Clinical Practice Am. J. Respir. Crit. Care Med., July 1, 2009; 180(1): 59 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Papi, G. Caramori, I. M. Adcock, and P. J. Barnes Rescue Treatment in Asthma: More Than As-Needed Bronchodilation Chest, June 1, 2009; 135(6): 1628 - 1633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Haldar, C. E. Brightling, B. Hargadon, S. Gupta, W. Monteiro, A. Sousa, R. P. Marshall, P. Bradding, R. H. Green, A. J. Wardlaw, et al. Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma N. Engl. J. Med., March 5, 2009; 360(10): 973 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D R Taylor Risk assessment in asthma and COPD: a potential role for biomarkers? Thorax, March 1, 2009; 64(3): 261 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Rodway, J Choi, L. Hoffman, and J. Sethi Exhaled nitric oxide in the diagnosis and management of asthma: clinical implications Chronic Respiratory Disease, February 1, 2009; 6(1): 19 - 29. [Abstract] [PDF]
|
|
|
|
|
|
P. Haldar, I. D. Pavord, D. E. Shaw, M. A. Berry, M. Thomas, C. E. Brightling, A. J. Wardlaw, and R. H. Green Cluster Analysis and Clinical Asthma Phenotypes Am. J. Respir. Crit. Care Med., August 1, 2008; 178(3): 218 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. Lim and C. Mottram The Use of Fraction of Exhaled Nitric Oxide in Pulmonary Practice Chest, May 1, 2008; 133(5): 1232 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Michils, S. Baldassarre, and A. Van Muylem Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients Eur. Respir. J., March 1, 2008; 31(3): 539 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Maneechotesuwan, S. Essilfie-Quaye, S. A. Kharitonov, I. M. Adcock, and P. J. Barnes Loss of Control of Asthma Following Inhaled Corticosteroid Withdrawal Is Associated With Increased Sputum Interleukin-8 and Neutrophils Chest, July 1, 2007; 132(1): 98 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brindicci, K. Ito, P. J. Barnes, and S. A. Kharitonov Differential Flow Analysis of Exhaled Nitric Oxide in Patients With Asthma of Differing Severity Chest, May 1, 2007; 131(5): 1353 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kodric, A. N. Shah, L. M. Fabbri, and M. Confalonieri An Investigation of Airway Acidification in Asthma Using Induced Sputum: A Study of Feasibility and Correlation Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 905 - 910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J M FitzGerald and P G Gibson Asthma exacerbations {middle dot} 4: Prevention. Thorax, November 1, 2006; 61(11): 992 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D R Taylor, M W Pijnenburg, A D Smith, and J C D Jongste Exhaled nitric oxide measurements: clinical application and interpretation Thorax, September 1, 2006; 61(9): 817 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Paraskakis, C. Brindicci, L. Fleming, R. Krol, S. A. Kharitonov, N. M. Wilson, P. J. Barnes, and A. Bush Measurement of Bronchial and Alveolar Nitric Oxide Production in Normal Children and Children with Asthma Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 260 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Gelb, C. Flynn Taylor, C. M. Shinar, C. Gutierrez, and N. Zamel Role of Spirometry and Exhaled Nitric Oxide To Predict Exacerbations in Treated Asthmatics Chest, June 1, 2006; 129(6): 1492 - 1499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Green, C. E. Brightling, S. McKenna, B. Hargadon, N. Neale, D. Parker, C. Ruse, I. P. Hall, and I. D. Pavord Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness Eur. Respir. J., June 1, 2006; 27(6): 1144 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Brightling Clinical Applications of Induced Sputum Chest, May 1, 2006; 129(5): 1344 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 ATS Workshop Proceedings: Exhaled Nitric Oxide and Nitric Oxide Oxidative Metabolism in Exhaled Breath Condensate. Proceedings of the ATS, January 1, 2006; 3(2): 131 - 145. [Full Text] [PDF]
|
|
|
|
|
|
