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Am. J. Respir. Crit. Care Med., Volume 160, Number 1, July 1999, 349-353

Acute Purulent Exacerbation of Chronic Obstructive Pulmonary Disease and Chlamydia pneumoniae Infection

NESRIN MOGULKOC, SAIT KARAKURT, BARBARA ISALSKA, ÜLKÜ BAYINDIR, TURGAY ÇELIKEL, VOLKAN KORTEN, and NESRIN ÇOLPAN

Departments of Respiratory Medicine and Microbiology, Ege University Hospital, Izmir; Departments of Respiratory and Critical Care Medicine and Infectious Diseases, Marmara University Hospital, Istanbul, Turkey; and Microbiology Department, Wythenshawe Hospital, Manchester, United Kingdom

In order to investigate the role of bacteria, including Mycoplasma pneumoniae and especially Chlamydia pneumoniae in acute purulent exacerbations of chronic obstructive pulmonary disease (COPD), we examined sputum specimens and acute and convalescent sera taken 26 d apart from 49 outpatients experiencing an acute purulent exacerbation of COPD. The sera were tested for antibodies to C. pneumoniae with the microimmunofluorescence test, and for antibodies to M. pneumoniae with the indirect fluorescence antibody test. Routine microbiologic culture of sputum yielded potentially pathogenic microorganisms in 12 of the 49 patients (24%). Three patients (6%) showed serologic evidence of recent M. pneumoniae infection. Seven patients showed high IgG titers of >=  1:1,024 to C. pneumoniae, and an additional four had a fourfold increase in IgG titer, suggesting reinfection with C. pneumoniae. Sputum from two of these 11 patients also grew Streptococcus pneumoniae, and one grew Moraxella catarrhalis. Patients with and without serologic evidence of current C. pneumoniae infection showed no significant differences in clinical features or pulmonary function. The high incidence of infection with C. pneumoniae (the sole causal agent in 16% of cases, and the causal agent with other agents in 6%) provides insight into the importance of this organism among agents leading to exacerbations of COPD in Turkey.




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