Am. J. Respir. Crit. Care Med., Volume 159, Number 4, April 1999, 1215-1219

Circulating Leptin in Patients with Chronic Obstructive Pulmonary Disease

NORIAKI TAKABATAKE, HIDENORI NAKAMURA, SHUICHI ABE, TOSHIHIKO HINO, HIROSHI SAITO, HIDEKI YUKI, SHUICHI KATO, and HITONOBU TOMOIKE

First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan

Unexplained weight loss is common in patients with chronic obstructive pulmonary disease (COPD). Since leptin, an obesity gene product, is known to play important roles in the control of body weight and energy expenditure, we investigated serum leptin levels, along with circulating tumor necrosis factor- (TNF-) and soluble TNF receptor (sTNF-R55 and -R75) levels, in 31 patients with COPD and 15 age-matched healthy controls. The body mass index (BMI) and percent body fat (%fat) were significantly lower in the COPD patients than in the healthy controls (BMI = 18.1 ± 2.7 kg/m² versus 22.8 ± 2.2 kg/m² [mean ± SD]; p < 0.0001; %fat = 16.9 ± 5.8% versus 24.3 ± 4.9%; p < 0.001). Serum leptin levels were significantly lower in the COPD patients than in the healthy controls (1.14 ± 1.17 ng/ml versus 2.47 ± 2.01 ng/ml; p < 0.05). In contrast, serum TNF- levels (6.59 ± 1.92 pg/ml versus 5.41 ± 1.60 pg/ml; p < 0.05), plasma sTNF-R55 (1.16 ± 0.47 ng/ml versus 0.67 ± 0.13 ng/ml; p < 0.0001) and sTNF-R75 (3.65 ± 1.29 ng/ml versus 2.25 ± 0.43 ng/ml; p < 0.0001) levels were significantly higher in the COPD patients than in the healthy controls. Importantly, circulating leptin levels (log transformed) did correlate well with BMI and %fat, but not with TNF- or with sTNF-R levels in the COPD patients. These data suggest that circulating leptin is independent of the TNF- system and is regulated physiologically even in the presence of cachexia in patients with COPD.

This article has been cited by other articles:

				E. F. M. Wouters, N. L. Reynaert, M. A. Dentener, and J. H. J. Vernooy Systemic and Local Inflammation in Asthma and Chronic Obstructive Pulmonary Disease: Is There a Connection? Proceedings of the ATS, December 15, 2009; 6(8): 638 - 647. [Abstract] [Full Text] [PDF]

				P. D. Wagner Possible mechanisms underlying the development of cachexia in COPD Eur. Respir. J., March 1, 2008; 31(3): 492 - 501. [Abstract] [Full Text] [PDF]

				E Barreiro, A M W J Schols, M I Polkey, J B Galdiz, H R Gosker, E B Swallow, C Coronell, J Gea, and on behalf of the ENIGMA in COPD project Cytokine profile in quadriceps muscles of patients with severe COPD Thorax, February 1, 2008; 63(2): 100 - 107. [Abstract] [Full Text] [PDF]

				N. Takabatake, Y. Shibata, S. Abe, T. Wada, J.-i. Machiya, A. Igarashi, Y. Tokairin, G. Ji, H. Sato, M. Sata, et al. A Single Nucleotide Polymorphism in the CCL1 Gene Predicts Acute Exacerbations in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., October 15, 2006; 174(8): 875 - 885. [Abstract] [Full Text] [PDF]

				H. Chen, M. J. Hansen, J. E. Jones, R. Vlahos, S. Bozinovski, G. P. Anderson, and M. J. Morris Cigarette Smoke Exposure Reprograms the Hypothalamic Neuropeptide Y Axis to Promote Weight Loss Am. J. Respir. Crit. Care Med., June 1, 2006; 173(11): 1248 - 1254. [Abstract] [Full Text] [PDF]

				N. Takabatake, M. Sata, S. Inoue, Y. Shibata, S. Abe, T. Wada, J.-i. Machiya, G. Ji, T. Matsuura, Y. Takeishi, et al. A Novel Polymorphism in Secretory Phospholipase A2-IID Is Associated with Body Weight Loss in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., November 1, 2005; 172(9): 1097 - 1104. [Abstract] [Full Text] [PDF]

