help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by IIJIMA, H.
Right arrow Articles by SHIRATO, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by IIJIMA, H.
Right arrow Articles by SHIRATO, K.

Am. J. Respir. Crit. Care Med., Volume 160, Number 1, July 1999, 331-335

Suplatast Tosilate Inhibits Late Response and Airway Inflammation in Sensitized Guinea Pigs

HIDEYA IIJIMA, GEN TAMURA, TZUEN-REN HSIUE, YI LIU, HAJIME TANIGUCHI, and KUNIO SHIRATO

First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan

The effect of suplatast tosilate, which has been proven to inhibit T-cell synthesis of IL-4 and IL-5, on the response to antigen inhalation challenge was investigated in sensitized guinea pigs. The animals were given an oral dose of 30 or 100 mg/kg of suplatast or vehicle (distilled water) daily for 1 wk before antigen challenge. Measurement of pulmonary resistance for 6 h was followed by bronchoalveolar lavage and lung fixation. After antigen challenge, all guinea pigs in the vehicle group displayed dual-phase airway obstruction and accumulation of eosinophils and lymphocytes in the airways. After 1 wk of treatment with the high dose of suplatast, the late asthmatic response and the recruitment of eosinophils and lymphocytes into the airways were significantly inhibited, but the early asthmatic response was not affected. In situ hybridization revealed that challenge-induced increases in IL-5 mRNA-positive cells in lung tissue were significantly inhibited after treatment. Thus, suplatast inhibited airway obstruction in the late phase by specifically inhibiting the inflammatory process after mast cell degranulation.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Shahriar, H. Mizuguchi, K. Maeyama, Y. Kitamura, N. Orimoto, S. Horio, H. Umehara, M. Hattori, N. Takeda, and H. Fukui
Suplatast Tosilate Inhibits Histamine Signaling by Direct and Indirect Down-Regulation of Histamine H1 Receptor Gene Expression through Suppression of Histidine Decarboxylase and IL-4 Gene Transcriptions
J. Immunol., August 1, 2009; 183(3): 2133 - 2141.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Furonaka, N. Hattori, T. Tanimoto, T. Senoo, N. Ishikawa, K. Fujitaka, Y. Haruta, A. Yokoyama, and N. Kohno
Suplatast Tosilate Prevents Bleomycin-Induced Pulmonary Fibrosis in Mice
J. Pharmacol. Exp. Ther., January 1, 2009; 328(1): 55 - 61.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
Y. Liu, G. Tamura, H. Iijima, H. Taniguchi, T. Kikuchi, Y. Ohkawara, and K. Shirato
Effect of whole-body x-irradiation on antigen-induced airway response in sensitized guinea pigs
Eur. Respir. J., April 1, 2001; 17(4): 615 - 622.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society 		  SOTA, FL