help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MANSUR, A. H.
Right arrow Articles by MORRISON, J. F. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MANSUR, A. H.
Right arrow Articles by MORRISON, J. F. J.

Am. J. Respir. Crit. Care Med., Volume 159, Number 6, June 1999, 1796-1802

Suggestive Evidence for Genetic Linkage Between IgE Phenotypes and Chromosome 14q Markers

ADEL H. MANSUR, D. TIMOTHY BISHOP, ALEX F. MARKHAM, NEWTON E. MORTON, STEPHEN T. HOLGATE, and JOHN F. J. MORRISON

Molecular Medicine Unit and ICRF, Ashley Wing, St. James's University Hospital, Leeds; Genetic Epidemiology Research Group, Princess Anne Hospital, and Immunopharmacology Group, University Medicine, Southampton General Hospital, Southampton, United Kingdom

Chromosome 14q was screened for loci modulating immunoglobulin E (IgE) phenotypes in 15 extended and 45 nuclear asthmatic families using a panel of 14 microsatellite markers. We examined the reported linkage between the TCR A/D locus on 14q11.2 and specific (cognate) allergic responses and observed supportive evidence for linkage between a general skin prick test reactivity trait (but not with total serum IgE) and TCRA microsatellite (in the total sample of informative sib-pairs p = 0.039, in selected sample of one or zero affected parent p = 0.017). We also show suggestive evidence for a novel linkage between markers D14S75 and D14S63 on 14q13-23 and log total serum IgE (p = 0.034 and p = 0.0029). The evidence for linkage with marker D14S63 on 14q23 is strengthened by the finding of association of allele 165 to log IgE (p = 0.0029). We conclude that chromosome 14q may contain a locus close to TCR A/D at 14q11.2 linked to skin prick reactivity and a locus at 14q13- 23 linked to total serum IgE.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Sharma, J. Batra, U. Mabalirajan, S. Sharma, R. Nagarkatti, J. Aich, S. K. Sharma, P. V. Niphadkar, and B. Ghosh
A Genetic Variation in Inositol Polyphosphate 4 Phosphatase A Enhances Susceptibility to Asthma
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 712 - 719.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
T. Oguma, L. J. Palmer, E. Birben, L. A. Sonna, K. Asano, and C. M. Lilly
Role of Prostanoid DP Receptor Variants in Susceptibility to Asthma
N. Engl. J. Med., October 21, 2004; 351(17): 1752 - 1763.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A H Mansur, D T Bishop, S T Holgate, A F Markham, and J F J Morrison
Linkage/association study of a locus modulating total serum IgE on chromosome 14q13-24 in families with asthma
Thorax, October 1, 2004; 59(10): 876 - 882.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society 		  CCM abstracts