help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HACZKU, A.
Right arrow Articles by GELFAND, E. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HACZKU, A.
Right arrow Articles by GELFAND, E. W.

Am. J. Respir. Crit. Care Med., Volume 159, Number 5, May 1999, 1638-1643

Anti-CD86 (B7.2) Treatment Abolishes Allergic Airway Hyperresponsiveness in Mice

ANGELA HACZKU, KATSUYUKI TAKEDA, IMRE REDAI, ECKARD HAMELMANN, GREGORY CIESLEWICZ, ANTHONY JOETHAM, JOAN LOADER, JAMES J. LEE, CHARLES IRVIN, and ERWIN W. GELFAND

Division of Basic Sciences, Department of Pediatrics and Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado; and Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona

Allergic sensitization in asthma develops as a consequence of complex interactions between T cells and antigen-presenting cells. We have developed several in vivo models to study allergen-specific T cell and B cell function and their relevance to allergic airway hyperresponsiveness (AHR), focusing on the role of the costimulatory molecules CD80 and CD86. Treatment of mice with anti-CD86, but not anti-CD80, significantly inhibited increased serum levels of ovalbumin (OA)-specific IgE and IgG1, airway eosinophilia, and AHR both after 10 d of OA aerosol exposure (in the absence of adjuvant) and after intraperitoneal sensitization followed by repeated airway challenges. Inhibition of AHR was associated with decreased IL-4 and IL-5 levels in the BAL fluid of sensitized mice, suggesting impaired Th2 function in anti-CD86-treated animals. This effect was not seen when mice received treatment only before allergen challenge, indicating that anti-CD86 acts through inhibition of allergic sensitization and not simply by inhibiting the influx of inflammatory cells. These data suggest that the CD86 costimulatory ligand plays a major role in the development of allergic inflammation and AHR in allergen-challenged mice. Further, this study demonstrates that T-B cell interactions during allergic sensitization are amenable to therapeutic manipulation and that selective blockade of accessory signals can be an effective means for modulating distinct T cell functions.




This article has been cited by other articles:


