help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CHIUMELLO, D.
Right arrow Articles by SLUTSKY, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CHIUMELLO, D.
Right arrow Articles by SLUTSKY, A. S.

Am. J. Respir. Crit. Care Med., Volume 160, Number 1, July 1999, 109-116

Mechanical Ventilation Affects Local and Systemic Cytokines in an Animal Model of Acute Respiratory Distress Syndrome

DAVIDE CHIUMELLO, GORSEV PRISTINE, and ARTHUR S. SLUTSKY

Division of Respiratory Medicine, Mount Sinai Hospital, Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Ontario, Canada

We examined the hypothesis that injurious ventilatory strategies (large tidal volume [VT] and/or low positive end-expiratory pressure [PEEP]) would increase release of inflammatory mediators into the lung and into the systemic circulation in a lung injury model. Lung injury was induced in 40 anesthetized paralyzed Sprague-Dawley rats (350 ± 2 g) by hydrochloric acid instillation (pH 1.5, 2.5 ml/kg). Rats were then randomized into five groups (n = 8): (1) high-volume zero PEEP (HVZP): VT, 16 ml/ kg; (2) high-volume PEEP (HVP): VT, 16 ml/kg, PEEP, 5 cm H2O; (3) low-volume zero PEEP (LVZP): VT, 9 ml/kg; (4) low-volume PEEP (LVP): VT, 9 ml/kg, PEEP, 5 cm H2O; (5) same settings as (4) plus a recruitment maneuver performed every hour (LVPR). Respiratory rate was adjusted to maintain normocapnia and fraction of inspired oxygen (FIO2) was 1. Cytokine concentrations (tumor necrosis factor-alpha [TNF-alpha ] and macrophage inflammatory protein-2 [MIP-2]) were measured by ELISA. All animals in the LVZP group died before the end of the experiment. After 4 h of ventilation, the HVZP group had similar lung fluid TNF-alpha concentrations compared with the HVP group: 1,861 ± 333 pg/ml versus 1,259 ± 189 pg/ml; and much higher serum concentrations: 692 ± 74 pg/ml versus 102 ± 31 pg/ml (p < 0.05). An identical pattern was found for MIP-2. These results suggest that the particular ventilatory strategy can affect the release of cytokines into the systemic circulation, a finding that may have relevance for the development of multisystem organ failure.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
J. W. Kuiper, A. M. G. Versteilen, H. W. M. Niessen, R. R. Vaschetto, P. Sipkema, C. J. Heijnen, A. B. J. Groeneveld, and F. B. Plotz
Production of Endothelin-1 and Reduced Blood Flow in the Rat Kidney During Lung-Injurious Mechanical Ventilation
Anesth. Analg., October 1, 2008; 107(4): 1276 - 1283.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. H. Loring and R. B. Banzett
Whole-Body "Negative-Pressure" Ventilation: Is It Really Different?
Am. J. Respir. Crit. Care Med., September 1, 2008; 178(5): 542 - 542.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Iglesias, P. Jungebluth, C. Petit, M. P. Matute, I. Rovira, E. Martinez, M. Catalan, J. Ramirez, and P. Macchiarini
Extracorporeal lung membrane provides better lung protection than conventional treatment for severe postpneumonectomy noncardiogenic acute respiratory distress syndrome.
J. Thorac. Cardiovasc. Surg., June 1, 2008; 135(6): 1362 - 1371.e4.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Grasso, T. Stripoli, M. De Michele, F. Bruno, M. Moschetta, G. Angelelli, I. Munno, V. Ruggiero, R. Anaclerio, A. Cafarelli, et al.