W. A. Biernacki, S. A. Kharitonov, H. M. Biernacka, and P. J. Barnes Effect of Montelukast on Exhaled Leukotrienes and Quality of Life in Asthmatic Patients Chest, October 1, 2005; 128(4): 1958 - 1963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. J. van Rensen, J. K. Sont, C. E. Evertse, L. N. A. Willems, T. Mauad, P. S. Hiemstra, P. J. Sterk, and the AMPUL Study Group Bronchial CD8 Cell Infiltrate and Lung Function Decline in Asthma Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 837 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Belvisi, D. S. Bundschuh, M. Stoeck, S. Wicks, S. Underwood, C. H. Battram, E.-B. Haddad, S. E. Webber, and M. L. Foster Preclinical Profile of Ciclesonide, a Novel Corticosteroid for the Treatment of Asthma J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 568 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Ratnawati and P S Thomas Exhaled nitric oxide in paediatric asthma Chronic Respiratory Disease, July 1, 2005; 2(3): 163 - 174. [Abstract] [PDF]
|
|
|
|
|
|
A. Zacharasiewicz, N. Wilson, C. Lex, E. M. Erin, A. M. Li, T. Hansel, M. Khan, and A. Bush Clinical Use of Noninvasive Measurements of Airway Inflammation in Steroid Reduction in Children Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1077 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M W Pijnenburg, W Hofhuis, W C Hop, and J C De Jongste Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission Thorax, March 1, 2005; 60(3): 215 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Baur and L. Barbinova Latex allergen exposure increases exhaled nitric oxide in symptomatic healthcare workers Eur. Respir. J., February 1, 2005; 25(2): 309 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Foresi, B. Mastropasqua, A. Chetta, R. D'Ippolito, R. Testi, D. Olivieri, and A. Pelucchi Step-Down Compared to Fixed-Dose Treatment With Inhaled Fluticasone Propionate in Asthma Chest, January 1, 2005; 127(1): 117 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kharitonov and P. J. Barnes Effects of Corticosteroids on Noninvasive Biomarkers of Inflammation in Asthma and Chronic Obstructive Pulmonary Disease Proceedings of the ATS, November 1, 2004; 1(3): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Belvisi Regulation of Inflammatory Cell Function by Corticosteroids Proceedings of the ATS, November 1, 2004; 1(3): 207 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Roberts, C Hurley, A Bush, and G Lack Longitudinal study of grass pollen exposure, symptoms, and exhaled nitric oxide in childhood seasonal allergic asthma Thorax, September 1, 2004; 59(9): 752 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Colice Categorizing Asthma Severity: An Overview of National Guidelines Clin. Med. Res., August 1, 2004; 2(3): 155 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Dent, C. Hadjicharalambous, T. Yoshikawa, R. L. C. Handy, J. Powell, I. K. Anderson, R. Louis, D. E. Davies, and R. Djukanovic Contribution of Eotaxin-1 to Eosinophil Chemotactic Activity of Moderate and Severe Asthmatic Sputum Am. J. Respir. Crit. Care Med., May 15, 2004; 169(10): 1110 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Castro, S. R. Bloch, M. V. Jenkerson, S. DeMartino, D. L. Hamilos, R. B. Cochran, X. E. L. Zhang, H. Wang, J. P. Bradley, K. B. Schechtman, et al. Asthma Exacerbations after Glucocorticoid Withdrawal Reflects T Cell Recruitment to the Airway Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 842 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Mahut, C. Delacourt, F. Zerah-Lancner, J. De Blic, A. Harf, and C. Delclaux Increase in Alveolar Nitric Oxide in the Presence of Symptoms in Childhood Asthma Chest, March 1, 2004; 125(3): 1012 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Prieto, L. Bruno, V. Gutierrez, S. Uixera, C. Perez-Frances, A. Lanuza, and A. Ferrer Airway Responsiveness to Adenosine 5'-Monophosphate and Exhaled Nitric Oxide Measurements: Predictive Value as Markers for Reducing the Dose of Inhaled Corticosteroids in Asthmatic Subjects Chest, October 