help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MARTYNOWICZ, M. A.
Right arrow Articles by HUBMAYR, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MARTYNOWICZ, M. A.
Right arrow Articles by HUBMAYR, R. D.

Am. J. Respir. Crit. Care Med., Volume 160, Number 1, July 1999, 250-258

Regional Expansion of Oleic Acid-Injured Lungs

MAREK A. MARTYNOWICZ, THOMAS A. MINOR, BRUCE J. WALTERS, and ROLF D. HUBMAYR

Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota

It has been suggested that dependent regions of an injured lung are collapsed and subject to cyclic reopening and collapse during mechanical ventilation. To test this hypothesis, we measured both temporal and spatial heterogeneity of lobar expansion in oleic acid (OA)-injured dogs. Regional volumes were measured in nine dogs (seven supine and two prone) during closed loop sinusoidal oscillations of the lungs before and after OA injury using the parenchymal marker technique. In contrast to computer tomography, the parenchymal marker technique provides absolute measures of regional tissue dimensions as opposed to relative measures of regional air to liquid content. The experiments generated three major findings: (1) OA injury did not lead to the collapse of dependent lung units at FRC, (2) OA injury did not steepen the vertical gradient in regional lung volumes at FRC, and (3) during sinusoidal oscillation of the OA-injured lungs from FRC, dependent regions did not undergo cyclic reopening and collapse. On the basis of these results, we propose an alternative mechanism for the topographic variability in regional impedances and lung expansion after injury, namely liquid and foam in conducting airways.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
H. C. Yalcin, S. F. Perry, and S. N. Ghadiali
Influence of airway diameter and cell confluence on epithelial cell injury in an in vitro model of airway reopening
J Appl Physiol, November 1, 2007; 103(5): 1796 - 1807.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. Lin, J. Walker, L. Xu, D. Gozal, and J. Yu
Respiratory: Behaviours of pulmonary sensory receptors during development of acute lung injury in the rabbit
Exp Physiol, July 1, 2007; 92(4): 749 - 755.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Tsuchida and B. P. Kavanagh
Ventilator-induced Lung Injury Distribution: The Key to Understanding Injury Mechanisms
Am. J. Respir. Crit. Care Med., January 1, 2007; 175(1): 96 - 96.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. Karmrodt, C. Bletz, S. Yuan, M. David, C.-P. Heussel, and K. Markstaller
Quantification of atelectatic lung volumes in two different porcine models of ARDS
Br. J. Anaesth., December 1, 2006; 97(6): 883 - 895.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
T. Luecke, J. P. Meinhardt, P. Herrmann, A. Weiss, M. Quintel, and P. Pelosi
Oleic Acid vs Saline Solution Lung Lavage-Induced Acute Lung Injury: Effects on Lung Morphology, Pressure-Volume Relationships, and Response to Positive End-Expiratory Pressure.
Chest, August 1, 2006; 130(2): 392 - 401.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Tsuchida, D. Engelberts, V. Peltekova, N. Hopkins, H. Frndova, P. Babyn, C. McKerlie, M. Post, P. McLoughlin, and B. P. Kavanagh
Atelectasis Causes Alveolar Injury in Nonatelectatic Lung Regions
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 279 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
G. Mols, H.-J. Priebe, and J. Guttmann
Alveolar recruitment in acute lung injury
Br. J. Anaesth., February 1, 2006; 96(2): 156 - 166.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
B. A. Simon, G. E. Christensen, D. A. Low, and J. M. Reinhardt
Computed Tomography Studies of Lung Mechanics
Proceedings of the ATS, December 1, 2005; 2(6): 517 - 521.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Naire and O. E. Jensen
Epithelial cell deformation during surfactant-mediated airway reopening: a theoretical model
J Appl Physiol, August 1, 2005; 99(2): 458 - 471.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. B. Allen, L. A. Pavone, J. D. DiRocco, J. H. T. Bates, and G. F. Nieman
Pulmonary impedance and alveolar instability during injurious ventilation in rats
J Appl Physiol, August 1, 2005; 99(2): 723 - 730.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. E. Vlahakis and R. D. Hubmayr
Cellular Stress Failure in Ventilator-injured Lungs
Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1328 - 1342.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. S. A. Cavalcante, S. Ito, K. Brewer, H. Sakai, A. M. Alencar, M. P. Almeida, J. S. Andrade Jr., A. Majumdar, E. P. Ingenito, and B. Suki
Mechanical interactions between collagen and proteoglycans: implications for the stability of lung tissue
J Appl Physiol, February 1, 2005; 98(2): 672 - 679.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. M. Downie, A. J. Nam, and B. A. Simon
Pressure-Volume Curve Does Not Predict Steady-State Lung Volume in Canine Lavage Lung Injury
Am. J. Respir. Crit. Care Med., April 15, 2004; 169(8): 957 - 962.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
E. D. Moloney and M. J. D. Griffiths
Protective ventilation of patients with acute respiratory distress syndrome
Br. J. Anaesth., February 1, 2004; 92(2): 261 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Saumon
Pump and Circumstances
Am. J. Respir. Crit. Care Med., December 15, 2003; 168(12): 1408 - 1409.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
J-D. Ricard, D. Dreyfuss, and G. Saumon
Ventilator-induced lung injury
Eur. Respir. J., August 1, 2003; 22(42_suppl): 2s - 9s.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J-J. Rouby, Q. Lu, and S. Vieira
Pressure/volume curves and lung computed tomography in acute respiratory distress syndrome
Eur. Respir. J., August 1, 2003; 22(42_suppl): 27s - 36s.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
I. de Chazal and R. D. Hubmayr
Novel aspects of pulmonary mechanics in intensive care
Br. J. Anaesth., July 1, 2003; 91(1): 81 - 91.
[Full Text] [PDF]

