help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CULPITT, S. V.
Right arrow Articles by BARNES, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CULPITT, S. V.
Right arrow Articles by BARNES, P. J.

Am. J. Respir. Crit. Care Med., Volume 160, Number 5, November 1999, 1635-1639

Effect of High Dose Inhaled Steroid on Cells, Cytokines, and Proteases in Induced Sputum in Chronic Obstructive Pulmonary Disease

SARAH V. CULPITT, WASIM MAZIAK, STELIOS LOUKIDIS, JULIA A. NIGHTINGALE, JOHN L. MATTHEWS, and PETER J. BARNES

Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London; and Respiratory Diseases Unit, Glaxo Wellcome, Stevenage, United Kingdom

Inhaled corticosteroids are widely prescribed for the treatment of stable chronic obstructive pulmonary disease (COPD), despite lack of proven efficacy. Because COPD involves airway inflammation and probable protease-antiprotease imbalance, we examined the effect of high dose fluticasone propionate on markers of activity of both pathogenetic mechanisms. Thirteen patients with COPD were treated with fluticasone propionate (500 µg twice a day) for 4 wk, delivered via MDI and spacer, in a double-blind crossover study. There was no clinical benefit in terms of lung function or symptom scores, and induced sputum inflammatory cells, percentage neutrophils, and IL-8 levels were unchanged. Sputum supernatant elastase activity, matrix metalloproteinase (MMP)-1, MMP-9, and the antiproteases secretory leukoprotease inhibitor (SLPI) and tissue inhibitor of metalloproteinase (TIMP)-1 were similarly unaffected by treatment. These results add to previous evidence that inhaled steroids have no anti-inflammatory action in stable COPD. Furthermore, inhaled steroids do not appear to redress the protease-antiprotease imbalance that is thought to be important in the pathogenesis of airway obstruction. Culpitt SV, Maziak W, Loukidis S, Nightingale JA, Matthews JL, Barnes PJ. Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease.




This article has been cited by other articles:


