help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LAING, I. A.
Right arrow Articles by LE SOUËF, P. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LAING, I. A.
Right arrow Articles by LE SOUËF, P. N.

Am. J. Respir. Crit. Care Med., Volume 161, Number 1, January 2000, 124-127

Association between Plasma CC16 Levels, the A38G Polymorphism, and Asthma

INGRID A. LAING, CEDRIC HERMANS, ALFRED BERNARD, PAUL R. BURTON, JACK GOLDBLATT, and PETER N. LE SOUËF

Department of Paediatrics, University of Western Australia, Children's Hospital Medical Centre, Perth, Australia; Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium; Division of Biostatistics and Genetic Epidemiology, TVW Telethon Institute for Child Health Research, West Perth, Australia; and Genetic Services, Princess Margaret Hospital for Children, Perth, Australia

The effect of the A38G polymorphism on Clara cell secretory protein (CC16) gene expression and asthma was investigated by measuring plasma CC16 levels in 100 asthmatic and nonasthmatic children. Restriction digestion determined the A38G genotype and plasma CC16 levels were analyzed using a sensitive latex immunoassay. Asthmatics had lower mean plasma CC16 levels adjusted for age and gender (7.96 µg/L; 95% confidence interval [CI] = 6.79 to 9.31) than nonasthmatic subjects (9.98 µg/L; 95% CI = 8.83 to 11.26) (p = 0.006). Similarly adjusted, mean plasma CC16 levels were also lower in 38A/38A (6.79 µg/L; 95% CI = 4.56 to 9.02) than 38G/38G subjects (10.01 µg/L; 95% CI = 7.90 to 12.12; p = 0.003). The odds ratio for asthma diagnosis of 38A/38A subjects was 4.78 (95% CI = 1.08 to 21.18; p = 0.04) compared with 38G/38G subjects. However, this was reduced when corrected from plasma CC16 level, suggesting that the odds of asthma was largely mediated through altered plasma CC16 levels. The 38A sequence was associated with reduced plasma CC16 levels and individuals with lower plasma CC16 levels were more likely to have asthma. This provides further evidence for a significant role of the CC16 gene, 38A allele in the development of asthma. Laing IA, Hermans C, Bernard A, Burton PR, Goldblatt J, Le Souëf PN. Association between plasma CC16 levels, the A38G polymorphism, and asthma.




This article has been cited by other articles:


Home page
 Toxicol PatholHome page
S. J. Bolton, K. Pinnion, C. V. Marshall, E. Wilson, J. E. Barker, V. Oreffo, and M. L. Foster
Changes in Clara Cell 10 kDa Protein (CC10)-positive Cell Distribution in Acute Lung Injury Following Repeated Lipopolysaccharide Challenge in the Rat
Toxicol Pathol, April 1, 2008; 36(3): 440 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. B. Mukherjee, Z. Zhang, and B. S. Chilton
Uteroglobin: A Steroid-Inducible Immunomodulatory Protein That Founded the Secretoglobin Superfamily
Endocr. Rev., December 1, 2007; 28(7): 707 - 725.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. de Burbure, P. Pignatti, M. Corradi, M. Malerba, A. Clippe, X. Dumont, G. Moscato, A. Mutti, and A. Bernard
Uteroglobin-Related Protein 1 and Clara Cell Protein in Induced Sputum of Patients With Asthma and Rhinitis
Chest, January 1, 2007; 131(1): 172 - 179.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. C. Iannuzzi and B. A. Rybicki
Genetics of Sarcoidosis: Candidate Genes and Genome Scans
Proceedings of the ATS, January 1, 2007; 4(1): 108 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. C. Martin, I. A. Laing, S.-K. Khoo, G. Zhang, K. Rueter, L. Teoh, S. Taheri, C. M. Hayden, G. C. Geelhoed, J. Goldblatt, et al.
Acute Asthma in Children: Relationships among CD14 and CC16 Genotypes, Plasma Levels, and Severity
Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 617 - 622.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Janssen, H. Sato, J. C. Grutters, H. J. T. Ruven, R. M. du Bois, R. Matsuura, M. Yamazaki, S. Kunimaru, T. Izumi, K. I. Welsh, et al.
The Clara Cell10 Adenine38Guanine Polymorphism and Sarcoidosis Susceptibility in Dutch and Japanese Subjects
Am. J. Respir. Crit. Care Med., December 1, 2004; 170(11): 1185 - 1187.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
C E Ruse and S G Parker
Genetics and the Dutch Hypothesis
Chronic Respiratory Disease, April 1, 2004; 1(2): 105 - 113.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
M. S. Choi, R. Ray, Z. Zhang, and A. B. Mukherjee
IFN-{gamma} Stimulates the Expression of a Novel Secretoglobin That Regulates Chemotactic Cell Migration and Invasion
J. Immunol., April 1, 2004; 172(7): 4245 - 4252.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Ohchi, N. Shijubo, I. Kawabata, S. Ichimiya, S.-i. Inomata, A. Yamaguchi, Y. Umemori, Y. Itoh, S. Abe, Y. Hiraga, et al.
Polymorphism of Clara Cell 10-kD Protein Gene of Sarcoidosis
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 180 - 186.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
A Bernard, S Carbonnelle, O Michel, S Higuet, C de Burbure, J-P Buchet, C Hermans, X Dumont, and I Doyle
Lung hyperpermeability and asthma prevalence in schoolchildren: unexpected associations with the attendance at indoor chlorinated swimming pools
Occup. Environ. Med., June 1, 2003; 60(6): 385 - 394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. M. Watson, S. D. Reynolds, G. W. Mango, I.-M. Boe, J. Lund, and B. R. Stripp
Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells
Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1523 - L1530.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. J. TOBIN
Asthma, Airway Biology, and Allergic Rhinitis in AJRCCM 2000
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1559 - 1580.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S.-Z. Wang, C. L. Rosenberger, T. M. Espindola, E. G. Barrett, Y. Tesfaigzi, D. E. Bice, and K. S. Harrod
CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model
Am J Physiol Lung Cell Mol Physiol, November 1, 2001; 281(5): L1303 - L1311.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.J.A. Borm and R.P.F. Schins
Genotype and phenotype in susceptibility to coal workers' pneumoconiosis. The use of cytokines in perspective
Eur. Respir. J., July 1, 2001; 18(32_suppl): 127S - 133s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. BERGAMASCHI, G. DE PALMA, P. MOZZONI, S. VANNI, M. V. VETTORI, F. BROECKAERT, A. BERNARD, and A. MUTTI
Polymorphism of Quinone-metabolizing Enzymes and Susceptibility to Ozone-induced Acute Effects
Am. J. Respir. Crit. Care Med., May 1, 2001; 163(6): 1426 - 1431.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2000 American Thoracic Society 		  New Orleans Int'l Conf