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Am. J. Respir. Crit. Care Med., Volume 159, Number 6, June 1999, 1796-1802

Suggestive Evidence for Genetic Linkage Between IgE Phenotypes and Chromosome 14q Markers

ADEL H. MANSUR, D. TIMOTHY BISHOP, ALEX F. MARKHAM, NEWTON E. MORTON, STEPHEN T. HOLGATE, and JOHN F. J. MORRISON

Molecular Medicine Unit and ICRF, Ashley Wing, St. James's University Hospital, Leeds; Genetic Epidemiology Research Group, Princess Anne Hospital, and Immunopharmacology Group, University Medicine, Southampton General Hospital, Southampton, United Kingdom

Chromosome 14q was screened for loci modulating immunoglobulin E (IgE) phenotypes in 15 extended and 45 nuclear asthmatic families using a panel of 14 microsatellite markers. We examined the reported linkage between the TCR A/D locus on 14q11.2 and specific (cognate) allergic responses and observed supportive evidence for linkage between a general skin prick test reactivity trait (but not with total serum IgE) and TCRA microsatellite (in the total sample of informative sib-pairs p = 0.039, in selected sample of one or zero affected parent p = 0.017). We also show suggestive evidence for a novel linkage between markers D14S75 and D14S63 on 14q13-23 and log total serum IgE (p = 0.034 and p = 0.0029). The evidence for linkage with marker D14S63 on 14q23 is strengthened by the finding of association of allele 165 to log IgE (p = 0.0029). We conclude that chromosome 14q may contain a locus close to TCR A/D at 14q11.2 linked to skin prick reactivity and a locus at 14q13- 23 linked to total serum IgE.




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