Home page
 Eur Respir JHome page
S. Suissa and P. J. Barnes
Inhaled corticosteroids in COPD: the case against
Eur. Respir. J., July 1, 2009; 34(1): 13 - 16.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
D-W. Perng, C-W. Tao, K-C. Su, C-C. Tsai, L-Y. Liu, and Y-C. Lee
Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD
Eur. Respir. J., April 1, 2009; 33(4): 778 - 784.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. K. Meja, S. Rajendrasozhan, D. Adenuga, S. K. Biswas, I. K. Sundar, G. Spooner, J. A. Marwick, P. Chakravarty, D. Fletcher, P. Whittaker, et al.
Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2
Am. J. Respir. Cell Mol. Biol., September 1, 2008; 39(3): 312 - 323.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. F. Chung and I. M. Adcock
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Eur. Respir. J., June 1, 2008; 31(6): 1334 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
V. Kim, T. J. Rogers, and G. J. Criner
New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, May 1, 2008; 5(4): 478 - 485.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al.
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Eur. Respir. J., February 1, 2008; 31(2): 416 - 469.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Costa, R. Rufino, S. L. Traves, J. R. Lapa e Silva, P. J. Barnes, and L. E. Donnelly
CXCR3 and CCR5 Chemokines in Induced Sputum From Patients With COPD
Chest, January 1, 2008; 133(1): 26 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. J. Powrie, T. M. A. Wilkinson, G. C. Donaldson, P. Jones, K. Scrine, K. Viel, S. Kesten, and J. A. Wedzicha
Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD
Eur. Respir. J., September 1, 2007; 30(3): 472 - 478.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Ernst, A. V. Gonzalez, P. Brassard, and S. Suissa
Inhaled Corticosteroid Use in Chronic Obstructive Pulmonary Disease and the Risk of Hospitalization for Pneumonia
Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 162 - 166.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
F. Komatsu, H. Kudoh, and Y. Kagawa
Evaluation of Oxidative Stress and Effectiveness of Low-Dose Glucocorticoid Therapy on Exacerbation of Chronic Obstructive Pulmonary Disease
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2007; 62(4): 459 - 464.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. Paredi, S. Ward, D. Cramer, P. J. Barnes, and S. A. Kharitonov
Normal Bronchial Blood Flow in COPD Is Unaffected by Inhaled Corticosteroids and Correlates With Exhaled Nitric Oxide
Chest, April 1, 2007; 131(4): 1075 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Tao, J. Lan, G. L. Lukacs, R. J. G. Hache, and F. Kaplan
Importin 13 Regulates Nuclear Import of the Glucocorticoid Receptor in Airway Epithelial Cells
Am. J. Respir. Cell Mol. Biol., December 1, 2006; 35(6): 668 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes
Against the dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases.
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 240 - 243.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Rahman and I. M. Adcock
Oxidative stress and redox regulation of lung inflammation in COPD.
Eur. Respir. J., July 1, 2006; 28(1): 219 - 242.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes, B. Chowdhury, S. A. Kharitonov, H. Magnussen, C. P. Page, D. Postma, and M. Saetta
Pulmonary Biomarkers in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 1, 2006; 174(1): 6 - 14.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
O. Leclerc, V. Lagente, J-M. Planquois, C. Berthelier, M. Artola, T. Eichholtz, C. P. Bertrand, and F. Schmidlin
Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice
Eur. Respir. J., June 1, 2006; 27(6): 1102 - 1109.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M A Dentener, R Louis, R H E Cloots, M Henket, and E F M Wouters
Differences in local versus systemic TNF{alpha} production in COPD: inhibitory effect of hyaluronan on LPS induced blood cell TNF{alpha} release
Thorax, June 1, 2006; 61(6): 478 - 484.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. F. M. Wouters
Approaches to Improving Health Status in Chronic Obstructive Pulmonary Disease: One or Several?
Proceedings of the ATS, May 1, 2006; 3(3): 262 - 269.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Bergeron and L.-P. Boulet
Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation.
