help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SILKOFF, P. E.
Right arrow Articles by CHAPMAN, K. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SILKOFF, P. E.
Right arrow Articles by CHAPMAN, K. R.

Am. J. Respir. Crit. Care Med., Volume 159, Number 3, March 1999, 940-944

Exhaled Nitric Oxide after beta 2-agonist Inhalation and Spirometry in Asthma

PHILIP E. SILKOFF, SUGURU WAKITA, JOSE CHATKIN, KHALIL ANSARIN, CARLOS GUTIERREZ, MARLOVA CARAMORI, PATRICIA MCCLEAN, ARTHUR S. SLUTSKY, NOE ZAMEL, and KENNETH R. CHAPMAN

Division of Respiratory Medicine, Faculty of Medicine, University of Toronto, Canada; The National Jewish Medical and Research Center, Denver, Colorado; and The Catholic University of Rio Grande do Sul, Porto Alegre, Brazil

Exhaled nitric oxide (ENO) is used increasingly as a surrogate marker of airway inflammation in research protocols that may incorporate standard efficacy measures, such as spirometry before and after bronchodilator, which could affect ENO measurements. In seven healthy volunteers and 11 mild asthmatic subjects, we measured ENO before and serially for 1 h after spirometry. On two additional days in the subjects with asthma, we reexamined the effect of spirometry as before, followed by the serial measurement of ENO for 1 h after two puffs of salbutamol (100 µg/puff) by metered-dose inhaler or matching placebo. As early as 1 min after spirometry, ENO fell by 13% and 10% in the normal and asthmatic subjects, respectively. In both groups, ENO returned to baseline over 1 h. In the asthmatic subjects, salbutamol caused a significant mean increase of the order of 10 parts per billion in ENO (p < 0.001) for 1 h as compared with placebo inhaler. We conclude that spirometry and beta 2-agonist may perturb ENO values and recommend that studies control for these factors.




This article has been cited by other articles:


Home page
 ChestHome page
K. G. Lim and C. Mottram
The Use of Fraction of Exhaled Nitric Oxide in Pulmonary Practice
Chest, May 1, 2008; 133(5): 1232 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Verbanck, Y. Kerckx, D. Schuermans, W. Vincken, M. Paiva, and A. Van Muylem
Effect of airways constriction on exhaled nitric oxide
J Appl Physiol, April 1, 2008; 104(4): 925 - 930.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. B. Bucca, L. Brussino, A. Battisti, R. Mutani, G. Rolla, L. Mangiardi, and A. Cicolin
Diuretics in Obstructive Sleep Apnea With Diastolic Heart Failure
Chest, August 1, 2007; 132(2): 440 - 446.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H.-W. Shin, D. A. Shelley, E. M. Henderson, A. Fitzpatrick, B. Gaston, and S. C. George
Airway nitric oxide release is reduced after PBS inhalation in asthma
J Appl Physiol, March 1, 2007; 102(3): 1028 - 1033.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H.-W. Shin, C. D. Schwindt, A. S. Aledia, C. M. Rose-Gottron, J. K. Larson, R. L. Newcomb, D. M. Cooper, and S. C. George
Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1741 - R1748.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. H. A. Tee and K. P. Hui
Clips, Spirometry, and Submaximal Inhalation for Exhaled Nitric Oxide
Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 931 - 931.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Silkoff
Clips, Spirometry, and Submaximal Inhalation for Exhaled Nitric Oxide
Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 931 - 932.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005
Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 912 - 930.
[Full Text] [PDF]

