Am. J. Respir. Crit. Care Med., Volume 160, Number 6, December 1999, 2006-2011

Assessment of Reliability of Lung Function Screening Programs or Longitudinal Studies

EVA HNIZDO, GAVIN CHURCHYARD, DAVE BARNES, and ROB DOWDESWELL

National Center for Occupational Health, Johannesburg; Arum Health Research, Welkom; Anglogold Health Services, Welkom; and Precious Metal Refiners (Pty) Ltd., Kroonsdal, South Africa

The aim was to determine reliability of lung function measurements performed according to recommendations of the American Thoracic Society (ATS) at a screening program in a large South African gold mine and to determine the usefulness of the reliability coefficient G for monitoring the reliability of lung function measurements in a mass screening program. The reliability coefficient G estimates the amount of random error of measurement, relative to the total variation in a measurement. The coefficient G was calculated as a correlation coefficient between two consecutive lung function tests performed within 6 mo, over a period of 43 mo on 3,378 miners. There was significant temporal variability in the reliability. For FEV₁, the coefficient G showed increased variability over the first 5 mo and stabilized at a value of 0.93 for the next 23 mo, after which it systematically declined over the next 15 mo. We estimated that in a large screening program, an optimal sample size of around 900 miners, examined randomly throughout the year, on a yearly basis, would provide a sufficient sample to examine monthly or quarterly fluctuation in the reliability. The value of the reliability coefficient G did not change when the time between two consecutive tests increased up to 15 mo. In conclusion, monitoring of lung function reliability in a screening program by the reliability coefficient G should improve data quality, and provide a measure on which the confidence in a decision-making process could be based when examining temporal changes in lung function for individual subjects. Hnizdo E, Churchyard G, Barnes D, Dowdeswell R. Assessment of reliability of lung function screening programs or longitudinal studies.

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