Chest, April 1, 2006; 129(4): 1068 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L.-P. Boulet, C. Lemiere, F. Archambault, G. Carrier, M. C. Descary, and F. Deschesnes
Smoking and Asthma: Clinical and Radiologic Features, Lung Function, and Airway Inflammation
Chest, March 1, 2006; 129(3): 661 - 668.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. J. Barnes
Corticosteroid effects on cell signalling
Eur. Respir. J., February 1, 2006; 27(2): 413 - 426.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. J. Barnes
Reduced Histone Deacetylase in COPD: Clinical Implications
Chest, January 1, 2006; 129(1): 151 - 155.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
D D Sin, L Wu, J A Anderson, N R Anthonisen, A S Buist, P S Burge, P M Calverley, J E Connett, B Lindmark, R A Pauwels, et al.
Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease
Thorax, December 1, 2005; 60(12): 992 - 997.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
W. MacNee
Pathogenesis of Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, November 1, 2005; 2(4): 258 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
I. M. Adcock and K. Ito
Glucocorticoid Pathways in Chronic Obstructive Pulmonary Disease Therapy
Proceedings of the ATS, November 1, 2005; 2(4): 313 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. J. Barnes
Theophylline in Chronic Obstructive Pulmonary Disease: New Horizons
Proceedings of the ATS, November 1, 2005; 2(4): 334 - 339.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. A. Martorana, R. Beume, M. Lucattelli, L. Wollin, and G. Lungarella
Roflumilast Fully Prevents Emphysema in Mice Chronically Exposed to Cigarette Smoke
Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 848 - 853.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. A. Birrell, S. Wong, D. J. Hele, K. McCluskie, E. Hardaker, and M. G. Belvisi
Steroid-resistant Inflammation in a Rat Model of Chronic Obstructive Pulmonary Disease Is Associated with a Lack of Nuclear Factor-{kappa}B Pathway Activation
Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 74 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. J. Barnes and R. A. Stockley
COPD: current therapeutic interventions and future approaches
Eur. Respir. J., June 1, 2005; 25(6): 1084 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. de Garavilla, M. N. Greco, N. Sukumar, Z.-W. Chen, A. O. Pineda, F. S. Mathews, E. Di Cera, E. C. Giardino, G. I. Wells, B. J. Haertlein, et al.
A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase: MOLECULAR MECHANISMS AND ANTI-INFLAMMATORY ACTIVITY IN VIVO
J. Biol. Chem., May 6, 2005; 280(18): 18001 - 18007.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. F. P. Man and D. D. Sin
Effects of Corticosteroids on Systemic Inflammation in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2005; 2(1): 78 - 82.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Alvarez-Mon, M. Miravitlles, J. Morera, L. Callol, and J. L. Alvarez-Sala
Treatment With the Immunomodulator AM3 Improves the Health-Related Quality of Life of Patients With COPD
Chest, April 1, 2005; 127(4): 1212 - 1218.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. J. Barnes, I. M. Adcock, and K. Ito
Histone acetylation and deacetylation: importance in inflammatory lung diseases
Eur. Respir. J., March 1, 2005; 25(3): 552 - 563.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
C E Brightling, S McKenna, B Hargadon, S Birring, R Green, R Siva, M Berry, D Parker, W Monteiro, I D Pavord, et al.
Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease
Thorax, March 1, 2005; 60(3): 193 - 198.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Linden, M. Laan, and G. P. Anderson
Neutrophils, interleukin-17A and lung disease
Eur. Respir. J., January 1, 2005; 25(1): 159 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
P. J. Barnes
Mediators of Chronic Obstructive Pulmonary Disease
Pharmacol. Rev., December 1, 2004; 56(4): 515 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. Chanez, A. Bourdin, I. Vachier, P. Godard, J. Bousquet, and A. M. Vignola
Effects of Inhaled Corticosteroids on Pathology in Asthma and Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, November 1, 2004; 1(3): 184 - 190.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. G. Belvisi
Regulation of Inflammatory Cell Function by Corticosteroids
Proceedings of the ATS, November 1, 2004; 1(3): 207 - 214.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. P. Schleimer
Glucocorticoids Suppress Inflammation but Spare Innate Immune Responses in Airway Epithelium