1, 2003; 124(4): 1325 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Combescure, P. Chanez, P. Saint-Pierre, J-P. Daures, H. Proudhon, and P. Godard Assessment of variations in control of asthma over time Eur. Respir. J., August 1, 2003; 22(2): 298 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C E Brightling, F A Symon, S S Birring, P Bradding, A J Wardlaw, and I D Pavord Comparison of airway immunopathology of eosinophilic bronchitis and asthma Thorax, June 1, 2003; 58(6): 528 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.A. Kharitonov, F. Gonio, C. Kelly, S. Meah, and P.J. Barnes Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children Eur. Respir. J., March 1, 2003; 21(3): 433 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F L M Ricciardolo Multiple roles of nitric oxide in the airways Thorax, February 1, 2003; 58(2): 175 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Romagnoli, I. Vachier, P. Tarodo de la Fuente, H. Meziane, C. Chavis, J. Bousquet, P. Godard, and P. Chanez Eosinophilic inflammation in sputum of poorly controlled asthmatics Eur. Respir. J., December 1, 2002; 20(6): 1370 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S A Kharitonov, L E Donnelly, P Montuschi, M Corradi, J V Collins, and P J Barnes Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma Thorax, October 1, 2002; 57(10): 889 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zuany-Amorim, C. Manlius, A. Trifilieff, L. R. Brunet, G. Rook, G. Bowen, G. Pay, and C. Walker Long-Term Protective and Antigen-Specific Effect of Heat-Killed Mycobacterium vaccae in a Murine Model of Allergic Pulmonary Inflammation J. Immunol., August 1, 2002; 169(3): 1492 - 1499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Faul, E. A. Demers, C. M. Burke, and L. W. Poulter Alterations in Airway Inflammation and Lung Function During Corticosteroid Therapy for Atopic Asthma* Chest, May 1, 2002; 121(5): 1414 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G W Chalmers, K J Macleod, S A Little, L J Thomson, C P McSharry, and N C Thomson Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma Thorax, March 1, 2002; 57(3): 226 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. TOBIN Asthma, Airway Biology, and Allergic Rhinitis in AJRCCM 2000 Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1559 - 1580. [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kharitonov and P. J. Barnes Does Exhaled Nitric Oxide Reflect Asthma Control? . Yes, It Does! Am. J. Respir. Crit. Care Med., September 1, 2001; 164(5): 727 - 728. [Full Text] [PDF]
|
|
|
|
|
|
S. L. JONES, J. KITTELSON, J. O. COWAN, E. M. FLANNERY, R. J. HANCOX, C. R. MCLACHLAN, and D. R. TAYLOR The Predictive Value of Exhaled Nitric Oxide Measurements in Assessing Changes in Asthma Control Am. J. Respir. Crit. Care Med., September 1, 2001; 164(5): 738 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Van Den BERGE, R. J. MEIJER, H. A. M. KERSTJENS, D. M. de REUS, G. H. KOETER, H. F. KAUFFMAN, and D. S. POSTMA PC20 Adenosine 5'-Monophosphate Is More Closely Associated with Airway Inflammation in Asthma Than PC20 Methacholine Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1546 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. KHARITONOV and P. J. BARNES Exhaled Markers of Pulmonary Disease Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1693 - 1722. [Full Text] [PDF]
|
|
|
|
|
|
J. D. LEUPPI, C. M. SALOME, C. R. JENKINS, S. D. ANDERSON, W. XUAN, G. B. MARKS, H. KOSKELA, J. D. BRANNAN, R. FREED, M. ANDERSSON, et al. Predictive Markers of Asthma Exacerbation during Stepwise Dose Reduction of Inhaled Corticosteroids Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 406 - 412. [Abstract] [Full Text]
|
|
|
|
|
|
N Dauletbaev, J Rickmann, K Viel, R Buhl, T-O-F Wagner, and J Bargon Glutathione in induced sputum of healthy individuals and patients with asthma Thorax, January 1, 2001; 56(1): 13 - 18. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Proc. Am. Thorac. Soc. | Am. J. Respir. Cell Mol. Biol. |
