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Am. J. Respir. Crit. Care Med., Volume 160, Number 2, August 1999, 711-717

CD8+ve Cells in the Lungs of Smokers with Chronic Obstructive Pulmonary Disease

MARINA SAETTA, SIMONETTA BARALDO, LAURA CORBINO, GRAZIELLA TURATO, FAUSTO BRACCIONI, FEDERICO REA, GIORGIO CAVALLESCO, GIUSEPPE TROPEANO, CRISTINA E. MAPP, PIERO MAESTRELLI, ADALBERTO CIACCIA, and LEONARDO M. FABBRI

Institute of Occupational Medicine and Department of Thoracic Surgery, University of Padova, Padova; and Institute of Respiratory Diseases and Department of Surgical Pathology, University of Ferrara, Ferrara, Italy

Previous studies have shown an increased number of inflammatory cells and, in particular, CD8+ve cells in the airways of smokers with chronic obstructive pulmonary disease (COPD). In this study we investigated whether a similar inflammatory process is also present in the lungs, and particularly in lung parenchyma and pulmonary arteries. We examined surgical specimens from three groups of subjects undergoing lung resection for localized pulmonary lesions: nonsmokers (n = 8), asymptomatic smokers with normal lung function (n = 6), and smokers with COPD (n = 10). Alveolar walls and pulmonary arteries were examined with immunohistochemical methods to identify neutrophils, eosinophils, mast cells, macrophages, and CD4+ve and CD8+ve cells. Smokers with COPD had an increased number of CD8+ve cells in both lung parenchyma (p < 0.05) and pulmonary arteries (p < 0.001) as compared with nonsmokers. CD8+ve cells were also increased in pulmonary arteries of smokers with COPD as compared with smokers with normal lung function (p < 0.01). Other inflammatory cells were no different among the three groups. The number of CD8+ve cells in both lung parenchyma and pulmonary arteries was significantly correlated with the degree of airflow limitation in smokers. These results show that an inflammatory process similar to that present in the conducting airways is also present in lung parenchyma and pulmonary arteries of smokers with COPD.




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