ARDSnet Ventilatory Protocol and Alveolar Hyperinflation: Role of Positive End-Expiratory Pressure
Am. J. Respir. Crit. Care Med., October 15, 2007; 176(8): 761 - 767.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y.-C. Hsieh, M. Frink, C.-H. Hsieh, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry
Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1227 - L1232.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Okutani, B. Han, M. Mura, T. K. Waddell, S. Keshavjee, and M. Liu
High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats
Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L144 - L153.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. A. Frank, P. E. Parsons, and M. A. Matthay
Pathogenetic Significance of Biological Markers of Ventilator-Associated Lung Injury in Experimental and Clinical Studies
Chest, December 1, 2006; 130(6): 1906 - 1914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. A. Frank, C. M. Wray, D. F. McAuley, R. Schwendener, and M. A. Matthay
Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury
Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1191 - L1198.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. A. Simon, R. B. Easley, D. N. Grigoryev, S.-F. Ma, S. Q. Ye, T. Lavoie, R. M. Tuder, and J. G. N. Garcia
Microarray analysis of regional cellular responses to local mechanical stress in acute lung injury
Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L851 - L861.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
T. Dolinay, N. Kaminski, M. Felgendreher, H. P. Kim, P. Reynolds, S. C. Watkins, D. Karp, S. Uhlig, and A. M. K. Choi
Gene expression profiling of target genes in ventilator-induced lung injury
Physiol Genomics, September 14, 2006; 26(1): 68 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Tsuchida, D. Engelberts, V. Peltekova, N. Hopkins, H. Frndova, P. Babyn, C. McKerlie, M. Post, P. McLoughlin, and B. P. Kavanagh
Atelectasis Causes Alveolar Injury in Nonatelectatic Lung Regions
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 279 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Crimi, H. Zhang, R. N. N. Han, L. D. Sorbo, V.M. Ranieri, and A. S. Slutsky
Ischemia and Reperfusion Increases Susceptibility to Ventilator-induced Lung Injury in Rats
Am. J. Respir. Crit. Care Med., July 15, 2006; 174(2): 178 - 186.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. Jiang, Q. Wang, Y. Liu, M. Du, X. Shen, X. Guo, and S. Wu
Total liquid ventilation reduces lung injury in piglets after cardiopulmonary bypass.
Ann. Thorac. Surg., July 1, 2006; 82(1): 124 - 130.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. G. Hall, Y. Liu, J. M. Hickman-Davis, G. C. Davis, C. Myles, E. J. Andrews, S. Matalon, and J. D. Lang Jr.
Bactericidal Function of Alveolar Macrophages in Mechanically Ventilated Rabbits
Am. J. Respir. Cell Mol. Biol., June 1, 2006; 34(6): 719 - 726.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Takenaka, Y. Nishimura, T. Nishiuma, A. Sakashita, T. Yamashita, K. Kobayashi, M. Satouchi, T. Ishida, S. Kawashima, and M. Yokoyama
Ventilator-induced lung injury is reduced in transgenic mice that overexpress endothelial nitric oxide synthase
Am J Physiol Lung Cell Mol Physiol, June 1, 2006; 290(6): L1078 - L1086.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. W. Ryter, J. Alam, and A. M. K. Choi
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Physiol Rev, April 1, 2006; 86(2): 583 - 650.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. R. MacIntyre
Current Issues in Mechanical Ventilation for Respiratory Failure
Chest, November 1, 2005; 128(5_suppl_2): 561S - 567S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Tsuchida, D. Engelberts, M. Roth, C. McKerlie, M. Post, and B. P. Kavanagh
Continuous positive airway pressure causes lung injury in a model of sepsis
Am J Physiol Lung Cell Mol Physiol, October 1, 2005; 289(4): L554 - L564.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
X. Peng, R.-E. E. Abdulnour, S. Sammani, S.-F. Ma, E. J. Han, E. J. Hasan, R. Tuder, J. G. N. Garcia, and P. M. Hassoun
Inducible Nitric Oxide Synthase Contributes to Ventilator-induced Lung Injury
Am. J. Respir. Crit. Care Med., August 15, 2005; 172(4): 470 - 479.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
E. Zupancich, D. Paparella, F. Turani, C. Munch, A. Rossi, S. Massaccesi, and V. M. Ranieri
Mechanical ventilation affects inflammatory mediators in patients undergoing cardiopulmonary bypass for cardiac surgery: A randomized clinical trial
J. Thorac. Cardiovasc. Surg., August 1, 2005; 130(2): 378 - 383.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. H. L. C. van Kaam, R. Lutter, R. A. Lachmann, J. J. Haitsma, E. Herting, M. Snoek, A. De Jaegere, J. H. Kok, and B. Lachmann
Effect of ventilation strategy and surfactant on inflammation in experimental pneumonia
Eur. Respir. J., July 1, 2005; 26(1): 112 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. E. Vlahakis and R. D. Hubmayr
Cellular Stress Failure in Ventilator-injured Lungs
Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1328 - 1342.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Kornecki, S. Tsuchida, H. K. Ondiveeran, D. Engelberts, H. Frndova, A. K. Tanswell, M. Post, C. McKerlie, J. Belik, A. Fox-Robichaud, et al.