Proceedings of the ATS, November 1, 2004; 1(3): 222 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
I. M. Adcock, K. Ito, and P. J. Barnes
Glucocorticoids: Effects on Gene Transcription
Proceedings of the ATS, November 1, 2004; 1(3): 247 - 254.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. J. Barnes
Corticosteroid Resistance in Airway Disease
Proceedings of the ATS, November 1, 2004; 1(3): 264 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. D. Sin, P. Lacy, E. York, and S. F. P. Man
Effects of Fluticasone on Systemic Markers of Inflammation in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 760 - 765.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Lam, J. C. leRiche, A. McWilliams, C. MacAulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, et al.
A Randomized Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) in People with Dysplasia of the Bronchial Epithelium
Clin. Cancer Res., October 1, 2004; 10(19): 6502 - 6511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. E. Donnelly, R. Newton, G. E. Kennedy, P. S. Fenwick, R. H. F. Leung, K. Ito, R. E. K. Russell, and P. J. Barnes
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms
Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L774 - L783.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Barczyk, E. Sozanska, M. Trzaska, and W. Pierzchala
Decreased Levels of Myeloperoxidase in Induced Sputum of Patients With COPD After Treatment With Oral Glucocorticoids
Chest, August 1, 2004; 126(2): 389 - 393.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. L. Traves, S. J. Smith, P. J. Barnes, and L. E. Donnelly
Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2
J. Leukoc. Biol., August 1, 2004; 76(2): 441 - 450.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. W. Mapel
Treatment Implications on Morbidity and Mortality in COPD
Chest, August 1, 2004; 126(2_suppl_1): 150S - 158S.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Cazzola and R. Dahl
Inhaled Combination Therapy With Long-Acting {beta}2-Agonists and Corticosteroids in Stable COPD
Chest, July 1, 2004; 126(1): 220 - 237.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. Banerjee, O.A. Khair, and D. Honeybourne
Impact of sputum bacteria on airway inflammation and health status in clinical stable COPD
Eur. Respir. J., May 1, 2004; 23(5): 685 - 691.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M.N. de Melo, P. Ernst, and S. Suissa
Inhaled corticosteroids and the risk of a first exacerbation in COPD patients
Eur. Respir. J., May 1, 2004; 23(5): 692 - 697.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.N.R. Dekhuijzen
Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease
Eur. Respir. J., April 1, 2004; 23(4): 629 - 636.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. D. Sin, F. A. McAlister, S. F. P. Man, and N. R. Anthonisen
Contemporary Management of Chronic Obstructive Pulmonary Disease: Scientific Review
JAMA, November 5, 2003; 290(17): 2301 - 2312.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E{-}J.D. Oudijk, J{-}W.J. Lammers, and L. Koenderman
Systemic inflammation in chronic obstructive pulmonary disease
Eur. Respir. J., November 2, 2003; 22(46_suppl): 5s - 13s.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
E R Sutherland, H Allmers, N T Ayas, A J Venn, and R J Martin
Inhaled corticosteroids reduce the progression of airflow limitation in chronic obstructive pulmonary disease: a meta-analysis
Thorax, November 1, 2003; 58(11): 937 - 941.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Gamble, D. C. Grootendorst, C. E. Brightling, S. Troy, Y. Qiu, J. Zhu, D. Parker, D. Matin, S. Majumdar, A. M. Vignola, et al.
Antiinflammatory Effects of the Phosphodiesterase-4 Inhibitor Cilomilast (Ariflo) in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 976 - 982.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.J. Barnes, S.D. Shapiro, and R.A. Pauwels
Chronic obstructive pulmonary disease: molecular and cellularmechanisms
Eur. Respir. J., October 1, 2003; 22(4): 672 - 688.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. Kostikas, G. Papatheodorou, K. Psathakis, P. Panagou, and S. Loukides
Oxidative Stress in Expired Breath Condensate of Patients With COPD
Chest, October 1, 2003; 124(4): 1373 - 1380.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
P. J. Barnes and I. M. Adcock
How Do Corticosteroids Work in Asthma?
Ann Intern Med, September 2, 2003; 139(5_Part_1): 359 - 370.
[Full Text] [PDF]