Home page
 ChestHome page
A. K. H. Tee and K. P. Hui
Effect of Spirometric Maneuver, Nasal Clip, and Submaximal Inspiratory Effort on Measurement of Exhaled Nitric Oxide Levels in Asthmatic Patients
Chest, January 1, 2005; 127(1): 131 - 134.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H.-W. Shin, P. Condorelli, C. M. Rose-Gottron, D. M. Cooper, and S. C. George
Probing the impact of axial diffusion on nitric oxide exchange dynamics with heliox
J Appl Physiol, September 1, 2004; 97(3): 874 - 882.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
F L M Ricciardolo, M C Timmers, J K Sont, G Folkerts, and P J Sterk
Effect of bradykinin on allergen induced increase in exhaled nitric oxide in asthma
Thorax, October 1, 2003; 58(10): 840 - 845.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Beier, K.M. Beeh, O. Kornmann, and R. Buhl
Sputum induction leads to a decrease of exhaled nitric oxide unrelated to airflow
Eur. Respir. J., August 1, 2003; 22(2): 354 - 357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. S. van's Gravesande, M. E. Wechsler, H. Grasemann, E. S. Silverman, L. Le, L. J. Palmer, and J. M. Drazen
Association of a Missense Mutation in the NOS3 Gene with Exhaled Nitric Oxide Levels
Am. J. Respir. Crit. Care Med., July 15, 2003; 168(2): 228 - 231.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. B. Khatri, J. Hammel, M. S. Kavuru, S. C. Erzurum, and R. A. Dweik
Temporal association of nitric oxide levels and airflow in asthma after whole lung allergen challenge
J Appl Physiol, July 1, 2003; 95(1): 436 - 440.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
E Baraldi, L Ghiro, V Piovan, S Carraro, F Zacchello, and S Zanconato
Safety and success of exhaled breath condensate collection in asthma
Arch. Dis. Child., April 1, 2003; 88(4): 358 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
Members of the Task Force:, E. Baraldi, J.C. de Jongste, B. Gaston, K. Alving, P.J. Barnes, H. Bisgaard, A. Bush, C. Gaultier, H. Grasemann, et al.
Measurement of exhaled nitric oxide in children, 2001: E. Baraldi and J.C. de Jongste on behalf of the Task Force
Eur. Respir. J., July 1, 2002; 20(1): 223 - 237.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Deykin, A. F. Massaro, J. M. Drazen, and E. Israel
Exhaled Nitric Oxide as a Diagnostic Test for Asthma: Online versus Offline Techniques and Effect of Flow Rate
Am. J. Respir. Crit. Care Med., June 15, 2002; 165(12): 1597 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
C Bruce, D H Yates, and P S Thomas
Caffeine decreases exhaled nitric oxide
Thorax, April 1, 2002; 57(4): 361 - 363.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H.-W. SHIN, C. M. ROSE-GOTTRON, R. S. SUFI, F. PEREZ, D. M. COOPER, A. F. WILSON, and S. C. GEORGE
Flow-independent Nitric Oxide Exchange Parameters in Cystic Fibrosis
Am. J. Respir. Crit. Care Med., February 1, 2002; 165(3): 349 - 357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. TERADA, T. FUJISAWA, K. TOGASHI, T. MIYAZAKI, H. KATSUMATA, J. ATSUTA, K. IGUCHI, H. KAMIYA, and H. TOGARI
Exhaled Nitric Oxide Decreases during Exercise-induced Bronchoconstriction in Children with Asthma
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1879 - 1884.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H.-W. Shin, C. M. Rose-Gottron, F. Perez, D. M. Cooper, A. F. Wilson, and S. C. George
Flow-independent nitric oxide exchange parameters in healthy adults
J Appl Physiol, November 1, 2001; 91(5): 2173 - 2181.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. M. FERREIRA, M. S. HAZARI, C. GUTIERREZ, N. ZAMEL, and K. R. CHAPMAN
Exhaled Nitric Oxide and Hydrogen Peroxide in Patients with Chronic Obstructive Pulmonary Disease . Effects of Inhaled Beclomethasone
Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 1012 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. A. KHARITONOV and P. J. BARNES
Exhaled Markers of Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1693 - 1722.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. ADRIE, M. MONCHI, A. TUAN DINH-XUAN, J. DALL'AVA-SANTUCCI, J.-F. DHAINAUT, and M. R. PINSKY
Exhaled and Nasal Nitric Oxide as a Marker of Pneumonia in Ventilated Patients
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1143 - 1149.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. DUPLAIN, C. SARTORI, M. LEPORI, M. EGLI, Y. ALLEMANN, P. NICOD, and U. SCHERRER
Exhaled Nitric Oxide in High-Altitude Pulmonary Edema . Role in the Regulation of Pulmonary Vascular Tone and Evidence for a Role against Inflammation
Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 221 - 224.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. DEYKIN, A. F. MASSARO, E. COULSTON, J. M. DRAZEN, and E. ISRAEL
Exhaled Nitric Oxide Following Repeated Spirometry or Repeated Plethysmography in Healthy Individuals
Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1237 - 1240.
[Abstract] [Full Text]

Home page
 ChestHome page
E. Clini, L. Bianchi, M. Vitacca, R. Porta, K. Foglio, and N. Ambrosino
Exhaled Nitric Oxide and Exercise in Stable COPD Patients
Chest, March 1, 2000; 117(3): 702 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Silkoff
Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children---1999 . THIS OFFICIAL STATEMENT OF THE AMERICAN THORACIC SOCIETY WAS ADOPTED BY THE ATS BOARD OF DIRECTORS, JULY 1999
Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 2104 - 2117.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 1999 American Thoracic Society 		  CCM abstracts