Lung Development and Susceptibility to Ventilator-induced Lung Injury
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 743 - 752.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. R. Wilson, S. Choudhury, and M. Takata
Pulmonary inflammation induced by high-stretch ventilation is mediated by tumor necrosis factor signaling in mice
Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L599 - L607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. D. Lang, M. Figueroa, K. D. Sanders, M. Aslan, Y. Liu, P. Chumley, and B. A. Freeman
Hypercapnia via Reduced Rate and Tidal Volume Contributes to Lipopolysaccharide-induced Lung Injury
Am. J. Respir. Crit. Care Med., January 15, 2005; 171(2): 147 - 157.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Yoshikawa, J. A. King, R. N. Lausch, A. M. Penton, F. G. Eyal, and J. C. Parker
Acute ventilator-induced vascular permeability and cytokine responses in isolated and in situ mouse lungs
J Appl Physiol, December 1, 2004; 97(6): 2190 - 2199.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Dolinay, M. Szilasi, M. Liu, and A. M. K. Choi
Inhaled Carbon Monoxide Confers Antiinflammatory Effects against Ventilator-induced Lung Injury
Am. J. Respir. Crit. Care Med., September 15, 2004; 170(6): 613 - 620.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
W. A. Altemeier, G. Matute-Bello, C. W. Frevert, Y. Kawata, O. Kajikawa, T. R. Martin, and R. W. Glenny
Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin
Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L533 - L542.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Kotani, T. Kotani, Z. Li, R. Silbajoris, C.A. Piantadosi, and Y-C.T. Huang
Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch
Eur. Respir. J., August 1, 2004; 24(2): 238 - 246.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
P. Prodhan and N. Noviski
Pediatric Acute Hypoxemic Respiratory Failure: Management of Oxygenation
J Intensive Care Med, May 1, 2004; 19(3): 140 - 153.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. B. Copland, F. Martinez, B. P. Kavanagh, D. Engelberts, C. McKerlie, J. Belik, and M. Post
High Tidal Volume Ventilation Causes Different Inflammatory Responses in Newborn versus Adult Lung
Am. J. Respir. Crit. Care Med., March 15, 2004; 169(6): 739 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
H. Wrigge, U. Uhlig, J. Zinserling, E. Behrends-Callsen, G. Ottersbach, M. Fischer, S. Uhlig, and C. Putensen
The Effects of Different Ventilatory Settings on Pulmonary and Systemic Inflammatory Responses During Major Surgery
Anesth. Analg., March 1, 2004; 98(3): 775 - 781.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Ikegami, S. G. Kallapur, and A. H. Jobe
Initial responses to ventilation of premature lambs exposed to intra-amniotic endotoxin 4 days before delivery
Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L573 - L579.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
E. D. Moloney and M. J. D. Griffiths
Protective ventilation of patients with acute respiratory distress syndrome
Br. J. Anaesth., February 1, 2004; 92(2): 261 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
U. Uhlig, H. Fehrenbach, R. A. Lachmann, T. Goldmann, B. Lachmann, E. Vollmer, and S. Uhlig
Phosphoinositide 3-OH Kinase Inhibition Prevents Ventilation-induced Lung Cell Activation
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 201 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H.A. Vreugdenhil, C.J. Heijnen, F.B. Plotz, J. Zijlstra, N.J. Jansen, J.J. Haitsma, B. Lachmann, and A.J. van Vught
Mechanical ventilation of healthy rats suppresses peripheral immune function
Eur. Respir. J., January 1, 2004; 23(1): 122 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. M. Steinberg, H. J. Schiller, J. M. Halter, L. A. Gatto, H.-M. Lee, L. A. Pavone, and G. F. Nieman
Alveolar Instability Causes Early Ventilator-induced Lung Injury Independent of Neutrophils
Am. J. Respir. Crit. Care Med., January 1, 2004; 169(1): 57 - 63.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. W. Bollen, C. S. P. M. Uiterwaal, and A. J. van Vught
Cumulative Metaanalysis of High-frequency Versus Conventional Ventilation in Premature Neonates
Am. J. Respir. Crit. Care Med., November 15, 2003; 168(10): 1150 - 1155.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. B. Copland, B. P. Kavanagh, D. Engelberts, C. McKerlie, J. Belik, and M. Post
Early Changes in Lung Gene Expression due to High Tidal Volume
Am. J. Respir. Crit. Care Med., November 1, 2003; 168(9): 1051 - 1059.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Wilson, S. Choudhury, M. E. Goddard, K. P. O'Dea, A. G. Nicholson, and M. Takata
High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury
J Appl Physiol, October 1, 2003; 95(4): 1385 - 1393.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J-D. Ricard, D. Dreyfuss, and G. Saumon
Ventilator-induced lung injury
Eur. Respir. J., August 1, 2003; 22(42_suppl): 2s - 9s.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.P. Terragni, G.L. Rosboch, A. Lisi, A.G. Viale, and V.M. Ranieri
How respiratory system mechanics may help in minimising ventilator-induced lung injury in ARDS patients