				Q. Huang, X. Zhang, Z.-W. Jiang, B.-Z. Liu, N. Li, and J.-S. Li Hypoleptinemia in Gastric Cancer Patients: Relation to Body Fat Mass, Insulin, and Growth Hormone JPEN J Parenter Enteral Nutr, July 1, 2005; 29(4): 229 - 235. [Abstract] [Full Text] [PDF]

				E. F. M. Wouters Local and Systemic Inflammation in Chronic Obstructive Pulmonary Disease Proceedings of the ATS, April 1, 2005; 2(1): 26 - 33. [Abstract] [Full Text] [PDF]

				S. F. P. Man and D. D. Sin Effects of Corticosteroids on Systemic Inflammation in Chronic Obstructive Pulmonary Disease Proceedings of the ATS, April 1, 2005; 2(1): 78 - 82. [Abstract] [Full Text] [PDF]

				R. Casaburi, S. Bhasin, L. Cosentino, J. Porszasz, A. Somfay, M. I. Lewis, M. Fournier, and T. W. Storer Effects of Testosterone and Resistance Training in Men with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., October 15, 2004; 170(8): 870 - 878. [Abstract] [Full Text] [PDF]

				M. R. Mazan, E. F. Deveney, S. DeWitt, D. Bedenice, and A. Hoffman Energetic cost of breathing, body composition, and pulmonary function in horses with recurrent airway obstruction J Appl Physiol, July 1, 2004; 97(1): 91 - 97. [Abstract] [Full Text] [PDF]

				W Q Gan, S F P Man, A Senthilselvan, and D D Sin Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis Thorax, July 1, 2004; 59(7): 574 - 580. [Abstract] [Full Text] [PDF]

				H. Andreassen and J. Vestbo Chronic obstructive pulmonary disease as a systemic disease: an epidemiological perspective Eur. Respir. J., November 2, 2003; 22(46_suppl): 2s - 4s. [Abstract] [Full Text] [PDF]

				T. Arao, N. Takabatake, M. Sata, S. Abe, Y. Shibata, T. Honma, K. Takahashi, A. Okada, Y. Takeishi, and I. Kubota In Vivo Evidence of Endothelial Injury in Chronic Obstructive Pulmonary Disease by Lung Scintigraphic Assessment of 123I-Metaiodobenzylguanidine J. Nucl. Med., November 1, 2003; 44(11): 1747 - 1754. [Abstract] [Full Text] [PDF]

				R. I. Cohen, K. Marzouk, P. Berkoski, C. P. O'Donnell, V. Y. Polotsky, and S. M. Scharf Body Composition and Resting Energy Expenditure in Clinically Stable, Non-Weight-Losing Patients With Severe Emphysema Chest, October 1, 2003; 124(4): 1365 - 1372. [Abstract] [Full Text] [PDF]

				E F M Wouters Eat well to get well Thorax, September 1, 2003; 58(9): 739 - 740. [Full Text] [PDF]

				D D Sin and S F P Man Impaired lung function and serum leptin in men and women with normal body weight: a population based study Thorax, August 1, 2003; 58(8): 695 - 698. [Abstract] [Full Text] [PDF]

				R.A. Rabinovich, M. Figueras, E. Ardite, N. Carbo, T. Troosters, X. Filella, J.A. Barbera, J.C. Fernandez-Checa, J.M. Argiles, and J. Roca Increased tumour necrosis factor-{alpha} plasma levels during moderate-intensity exercise in COPD patients Eur. Respir. J., May 1, 2003; 21(5): 789 - 794. [Abstract] [Full Text] [PDF]

				T. Matsumura, M. Nakayama, H. Satoh, A. Naito, K. Kamahara, and K. Sekizawa Plasma Orexin-A Levels and Body Composition in COPD Chest, April 1, 2003; 123(4): 1060 - 1065. [Abstract] [Full Text] [PDF]

				A.G.N. Agusti, A. Noguera, J. Sauleda, E. Sala, J. Pons, and X. Busquets Systemic effects of chronic obstructive pulmonary disease Eur. Respir. J., February 1, 2003; 21(2): 347 - 360. [Abstract] [Full Text] [PDF]

