help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van SUYLEN, R. J.
Right arrow Articles by DAEMEN, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van SUYLEN, R. J.
Right arrow Articles by DAEMEN, M. J.

Am. J. Respir. Crit. Care Med., Volume 159, Number 6, June 1999, 1791-1795

The DD Genotype of the Angiotensin Converting Enzyme Gene Is Negatively Associated with Right Ventricular Hypertrophy In Male Patients with Chronic Obstructive Pulmonary Disease

ROBERT J. van SUYLEN, EMIEL F. WOUTERS, HERMAN J. PENNINGS, EMILE C. CHERIEX, PETRA E. van POL, ANTON W. AMBERGEN, ANNE-MARIE VERMELIS, and MAT J. DAEMEN

Departments of Pathology, Cardiology, Pulmonology and Asthmacentre Hornerheide, Horn; Department of Methodology and Statistics; Cardiovascular Research Institute Maastricht, and Nutrition Toxicology and Environment Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

The renin angiotensin system plays an important role in the development of pulmonary artery remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary hypertension as may occur in patients with COPD. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T polymorphism in the angiotensinogen gene, the 287-base-pair insertion (I)/deletion (D) polymorphism at intron 16 of the ACE gene, and the A1166C polymorphism in the angiotensin II type 1 receptor gene have been associated with an increased risk of cardiovascular diseases. With respect to the pulmonary circulation, only limited data exist on possible associations between polymorphisms of these genes and pulmonary hypertension and/or right ventricular hypertrophy. The objective of the present study was to investigate a possible relationship between polymorphisms of the renin angiotensin system and electrocardiographic evidence of right ventricular hypertrophy in patients with COPD. We therefore determined the angiotensinogen (M235T), angiotensin converting enzyme (I/D), and angiotensin II type 1 receptor (A1166C) genotypes in 87 patients with severe COPD and correlated these data with electrocardiographic parameters of right ventricular hypertrophy. Thirty-one patients (36%) of 87 patients with COPD showed electrocardiographic evidence of right ventricular hypertrophy. In the male, but not in the female, subgroup, the angiotensin-converting enzyme DD genotype was negatively associated with electrocardiographic evidence of right ventricular hypertrophy (male: chi 2 = 3.8, p = 0.05; female: chi 2 = 0.05, p = 0.82). We found no associations between the investigated polymorphisms in the angiotensinogen and angiotensin II type 1 receptor genes and electrocardiographic evidence of right ventricular hypertrophy.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
H. R. Gosker, H.-J. Pennings, and A. M. W. J. Schols
ACE Gene Polymorphism in COPD
Am. J. Respir. Crit. Care Med., September 1, 2004; 170(5): 572 - 572.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. S. Hopkinson, A. H. Nickol, J. Payne, E. Hawe, W. D.-C. Man, J. Moxham, H. Montgomery, and M. I. Polkey
Angiotensin Converting Enzyme Genotype and Strength in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., August 15, 2004; 170(4): 395 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A.G.N. Agusti, A. Noguera, J. Sauleda, E. Sala, J. Pons, and X. Busquets
Systemic effects of chronic obstructive pulmonary disease
Eur. Respir. J., February 1, 2003; 21(2): 347 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. A. Aldashev, A. S. Sarybaev, A. S. Sydykov, B. B. Kalmyrzaev, E. V. Kim, L. B. Mamanova, R. Maripov, B. K. Kojonazarov, M. M. Mirrakhimov, M. R. Wilkins, et al.
Characterization of High-Altitude Pulmonary Hypertension in the Kyrgyz: Association with Angiotensin-Converting Enzyme Genotype
Am. J. Respir. Crit. Care Med., November 15, 2002; 166(10): 1396 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. J. van SUYLEN, W. M. AARTSEN, J. F. M. SMITS, and M. J. A. P. DAEMEN
Dissociation of Pulmonary Vascular Remodeling and Right Ventricular Pressure in Tissue Angiotensin-converting Enzyme-deficient Mice Under Conditions of Chronic Alveolar Hypoxia
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1241 - 1245.
[Abstract] [Full Text]

Home page
 Eur Respir JHome page
M.A. Higham, D. Dawson, J. Joshi, P. Nihoyannopoulos, and N.W. Morrell
Utility of echocardiography in assessment of pulmonary hypertension secondary to COPD
Eur. Respir. J., March 1, 2001; 17(3): 350 - 355.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society