Eur. Respir. J., August 1, 2003; 22(42_suppl): 15s - 21s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Duggan, C. L. McCaul, P. J. McNamara, D. Engelberts, C. Ackerley, and B. P. Kavanagh
Atelectasis Causes Vascular Leak and Lethal Right Ventricular Failure in Uninjured Rat Lungs
Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1633 - 1640.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Dreyfuss, J.-D. Ricard, and G. Saumon
On the Physiologic and Clinical Relevance of Lung-borne Cytokines during Ventilator-induced Lung Injury
Am. J. Respir. Crit. Care Med., June 1, 2003; 167(11): 1467 - 1471.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. M. Maggiore, F. Lellouche, J. Pigeot, S. Taille, N. Deye, X. Durrmeyer, J.-C. Richard, J. Mancebo, F. Lemaire, and L. Brochard
Prevention of Endotracheal Suctioning-induced Alveolar Derecruitment in Acute Lung Injury
Am. J. Respir. Crit. Care Med., May 1, 2003; 167(9): 1215 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Tsangaris, M.E. Lekka, E. Kitsiouli, S. Constantopoulos, and G. Nakos
Bronchoalveolar lavage alterations during prolonged ventilation of patients without acute lung injury
Eur. Respir. J., March 1, 2003; 21(3): 495 - 501.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. Lesur, C. Hermans, J.-F. Chalifour, J. Picotte, B. Levy, A. Bernard, and D. Lane
Mechanical ventilation-induced pneumoprotein CC-16 vascular transfer in rats: effect of KGF pretreatment
Am J Physiol Lung Cell Mol Physiol, February 1, 2003; 284(2): L410 - L419.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. E. Baumgardner, K. Markstaller, B. Pfeiffer, M. Doebrich, and C. M. Otto
Effects of Respiratory Rate, Plateau Pressure, and Positive End-Expiratory Pressure on PaO2 Oscillations after Saline Lavage
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1556 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. de Perrot, Y. Imai, G. A. Volgyesi, T. K. Waddell, M. Liu, J. B. Mullen, K. McRae, H. Zhang, A. S. Slutsky, V. M. Ranieri, et al.
Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model
J. Thorac. Cardiovasc. Surg., December 1, 2002; 124(6): 1137 - 1144.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Derdak, S. Mehta, T. E. Stewart, T. Smith, M. Rogers, T. G. Buchman, B. Carlin, S. Lowson, J. Granton, and the Multicenter Oscillatory Ventilation
High-Frequency Oscillatory Ventilation for Acute Respiratory Distress Syndrome in Adults: A Randomized, Controlled Trial
Am. J. Respir. Crit. Care Med., September 15, 2002; 166(6): 801 - 808.
[Abstract] [Full Text]

Home page
 ThoraxHome page
T Whitehead and A S Slutsky
The pulmonary physician in critical care * 7: Ventilator induced lung injury
Thorax, July 1, 2002; 57(7): 635 - 642.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K.-C. Cheng, H. Zhang, C.-Y. Lin, and A. S. Slutsky
Ventilation with Negative Airway Pressure Induces a Cytokine Response in Isolated Mouse Lung
Anesth. Analg., June 1, 2002; 94(6): 1577 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Uhlig
Mechanotransduction in the Lung: Ventilation-induced lung injury and mechanotransduction: stretching it too far?
Am J Physiol Lung Cell Mol Physiol, May 1, 2002; 282(5): L892 - L896.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. W. KRAMER, M. IKEGAMI, and A. H. JOBE
Intratracheal Endotoxin Causes Systemic Inflammation in Ventilated Preterm Lambs
Am. J. Respir. Crit. Care Med., February 15, 2002; 165(4): 463 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. A. FRANK, J. A. GUTIERREZ, K. D. JONES, L. ALLEN, L. DOBBS, and M. A. MATTHAY
Low Tidal Volume Reduces Epithelial and Endothelial Injury in Acid-injured Rat Lungs
Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 242 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. GATTINONI, P. CAIRONI, P. PELOSI, and L. R. GOODMAN
What Has Computed Tomography Taught Us about the Acute Respiratory Distress Syndrome?
Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1701 - 1711.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. W. LU, H. W. TAEUSCH, B. ROBERTSON, J. GOERKE, and J. A. CLEMENTS
Polyethylene Glycol/Surfactant Mixtures Improve Lung Function after HCl and Endotoxin Lung Injuries
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1531 - 1536.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Imai, S. Nakagawa, Y. Ito, T. Kawano, A. S. Slutsky, and K. Miyasaka
Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilation
J Appl Physiol, October 1, 2001; 91(4): 1836 - 1844.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. S. Slutsky
The Acute Respiratory Distress Syndrome, Mechanical Ventilation, and the Prone Position
N. Engl. J. Med., August 23, 2001; 345(8): 610 - 612.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. A. Simon
Message in a Model
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1043 - 1044.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J.-D. RICARD, D. DREYFUSS, and G. SAUMON
Production of Inflammatory Cytokines in Ventilator-Induced Lung Injury: A Reappraisal
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1176 - 1180.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page