Home page
 Arch DermatolHome page
A. Cuellar, E. Garcia, A. Rodriguez, E. Halpert, and A. Gomez
Functional Dysregulation of Dendritic Cells in Patients With Papular Urticaria Caused by Fleabite
Arch Dermatol, November 1, 2007; 143(11): 1415 - 1419.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. C. Beier, T. Kallinich, and E. Hamelmann
T-cell co-stimulatory molecules: novel targets for the treatment of allergic airway disease
Eur. Respir. J., August 1, 2007; 30(2): 383 - 390.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. R. Crosby, M. Guha, D. Tung, D. A. Miller, B. Bender, T. P. Condon, C. York-DeFalco, R. S. Geary, B. P. Monia, J. G. Karras, et al.
Inhaled CD86 Antisense Oligonucleotide Suppresses Pulmonary Inflammation and Airway Hyper-Responsiveness in Allergic Mice
J. Pharmacol. Exp. Ther., June 1, 2007; 321(3): 938 - 946.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. C. Webb, Y. Cai, K. I. Matthaei, and P. S. Foster
Comparative Roles of IL-4, IL-13, and IL-4R{alpha} in Dendritic Cell Maturation and CD4+ Th2 Cell Function
J. Immunol., January 1, 2007; 178(1): 219 - 227.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
X.-D. Liang, H.-Z. Shi, X.-J. Qin, and J.-M. Deng
Increase in Concentration of Soluble CD86 After Segmental Allergen Challenge in Patients With Allergic Asthma.
Chest, October 1, 2006; 130(4): 1048 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Matsubara, T. Koya, K. Takeda, A. Joetham, N. Miyahara, P. Pine, E. S. Masuda, C. H. Swasey, and E. W. Gelfand
Syk Activation in Dendritic Cells Is Essential for Airway Hyperresponsiveness and Inflammation
Am. J. Respir. Cell Mol. Biol., April 1, 2006; 34(4): 426 - 433.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Ettmayer, P. Mayer, F. Kalthoff, W. Neruda, N. Harrer, G. Hartmann, M. M. Epstein, V. Brinkmann, C. Heusser, and M. Woisetschlager
A Novel Low Molecular Weight Inhibitor of Dendritic Cells and B Cells Blocks Allergic Inflammation
Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 599 - 606.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
H-Z Shi, Z-F Xie, J-M Deng, Y-Q Chen, and C-Q Xiao
Soluble CD86 protein in serum samples of patients with asthma
Thorax, October 1, 2004; 59(10): 870 - 875.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Wittke, V. Weaver, B. D. Mahon, A. August, and M. T. Cantorna
Vitamin D Receptor-Deficient Mice Fail to Develop Experimental Allergic Asthma
J. Immunol., September 1, 2004; 173(5): 3432 - 3436.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Yang, A. Haczku, H. Chen, V. Martin, H. Galczenski, Y. Tomer, C. R. Van Beisen, J. F. Evans, R. A. Panettieri, and C. D. Funk
Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4
Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L992 - L1001.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Matsumoto, H. Inoue, T. Nakano, M. Tsuda, Y. Yoshiura, S. Fukuyama, F. Tsushima, T. Hoshino, H. Aizawa, H. Akiba, et al.
B7-DC Regulates Asthmatic Response by an IFN-{gamma}-Dependent Mechanism
J. Immunol., February 15, 2004; 172(4): 2530 - 2541.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Gosset, F. Bureau, V. Angeli, M. Pichavant, C. Faveeuw, A.-B. Tonnel, and F. Trottein
Prostaglandin D2 Affects the Maturation of Human Monocyte-Derived Dendritic Cells: Consequence on the Polarization of Naive Th Cells
J. Immunol., May 15, 2003; 170(10): 4943 - 4952.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Mueller and A. August
Attenuation of Immunological Symptoms of Allergic Asthma in Mice Lacking the Tyrosine Kinase ITK
J. Immunol., May 15, 2003; 170(10): 5056 - 5063.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Q. Ye, P. W. Finn, R. Sweeney, E. K. Bikoff, and R. J. Riese
MHC Class II-Associated Invariant Chain Isoforms Regulate Pulmonary Immune Responses
J. Immunol., February 1, 2003; 170(3): 1473 - 1480.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Haczku, E. N. Atochina, Y. Tomer, Y. Cao, C. Campbell, S. T. Scanlon, S. J. Russo, G. Enhorning, and M. F. Beers
The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice
Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L755 - L765.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. OKANO, M. AZUMA, T. YOSHINO, H. HATTORI, M. NAKADA, A. R. SATOSKAR, D. A. HARN Jr, E. NAKAYAMA, T. AKAGI, and K. NISHIZAKI
Differential Role of CD80 and CD86 Molecules in the Induction and the Effector Phases of Allergic Rhinitis in Mice
Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1501 - 1507.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. M. Walter, J. J. McIntire, G. Berry, A. N. J. McKenzie, D. D. Donaldson, R. H. DeKruyff, and D. T. Umetsu
Critical Role for IL-13 in the Development of Allergen-Induced Airway Hyperreactivity
J. Immunol., October 15, 2001; 167(8): 4668 - 4675.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. Hammad, A.-S. Charbonnier, C. Duez, A. Jacquet, G. A. Stewart, A.-B. Tonnel, and J. Pestel
Th2 polarization by Der p 1-pulsed monocyte-derived dendritic cells is due to the allergic status of the donors
Blood, August 15, 2001; 98(4): 1135 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. Haczku, E. N. Atochina, Y. Tomer, H. Chen, S. T. Scanlon, S. Russo, J. Xu, R. A. Panettieri Jr., and M. F. Beers
Aspergillus fumigatus-Induced Allergic Airway Inflammation Alters Surfactant Homeostasis and Lung Function in BALB/c Mice
Am. J. Respir. Cell Mol. Biol., July 1, 2001; 25(1): 45 - 50.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. L. Denzler, S. C. Farmer, J. R. Crosby, M. Borchers, G. Cieslewicz, K. A. Larson, S. Cormier-Regard, N. A. Lee, and J. J. Lee
Eosinophil Major Basic Protein-1 Does Not Contribute to Allergen-Induced Airway Pathologies in Mouse Models of Asthma
J. Immunol., November 15, 2000; 165(10): 5509 - 5517.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Serebrisky, A. A. Teper, C.-K. Huang, S.-Y. Lee, T.-F. Zhang, B. H. Schofield, M. Kattan, H. A. Sampson, and X.-M. Li
CpG Oligodeoxynucleotides Can Reverse Th2-Associated Allergic Airway Responses and Alter the B7.1/B7.2 Expression in a Murine Model of Asthma
J. Immunol., November 15, 2000; 165(10): 5906 - 5912.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. Makela, A. Kanehiro, L. Borish, A. Dakhama, J. Loader, A. Joetham, Z. Xing, M. Jordana, G. L. Larsen, and E. W. Gelfand
IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization
PNAS, May 23, 2000; 97(11): 6007 - 6012.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society