Home page
 ChestHome page
A. F. Broccard
Prone Position in ARDS: Are We Looking at a Half-Empty or Half-Full Glass?
Chest, May 1, 2003; 123(5): 1334 - 1336.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. E. Baumgardner, K. Markstaller, B. Pfeiffer, M. Doebrich, and C. M. Otto
Effects of Respiratory Rate, Plateau Pressure, and Positive End-Expiratory Pressure on PaO2 Oscillations after Saline Lavage
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1556 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Richard, M. Janier, F. Lavenne, V. Berthier, D. Lebars, G. Annat, F. Decailliot, and C. Guerin
Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury
J Appl Physiol, December 1, 2002; 93(6): 2181 - 2191.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
T Whitehead and A S Slutsky
The pulmonary physician in critical care * 7: Ventilator induced lung injury
Thorax, July 1, 2002; 57(7): 635 - 642.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. D. Hubmayr
Perspective on Lung Injury and Recruitment: A Skeptical Look at the Opening and Collapse Story
Am. J. Respir. Crit. Care Med., June 15, 2002; 165(12): 1647 - 1653.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. J. ROUBY, Q. LU, and I. GOLDSTEIN
Selecting the Right Level of Positive End-Expiratory Pressure in Patients with Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., April 15, 2002; 165(8): 1182 - 1186.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. GATTINONI, P. CAIRONI, P. PELOSI, and L. R. GOODMAN
What Has Computed Tomography Taught Us about the Acute Respiratory Distress Syndrome?
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1701 - 1711.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. MARTIN-LEFEVRE, J.-D. RICARD, E. ROUPIE, D. DREYFUSS, and G. SAUMON
Significance of the Changes in the Respiratory System Pressure-Volume Curve during Acute Lung Injury in Rats
Am. J. Respir. Crit. Care Med., August 15, 2001; 164(4): 627 - 632.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Mergoni, A. Volpi, C. Bricchi, and A. Rossi
Lower inflection point and recruitment with PEEP in ventilated patients with acute respiratory failure
J Appl Physiol, July 1, 2001; 91(1): 441 - 450.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. J. Tobin
Advances in Mechanical Ventilation
N. Engl. J. Med., June 28, 2001; 344(26): 1986 - 1996.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. A. Wilson, R. C. Anafi, and R. D. Hubmayr
Mechanics of edematous lungs
J Appl Physiol, June 1, 2001; 90(6): 2088 - 2093.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. W. Stroetz, N. E. Vlahakis, B. J. Walters, M. A. Schroeder, and R. D. Hubmayr
Validation of a new live cell strain system: characterization of plasma membrane stress failure
J Appl Physiol, June 1, 2001; 90(6): 2361 - 2370.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. A. Martynowicz, B. J. Walters, and R. D. Hubmayr
Mechanisms of recruitment in oleic acid-injured lungs
J Appl Physiol, May 1, 2001; 90(5): 1744 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. LICHTWARCK-ASCHOFF, G. MOLS, A. J. HEDLUND, V. KESSLER, A. M. MARKSTRÖM, J. GUTTMANN, G. HEDENSTIERNA, and U. H. SJÖSTRAND
Compliance Is Nonlinear over Tidal Volume Irrespective of Positive End-Expiratory Pressure Level in Surfactant-Depleted Piglets
Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2125 - 2133.
[Abstract] [Full Text]

Home page
 Br J AnaesthHome page
M. Lichtwarck-Aschoff, V. Kessler, U. H. Sjostrand, A. Hedlund, G. Mols, S. Rubertsson, A. M. Markstrom, and J. Guttmann
Static versus dynamic respiratory mechanics for setting the ventilator
Br. J. Anaesth., October 1, 2000; 85(4): 577 - 586.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. CAKAR, T. V. d. KLOOT, M. YOUNGBLOOD, A. ADAMS, and A. NAHUM
Oxygenation Response to a Recruitment Maneuver during Supine and Prone Positions in an Oleic Acid-Induced Lung Injury Model
Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1949 - 1956.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society