Am. J. Respir. Crit. Care Med.,
Volume 159, Number 3, March 1999, 924-931
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275 cells/µl) to symptomatic (either chronic cough, chronic phlegm, bronchitis
episodes, dyspnea, wheeze, or asthma) and asymptomatic bronchial hyperresponsiveness (BHR)
were studied cross-sectionally in 620 adult subjects who participated in the Vlagtwedde-Vlaardingen Study of 1989 and 1990. Eosinophilia (OR = 2.06, 95% CI = 1.28 to 3.31) and skin test positivity
(OR = 1.66, 95% CI = 1.02 to 2.71) were both significantly associated with BHR independent of age,
sex, smoking, and urban area of residence. High serum total IgE levels were not associated with BHR
(OR = 1.29, 95% CI = 0.81 to 2.03). Separate analyses for symptomatic and asymptomatic subjects
showed that the higher risk of BHR with skin test positivity applied only to symptomatic subjects
(OR = 5.78, 95% CI = 1.63 to 20.51), independent of eosinophilia and high serum total IgE levels.
The higher risk of BHR with eosinophilia was not different between symptomatic and asymptomatic
subjects, and independent of skin test positivity and high serum total IgE levels. The results of this
study show that, in the general adult population, eosinophilia is associated with BHR both in symptomatic and asymptomatic persons, whereas skin test positivity is associated with BHR only in symptomatic subjects.
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  A H Morice, L McGarvey, I Pavord, and on behalf of the British Thoracic Society Cough Gu Recommendations for the management of cough in adults Thorax, September 1, 2006; 61(suppl_1): i1 - i24. [Full Text] [PDF]
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 J. P. Siwik, C. C. Johnson, S. L. Havstad, E. L. Peterson, D. R. Ownby, and E. M. Zoratti Airway Hyperresponsiveness to Methacholine at Age 6 to 8 Years in Nonasthmatic Patients Is Not Related to Increased Health-Care Utilization for Asthma in the Ensuing 5 Years: A Longitudinal Study of a Birth Cohort Chest, October 1, 2005; 128(4): 2420 - 2426. [Abstract] [Full Text] [PDF]
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 L.-P. Boulet Asymptomatic Airway Hyperresponsiveness: A Curiosity or an Opportunity to Prevent Asthma? Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 371 - 378. [Full Text] [PDF]
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R. Hauser, E. A. Eisen, L. Pothier, D. Lewis, T. Bledsoe, and D. C. Christiani Spirometric Abnormalities Associated With Chronic Bronchitis, Asthma, and Airway Hyperresponsiveness Among Boilermaker Construction Workers* Chest, June 1, 2002; 121(6): 2052 - 2060. [Full Text] [PDF]
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N. N. BAHCECILER, C. ARIKAN, T. AKKOC, and I. B. BARLAN Predictors for the Severity of Bronchial Hyperreactivity in Childhood Asthma Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1150 - 1153. [Abstract] [Full Text] [PDF]
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 J. C. Celedón, L. J. Palmer, X. Xu, B. Wang, Z. Fang, and S. T. Weiss Sensitization to Silk and Childhood Asthma in Rural China Pediatrics, May 1, 2001; 107(5): 80e - 80. [Abstract] [Full Text]
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 S. Baldacci, E. Omenaas, and M.P. Oryszczyn Allergy markers in respiratory epidemiology Eur. Respir. J., April 1, 2001; 17(4): 773 - 790. [Abstract] [Full Text] [PDF]
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L.-P. Ho, F. T. Wood, A. Robson, J. A. Innes, and A. P. Greening Atopy Influences Exhaled Nitric Oxide Levels in Adult Asthmatics Chest, November 1, 2000; 118(5): 1327 - 1331. [Abstract] [Full Text] [PDF]
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S. Stick Paediatric origins of adult lung disease bullet 1: The contribution of airway development to paediatric and adult lung disease Thorax, July 1, 2000; 55(7): 587 - 594. [Full Text]
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