Home page
 ChestHome page
N. A. Hanania, P. Darken, D. Horstman, C. Reisner, B. Lee, S. Davis, and T. Shah
The Efficacy and Safety of Fluticasone Propionate (250 {micro}g)/Salmeterol (50 {micro}g) Combined in the Diskus Inhaler for the Treatment of COPD
Chest, September 1, 2003; 124(3): 834 - 843.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. Suki, K. R. Lutchen, and E. P. Ingenito
On the Progressive Nature of Emphysema: Roles of Proteases, Inflammation, and Mechanical Forces
Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 516 - 521.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
The pharmacoepidemiology of COPD: Recent advances and methodological discussion
Eur. Respir. J., September 1, 2003; 22(43_suppl): 1s - 44s.
[Full Text] [PDF]

Home page
 ThoraxHome page
P J Barnes
Chronic obstructive pulmonary disease * 12: New treatments for COPD
Thorax, September 1, 2003; 58(9): 803 - 808.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Bourbeau, P. Ernst, D. Cockcoft, and S. Suissa
Inhaled corticosteroids and hospitalisation due to exacerbation of COPD
Eur. Respir. J., August 1, 2003; 22(2): 286 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R.O. Crapo, R.L. Jensen, and F.E. Hargreave
Airway inflammation in COPD: physiological outcome measures and induced sputum
Eur. Respir. J., June 1, 2003; 21(41_suppl): 19S - 28s.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Escotte, O. Tabary, D. Dusser, C. Majer-Teboul, E. Puchelle, and J. Jacquot
Fluticasone reduces IL-6 and IL-8 production of cystic fibrosis bronchial epithelial cells via IKK-{beta} kinase pathway
Eur. Respir. J., April 1, 2003; 21(4): 574 - 581.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.G. Gibson, P.A.B. Wark, J.L. Simpson, C. Meldrum, S. Meldrum, N. Saltos, and M. Boyle
Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis
Eur. Respir. J., April 1, 2003; 21(4): 582 - 588.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. Domagala-Kulawik, M. Maskey-Warzechowska, I. Kraszewska, and R. Chazan
The Cellular Composition and Macrophage Phenotype in Induced Sputum in Smokers and Ex-Smokers With COPD
Chest, April 1, 2003; 123(4): 1054 - 1059.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. M. Beeh, O. Kornmann, R. Buhl, S. V. Culpitt, M. A. Giembycz, and P. J. Barnes
Neutrophil Chemotactic Activity of Sputum From Patients With COPD: Role of Interleukin 8 and Leukotriene B4
Chest, April 1, 2003; 123(4): 1240 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes
Theophylline: New Perspectives for an Old Drug
Am. J. Respir. Crit. Care Med., March 15, 2003; 167(6): 813 - 818.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Paredi, G. Caramori, D. Cramer, S. Ward, A. Ciaccia, A. Papi, S.A. Kharitonov, and P.J. Barnes
Slower rise of exhaled breath temperature in chronic obstructive pulmonary disease
Eur. Respir. J., March 1, 2003; 21(3): 439 - 443.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H. Garn, A. Siese, S. Stumpf, P. J. Barth, B. Muller, and D. Gemsa
Shift Toward an Alternatively Activated Macrophage Response in Lungs of NO2-Exposed Rats
Am. J. Respir. Cell Mol. Biol., March 1, 2003; 28(3): 386 - 396.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. M. Beeh, J. Beier, O. Kornmann, A. Mander, and R. Buhl
Long-term Repeatability of Induced Sputum Cells and Inflammatory Markers in Stable, Moderately Severe COPD
Chest, March 1, 2003; 123(3): 778 - 783.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D.D. Sin and S.F.P. Man
Inhaled corticosteroids and survival in chronic obstructive pulmonary disease: does the dose matter?
Eur. Respir. J., February 1, 2003; 21(2): 260 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. V. Culpitt, D. F. Rogers, P. Shah, C. De Matos, R. E. K. Russell, L. E. Donnelly, and P. J. Barnes
Impaired Inhibition by Dexamethasone of Cytokine Release by Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., January 1, 2003; 167(1): 24 - 31.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S L Traves, S V Culpitt, R E K Russell, P J Barnes, and L E Donnelly
Increased levels of the chemokines GRO{alpha} and MCP-1 in sputum samples from patients with COPD
Thorax, July 1, 2002; 57(7): 590 - 595.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
Leader of the Working Group: M.M. Kelly, Members of the Working Group:, V. Keatings, R. Leigh, C. Peterson, J. Shute, P. Venge, and R. Djukanovic
Analysis of fluid{-}phase mediators
Eur. Respir. J., July 1, 2002; 20(37_suppl): 24S - 39s.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. V. Culpitt, C. de Matos, R. E. Russell, L. E. Donnelly, D. F. Rogers, and P. J. Barnes
Effect of Theophylline on Induced Sputum Inflammatory Indices and Neutrophil Chemotaxis in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., May 15, 2002; 165(10): 1371 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. Sturton and M. Fitzgerald
Phosphodiesterase 4 Inhibitors for the Treatment of COPD*
Chest, May 1, 2002; 121(5_suppl): 192S - 196S.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
W. I. de Boer
Cytokines and Therapy in COPD* : A Promising Combination?
Chest, May 1, 2002; 121(5_suppl): 209S - 218S.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. E. Silkoff, D. Martin, J. Pak, J. Y. Westcott, and R. J. Martin
Exhaled Nitric Oxide Correlated With Induced Sputum Findings in COPD
Chest, April 1, 2001; 119(4): 1049 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. PILETTE, V. GODDING, R. KISS, M. DELOS, E. VERBEKEN, C. DECAESTECKER, K. DE PAEPE, J.-P. VAERMAN, M. DECRAMER, and Y. SIBILLE
Reduced Epithelial Expression of Secretory Component in Small Airways Correlates with Airflow Obstruction in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 185 - 194.
[Abstract] [Full Text]

Home page
 ThoraxHome page
A. Hill, S. Gompertz, and R. Stockley
Factors influencing airway inflammation in chronic obstructive pulmonary disease
Thorax, November 1, 2000; 55(11): 970 - 977.
[Full Text]

Home page
 NEJMHome page
P. J. Barnes
Chronic Obstructive Pulmonary Disease
N. Engl. J. Med., July 27, 2000; 343(4): 269 - 280.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. BARNES
Inhaled Corticosteroids Are Not Beneficial in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): 342 - 344.
[Full Text]

Home page
 ChestHome page
P. J. Barnes
Mechanisms in COPD : Differences From Asthma
Chest, February 1, 2000; 117(2_suppl): 10S - 14S.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society 		  Tobacco