help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HOPKINS, R. O.
Right arrow Articles by LARSON-LOHR, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HOPKINS, R. O.
Right arrow Articles by LARSON-LOHR, V.

Am. J. Respir. Crit. Care Med., Volume 160, Number 1, July 1999, 50-56

Neuropsychological Sequelae and Impaired Health Status in Survivors of Severe Acute Respiratory Distress Syndrome

RAMONA O. HOPKINS, LINDELL K. WEAVER, DONNA POPE, JAMES F. ORME Jr., ERIN D. BIGLER, and VALERIE LARSON-LOHR

Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City; Division of Respiratory, Critical Care, and Occupational (Pulmonary) Medicine, University of Utah School of Medicine, Salt Lake City; and Department of Psychology, Brigham Young University, Provo, Utah

Acute respiratory distress syndrome (ARDS) is a disease of acute respiratory failure manifested by severe hypoxemia with a high mortality rate. Previous outcome studies of ARDS have assessed survival and/or pulmonary function as the primary outcome variables. Cognitive or psychological outcomes following ARDS have not been described, despite the possibility that ARDS patients are at risk for brain injury through hypoxemia or other mechanisms. In the current study 55 consecutive ARDS survivors completed a battery of neuropsychological tests and questionnaires regarding health status, cognitive and psychological outcomes at the time of hospital discharge and 1 yr after onset of ARDS. At hospital discharge, 100% (55 of 55) of survivors exhibited cognitive and affective impairments, as well as problems with health status which affected their quality of life. At 1 yr after ARDS, 17 of 55 (30%) patients still exhibited generalized cognitive decline. Forty-three of 55 (78%) patients had all or at least one of the following: impaired memory, attention, concentration and/or decreased mental processing speed. One year after ARDS a substantial portion of ARDS survivors exhibit impaired health status and cognitive sequelae which may be due to hypoxemia, emboli, inflammation, drug toxicity, and/or other etiologies.




This article has been cited by other articles:


Home page
 J Intensive Care MedHome page
M. A. Pisani
Analytic Reviews: Considerations in Caring for the Critically Ill Older Patient
J Intensive Care Med, March 1, 2009; 24(2): 83 - 95.
[Abstract] [PDF]

Home page
 ChestHome page
N. K. J. Adhikari, M. P. McAndrews, C. M. Tansey, A. Matte, R. Pinto, A. M. Cheung, N. Diaz-Granados, A. Barr, and M. S. Herridge
Self-Reported Symptoms of Depression and Memory Dysfunction in Survivors of ARDS
Chest, March 1, 2009; 135(3): 678 - 687.
[Abstract] [Full Text] [PDF]

Home page
 Psychosom. Med.Home page
D. S. Davydow, S. V. Desai, D. M. Needham, and O. J. Bienvenu
Psychiatric Morbidity in Survivors of the Acute Respiratory Distress Syndrome: A Systematic Review
Psychosom Med, May 1, 2008; 70(4): 512 - 519.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. T. Pun and E. W. Ely
The Importance of Diagnosing and Managing ICU Delirium
Chest, August 1, 2007; 132(2): 624 - 636.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
A. C. Gray, L. Torrens, T. O. White, A. Carson, and C. M. Robinson
The Cognitive Effects of Fat Embolus Syndrome Following an Isolated Femoral Shaft Fracture. A Case Report
J. Bone Joint Surg. Am., May 1, 2007; 89(5): 1092 - 1096.
[Full Text] [PDF]

Home page
 TraumaHome page
J. Carr
Psychological consequences associated with intensive care treatment
Trauma, April 1, 2007; 9(2): 95 - 102.
[Abstract] [PDF]

Home page
 ChestHome page
G. D. Rubenfeld and M. S. Herridge
Epidemiology and Outcomes of Acute Lung Injury
Chest, February 1, 2007; 131(2): 554 - 562.
[Abstract] [Full Text] [PDF]