				F. Santolaria, A. Perez-Cejas, M.-R. Aleman, E. Gonzalez-Reimers, A. Milena, M.-J. De La Vega, A. Martinez-Riera, and M.-A. Gomez-Rodriguez LOW SERUM LEPTIN LEVELS AND MALNUTRITION IN CHRONIC ALCOHOL MISUSERS HOSPITALIZED BY SOMATIC COMPLICATIONS Alcohol Alcohol., January 1, 2003; 38(1): 60 - 66. [Abstract] [Full Text] [PDF]

				E F M Wouters Chronic obstructive pulmonary disease * 5: Systemic effects of COPD Thorax, December 1, 2002; 57(12): 1067 - 1070. [Abstract] [Full Text] [PDF]

				J. H. Vernooy, M. Kucukaycan, J. A. Jacobs, N. H. Chavannes, W. A. Buurman, M. A. Dentener, and E. F. Wouters Local and Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease: Soluble Tumor Necrosis Factor Receptors Are Increased in Sputum Am. J. Respir. Crit. Care Med., November 1, 2002; 166(9): 1218 - 1224. [Abstract] [Full Text] [PDF]

				E. F. M. Wouters, E. C. Creutzberg, and A. M. W. J. Schols Systemic Effects in COPD* Chest, May 1, 2002; 121 (2009): 127S - 130S. [Abstract] [Full Text] [PDF]

				C. Barazzone-Argiroffo, P. Muzzin, Y. R. Donati, C.-D. Kan, M. L. Aubert, and P.-F. Piguet Hyperoxia increases leptin production: a mechanism mediated through endogenous elevation of corticosterone Am J Physiol Lung Cell Mol Physiol, November 1, 2001; 281(5): L1150 - L1156. [Abstract] [Full Text] [PDF]

				A. L. Goldberger Heartbeats, Hormones, and Health . Is Variability the Spice of Life? Am. J. Respir. Crit. Care Med., May 1, 2001; 163(6): 1289 - 1290. [Full Text]

				N. TAKABATAKE, H. NAKAMURA, O. MINAMIHABA, M. INAGE, S. INOUE, S. KAGAYA, M. YAMAKI, and H. TOMOIKE A Novel Pathophysiologic Phenomenon in Cachexic Patients with Chronic Obstructive Pulmonary Disease . The Relationship between the Circadian Rhythm of Circulating Leptin and the Very Low-Frequency Component of Heart Rate Variability Am. J. Respir. Crit. Care Med., May 1, 2001; 163(6): 1314 - 1319. [Abstract] [Full Text]

				D. P. Kotler Cachexia Ann Intern Med, October 17, 2000; 133(8): 622 - 634. [Abstract] [Full Text] [PDF]

				G. Fantuzzi and R. Faggioni Leptin in the regulation of immunity, inflammation, and hematopoiesis J. Leukoc. Biol., October 1, 2000; 68(4): 437 - 446. [Abstract] [Full Text]

				M. S. M. Ip, K. S. L. Lam, C.-m. Ho, K. W. T. Tsang, and W.-k. Lam Serum Leptin and Vascular Risk Factors in Obstructive Sleep Apnea Chest, September 1, 2000; 118(3): 580 - 586. [Abstract] [Full Text] [PDF]

				E. F.M. Wouters Nutrition and Metabolism in COPD Chest, May 1, 2000; 117 (2009): 274S - 280S. [Full Text] [PDF]

				N. TAKABATAKE, H. NAKAMURA, S. ABE, S. INOUE, T. HINO, H. SAITO, H. YUKI, S. KATO, and H. TOMOIKE The Relationship between Chronic Hypoxemia and Activation of the Tumor Necrosis Factor-alpha System in Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1179 - 1184. [Abstract] [Full Text]

				G. Filippatos, K. Tsilias, G. Baltopoulos, and L. Anthopoulos Serum leptin concentration in heart failure patients: does the literature reflect reality? Eur. Heart J., February 2, 2000; 21(4): 334 - 334. [PDF]