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Am. J. Respir. Crit. Care Med., Volume 160, Number 6, December 1999, 1983-1986

Effects of Dobutamine on Gastric Mucosal Perfusion and Hepatic Metabolism in Patients with Septic Shock

LUC-MARIE JOLY, MEHRAN MONCHI, ALAIN CARIOU, JEAN-DANIEL CHICHE, FLORENCE BELLENFANT, FABRICE BRUNET, and JEAN-FRANÇOIS DHAINAUT

Medical Intensive Care Unit, Cochin Port Royal University Hospital, Paris, France

We prospectively evaluated the effects of dobutamine on gastric mucosal perfusion and hepatocytic clearance in patients with septic shock. After resuscitation with volume expansion and norepinephrine (12 patients) as needed, 14 hemodynamically stable patients (median age: 60 yr, median SAPS II score: 47) were given an infusion of 7.5 µg/kg/min dobutamine for 1 h. Gastric mucosal perfusion and hepatocytic clearance were assessed with tonometry and indocyanine green (ICG) elimination, respectively. All measurements were made before dobutamine infusion, after 1 h of dobutamine infusion, and 1 h after the infusion ended. Cardiac output (thermodilution technique) increased with dobutamine from a baseline median level of 4.0 L/min/m2 (range: 1.7 to 7.4 L/min/m2) to 5.0 L/min/m2 (range: 3.5 to 8.9 L/min/m2) (p = 0.004) and returned to baseline levels after dobutamine infusion ended. The gastric-arterial PCO2 difference decreased from a baseline median level of 13 mm Hg (range: 5 to 54 mm Hg) to 7 mm Hg (range: 5 to 48 mm Hg) (p = 0.005). ICG elimination was low in all patients at baseline (median plasma disappearance rate: 12.2%; range: 7.6 to 16.2%) and did not change significantly during or after dobutamine infusion. In summary, dobutamine increases gastric mucosal perfusion but does not alter hepatocytic clearance in patients with septic shock. The absence of a beneficial effect of dobutamine on hepatocytic clearance may be related to profound alterations in hepatocellular metabolism during septic shock. Joly L-M, Monchi M, Cariou A, Chiche J-D, Bellenfant F, Brunet F, Dhainaut J-F. Effects of dobutamine on gastric mucosal perfusion and hepatic metabolism in patients with septic shock.




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