Home page
 PsychosomaticsHome page
C. Weinert and W. Meller
Epidemiology of Depression and Antidepressant Therapy After Acute Respiratory Failure
Psychosomatics, October 1, 2006; 47(5): 399 - 407.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. O. Hopkins and J. C. Jackson
Long-term Neurocognitive Function After Critical Illness.
Chest, September 1, 2006; 130(3): 869 - 878.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
E. Fan, D. M. Needham, and T. E. Stewart
Ventilatory Management of Acute Lung Injury and Acute Respiratory Distress Syndrome
JAMA, December 14, 2005; 294(22): 2889 - 2896.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. S. Herridge and D. C. Angus
Acute lung injury--affecting many lives.
N. Engl. J. Med., October 20, 2005; 353(16): 1736 - 1738.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. R. Bernard
Acute Respiratory Distress Syndrome: A Historical Perspective
Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 798 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Lin, H. Yang, T. Sakuragi, M. Hu, L. L. Mantell, S. Hayashi, Y. Al-Abed, K. J. Tracey, L. Ulloa, and E. J. Miller
{alpha}-Chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis
Am J Physiol Lung Cell Mol Physiol, October 1, 2005; 289(4): L583 - L590.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Garland
Improving the ICU: Part 1
Chest, June 1, 2005; 127(6): 2151 - 2164.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. R. Thom, L. K. Weaver, and N. B. Hampson
"Therapeutic" Carbon Monoxide May Be Toxic
Am. J. Respir. Crit. Care Med., June 1, 2005; 171(11): 1318 - 1318.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. O. Hopkins, L. K. Weaver, D. Collingridge, R. B. Parkinson, K. J. Chan, and J. F. Orme Jr.
Two-Year Cognitive, Emotional, and Quality-of-Life Outcomes in Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., February 15, 2005; 171(4): 340 - 347.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Garland, N. V. Dawson, I. Altmann, C. L. Thomas, R. S. Phillips, J. Tsevat, N. A. Desbiens, P. E. Bellamy, W. A. Knaus, A. F. Connors Jr, et al.
Outcomes up to 5 Years After Severe, Acute Respiratory Failure
Chest, December 1, 2004; 126(6): 1897 - 1904.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
E. W. Ely, A. Shintani, B. Truman, T. Speroff, S. M. Gordon, F. E. Harrell Jr, S. K. Inouye, G. R. Bernard, and R. S. Dittus
Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
JAMA, April 14, 2004; 291(14): 1753 - 1762.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. P. Kress, B. Gehlbach, M. Lacy, N. Pliskin, A. S. Pohlman, and J. B. Hall
The Long-term Psychological Effects of Daily Sedative Interruption on Critically Ill Patients
Am. J. Respir. Crit. Care Med., December 15, 2003; 168(12): 1457 - 1461.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. M. Browne, P. W. Halligan, D. T. Wade, and D. P. Taggart
Postoperative hypoxia is a contributory factor to cognitive impairment after cardiac surgery
J. Thorac. Cardiovasc. Surg., October 1, 2003; 126(4): 1061 - 1064.
[Abstract] [Full Text] [PDF]

Home page
 Crit Care NurseHome page
B. Truman and E. W. Ely
Monitoring Delirium in Critically Ill Patients: Using the Confusion Assessment Method for the Intensive Care Unit
Crit. Care Nurse, April 1, 2003; 23(2): 25 - 35.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Orme Jr., J. S. Romney, R. O. Hopkins, D. Pope, K. J. Chan, G. Thomsen, R. O. Crapo, and L. K. Weaver
Pulmonary Function and Health-related Quality of Life in Survivors of Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 690 - 694.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. S. Herridge, A. M. Cheung, C. M. Tansey, A. Matte-Martyn, N. Diaz-Granados, F. Al-Saidi, A. B. Cooper, C. B. Guest, C. D. Mazer, S. Mehta, et al.
One-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome
N. Engl. J. Med., February 20, 2003; 348(8): 683 - 693.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
L. D. Hudson and C. M. Lee
Neuromuscular Sequelae of Critical Illness
N. Engl. J. Med., February 20, 2003; 348(8): 745 - 747.
[Full Text] [PDF]

Home page
 TraumaHome page
L Tomlinson and G. Bellingan
Trauma and acute lung injury
Trauma, July 1, 2002; 4(3): 147 - 157.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
E. W. Ely, A. P. Wheeler, B. T. Thompson, M. Ancukiewicz, K. P. Steinberg, G. R. Bernard, and for the Acute Respiratory Distress Syndrome Networ
Recovery Rate and Prognosis in Older Persons Who Develop Acute Lung Injury and the Acute Respiratory Distress Syndrome
Ann Intern Med, January 1, 2002; 136(1): 25 - 36.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
E. W. Ely, S. K. Inouye, G. R. Bernard, S. Gordon, J. Francis, L. May, B. Truman, T. Speroff, S. Gautam, R. Margolin, et al.
Delirium in Mechanically Ventilated Patients: Validity and Reliability of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
JAMA, December 5, 2001; 286(21): 2703 - 2710.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. C. ANGUS, A. A. MUSTHAFA, G. CLERMONT, M. F. GRIFFIN, W. T. LINDE-ZWIRBLE, T. T. DREMSIZOV, and M. R. PINSKY
Quality-adjusted Survival in the First Year after the Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., May 1, 2001; 163(6): 1389 - 1394.
[Abstract] [Full Text]

Home page
 NEJMHome page
A. Jaffe, W. M. Landau, R. D. Wetzel, W. J. Groh, M. E. Salive, L. D. Richardson, The Public Access Defibrillation Trial Investigato, R. E. Fried, M. Bassan, T. D. Valenzuela, et al.
Automated External Defibrillators
N. Engl. J. Med., March 8, 2001; 344(10): 771 - 773.
[Full Text] [PDF]

Home page
 ChestHome page
C. R. Weinert
Epidemiology of Psychiatric Medication Use in Patients Recovering From Critical Illness at a Long-term Acute-Care Facility
Chest, February 1, 2001; 119(2): 547 - 553.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society 		  Tobacco