help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GUERIN, C.
Right arrow Articles by FOURNIER, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GUERIN, C.
Right arrow Articles by FOURNIER, G.

Am. J. Respir. Crit. Care Med., Volume 159, Number 4, April 1999, 1036-1042

Inhaled Fenoterol-Ipratropium Bromide in Mechanically Ventilated Patients with Chronic Obstructive Pulmonary Disease

CLAUDE GUERIN, ARNAUD CHEVRE, PIERRE DESSIRIER, THIERRY PONCET, MARIE-HELENE BECQUEMIN, PIERRE FRANÇOIS DEQUIN, CHANTAL LE GUELLEC, DIDIER JACQUES, and GERARD FOURNIER

Service de Réanimation Médicale, Centre Hospitalier Lyon-Sud, Pierre-Bénite; Service Central d'Explorations Fonctionnelles Respiratoires, Groupe Hospitalier Pitié-Salpétrière, Paris; Groupe de Recherche Epithelium Respiratoire et Inflammation et Service de Réanimation Médicale; and Laboratoire de Pharmacologie et Toxicologie cliniques, CHU Bretonneau, Tours, France

In 18 patients with chronic obstructive pulmonary disease intubated and mechanically ventilated, we prospectively randomized 200 µg fenoterol-80 µg ipratropium bromide (four puffs) from a metered-dose inhaler (MDI) versus 1.25 mg fenoterol-500 µg ipratropium bromide in 5 ml saline from a nebulizer (NEB). Respiratory mechanics were assessed before and 30 min after the end of each delivery by the rapid end-inspiratory airway occlusion technique. We did vary on single breaths the inflation flow (V) from 0.2 to 1.2 L · s-1, at constant inflation volume. The total respiratory resistance of the respiratory system (Rrs) was partitioned into airway (Rint,rs) and tissue (Delta Rrs) resistances. We found that Rrs was equivalently reduced, from 16.49 ± 1.37 to 14.85 ± 1.88 cm H2O · L-1 · s with MDI (p < 0.05) and from 18.04 ± 1.85 to 15.15 ± 1.33 cm H2O · L-1 · s with NEB (p < 0.01). Whereas the prevailing effect of MDI was to reduce Rint,rs, that of NEB was to decrease Delta Rrs. In addition, the V resistance of the respiratory system over the whole range of V was significantly affected by NEB but not by MDI.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. Tzoufi, S. D. Mentzelopoulos, C. Roussos, and A. Armaganidis
The Effects of Nebulized Salbutamol, External Positive End-Expiratory Pressure, and Their Combination on Respiratory Mechanics, Hemodynamics, and Gas Exchange in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients
Anesth. Analg., September 1, 2005; 101(3): 843 - 850.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. A. Volta, V. Alvisi, S. Petrini, S. Zardi, E. Marangoni, R. Ragazzi, M. Capuzzo, and R. Alvisi
The Effect of Volatile Anesthetics on Respiratory System Resistance in Patients with Chronic Obstructive Pulmonary Disease
Anesth. Analg., February 1, 2005; 100(2): 348 - 353.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Schonhofer and S. Sortor-Leger
Equipment needs for noninvasive mechanical ventilation
Eur. Respir. J., October 1, 2002; 20(4): 1029 - 1036.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society