help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BOUFERRACHE, B.
Right arrow Articles by GAULTIER, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BOUFERRACHE, B.
Right arrow Articles by GAULTIER, C.

Am. J. Respir. Crit. Care Med., Volume 161, Number 1, January 2000, 160-165

The Hyperoxic Test in Infants Reinvestigated

BELKACEM BOUFERRACHE, SLAVI FILTCHEV, ANDRÉ LEKE, QING MARBAIX-LI, MICHEL FREVILLE, and CLAUDE GAULTIER

URAPC (EA 2088), School of Medicine, Amiens, and Department of Physiology, INSERM-CRI 9701, Robert Debré Hospital, Paris, France

The hyperoxic test (HT) examines peripheral chemoreceptor function (PCF) by measuring the decrease in ventilation (V E) after 100% O2 inhalation. A 30-s HT has been previously used in infants with calculation of the ventilatory response (VR) as the mean percentage change in V E during HT as compared with normoxia. However, it has been shown that during hyperoxia V E rises secondarily after the initial drop because of loss of PCF. We hypothesized that the mean V E change over a 30-s HT may underestimate the strength of PCF and may be poorly reproducible. We performed breath-by-breath analysis during 30-s HTs, calculating VR at the response time (RT) defined as the time from HT onset to the first significant HT-related change in V E. Eighteen infants (postnatal age, 21 ± 4 d) underwent two HTs (quiet sleep, face mask attached to a pneumotachograph, and inspired and expired O2 and CO2 fractions measured using mass spectrometry). V E, VT, and VT/TI decreases at the RT were significantly greater than the corresponding means (-21 ± 7 versus -15 ± 7%, -21 ± 8 versus -13 ± 8%, and -22 ± 11 versus -17 ± 11%, respectively). Intra-individual coefficients of variation of V E, VT and VT/TI were significantly smaller when RT values were considered rather than means. We conclude that calculation of the VR to HT at RT improves assessment of PCF and enhances HT reproducibility in infants. Bouferrache B, Filtchev S, Leke A, Marbaix-Li Q, Freville M, Gaultier C. The hyperoxic test in infants reinvestigated.




This article has been cited by other articles:


Home page
 Eur Respir JHome page
F. Lofaso, S. Dauger, B. Matrot, G. Vardon, C. Gaultier, and J. Gallego
Inhibitory effects of repeated hyperoxia on breathing in newborn mice
Eur. Respir. J., January 1, 2007; 29(1): 18 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Chardon, V. Bach, F. Telliez, V. Cardot, P. Tourneux, A. Leke, and J.-P. Libert
Effect of caffeine on peripheral chemoreceptor activity in premature neonates: interaction with sleep stages
J Appl Physiol, June 1, 2004; 96(6): 2161 - 2166.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
M Katz-Salamon
Delayed chemoreceptor responses in infants with apnoea
Arch. Dis. Child., March 1, 2004; 89(3): 261 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Statement on the Care of the Child with Chronic Lung Disease of Infancy and Childhood
Am. J. Respir. Crit. Care Med., August 1, 2003; 168(3): 356 - 396.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. BOUFERRACHE, S. FILTCHEV, A. LEKE, M. FREVILLE, J. GALLEGO, and C. GAULTIER
Comparison of the Hyperoxic Test and the Alternate Breath Test in Infants
Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 206 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Pediatrics, Surfactant, and Cystic Fibrosis in AJRCCM 2000
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1581 - 1594.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Sleep-disordered Breathing, Control of Breathing, Respiratory Muscles, Pulmonary Function Testing, Nitric Oxide, and Bronchoscopy in AJRCCM 2000
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1362 - 1375.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society 		  ATS 2008 State of the Art Course