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Am. J. Respir. Crit. Care Med., Volume 161, Number 1, January 2000, 166-170

Daytime Predictors of Sleep Hypoventilation in Duchenne Muscular Dystrophy

CRAIG A. HUKINS and DAVID R. HILLMAN

Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

Sleep hypoventilation is an inevitable consequence of Duchenne muscular dystrophy (DMD), usually preceding daytime respiratory failure. Appropriate scheduling of polysomnography and the introduction of noninvasive ventilation (NIV) during sleep are not defined. Our aim was to determine the parameters of daytime lung function associated with sleep hypoventilation in patients with DMD. As our method we chose a prospective comparison of wakeful respiratory function (spirometry, lung volumes, maximal mouth pressures, arterial blood gases) with outcomes of polysomnography. All measurements were made with subjects breathing air. Nineteen subjects were studied. The FEV1 was correlated with PaCO2 (r = -0.70, p < 0.001) and base excess (r = -0.68, p < 0.01). All of these parameters were significantly related to sleep oxygenation (proportion of total sleep time spent at an SaO2 =< 90% [TST < 90%]). An FEV1 < 40% was a sensitive (91%) but not specific (50%) indicator of sleep hypoventilation (TST < 90% of >=  2%); a PaCO2 of >=  45 mm Hg was an equally sensitive (91%) but more specific (75%) indicator while a base excess of >=  4 mmol/L was highly specific (100%) but less sensitive (55%). After introduction of NIV during sleep (n = 8), there was a significant reduction in wakeful PaCO2 (54 ± 7.4 to 49.1 ± 4 mm Hg, p < 0.02) over 0.9 ± 0.4 yr despite a further decline in FEV1 (0.84 ± 0.46 to 0.64 ± 0.39 L, p < 0.05). We conclude that in patients with DMD, (1) arterial blood gases should be performed once the FEV1 falls below 40% of the predicted value; (2) polysomnography should be considered when the PaCO2 is >=  45 mm Hg, particularly if the base excess is >=  4 mmol/L; (3) the decrease in wakeful PaCO2 after NIV administered during sleep implicates sleep hypoventilation in the pathogenesis of respiratory failure; and (4) impaired ventilatory drive is a possible mechanism for respiratory failure, as the NIV-associated decrease in wakeful PaCO2 occurs despite a further decline in ventilatory capacity, suggesting continuing deterioration in respiratory muscle function. Hukins CA, Hillman DR. Daytime predictors of sleep hypoventilation in Duchenne muscular dystrophy.




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